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1.
Straub C Pazdrak K Young TW Stafford SJ Wu Z Wiktorowicz JE Haag AM English RD Soman KV Kurosky A 《Proteomics. Clinical applications》2009,3(10):1151-1173
Eosinophils (EOSs) are granular leukocytes that have significant roles in many inflammatory and immunoregulatory responses, especially asthma and allergic diseases. We have undertaken a fairly comprehensive proteomic analysis of purified peripheral blood EOSs from normal human donors primarily employing 2‐DE with protein spot identification by MALDI‐MS. Protein subfractionation methods employed included IEF (Zoom® Fractionator) and subcellular fractionation using differential protein solubilization. We have identified 3141 proteins, which had Mascot expectation scores of 10?3 or less. Of these 426 were unique and non‐redundant of which 231 were novel proteins not previously reported to occur in EOSs. Ingenuity Pathway Analysis showed that some 70% of the non‐redundant proteins could be subdivided into categories that are clearly related to currently known EOS biological activities. Cytoskeletal and associated proteins predominated among the proteins identified. Extensive protein posttranslational modifications were evident, many of which have not been previously reported that reflected the dynamic character of the EOS. This data set of eosinophilic proteins will prove valuable in comparative studies of disease versus normal states and for studies of gender differences and polymorphic variation among individuals. 相似文献
2.
Kamenan Koffi A. Jagadeesh Anooja Kre N’guessan Raymond Assanvo Edja Florentin Soman Suraj Unni K. N. Narayanan 《Journal of Materials Science: Materials in Electronics》2021,32(11):14207-14216
Journal of Materials Science: Materials in Electronics - We successfully fabricated dye sensitized solar cells (DSSCs) employing a quasi-solid state electrolyte based on pristine insulator natural... 相似文献
3.
We present an empirical analysis to show that combination of short term load forecasts leads to better accuracy. We also discuss other aspects of combination, i.e., distribution of weights, effect of variation in the historical window and distribution of forecast errors. The distribution of forecast errors is analyzed in order to get a robust forecast. We define a robust forecaster as one which has consistency in forecast accuracy, lesser shocks (outliers) and lower standard deviation in the distribution of forecast errors. We propose a composite ranking (CRank) scheme based on a composite score which considers three performance measures—standard deviation, kurtosis of distribution of forecast errors and accuracy of forecasts. The CRank helps in identification of a robust forecasts given a choice of individual and combined forecaster. The empirical analysis has been done with the real life data sets of two distribution companies in India. 相似文献
4.
Wande Zhang Pranav Soman Kyle Meggs Xin Qu Shaochen Chen 《Advanced functional materials》2013,23(25):3226-3232
Cells sense and respond to mechanical forces, regardless of whether the source is from a normal tissue matrix, an adjacent cell or a synthetic substrate. In recent years, cell response to surface rigidity has been extensively studied by modulating the elastic modulus of poly(ethylene glycol) (PEG)‐based hydrogels. In the context of biomaterials, Poisson's ratio, another fundamental material property parameter has not been explored, primarily because of challenges involved in tuning the Poisson's ratio in biological scaffolds. Two‐photon polymerization is used to fabricate suspended web structures that exhibit positive and negative Poisson's ratio (NPR), based on analytical models. NPR webs demonstrate biaxial expansion/compression behavior, as one or multiple cells apply local forces and move the structures. Unusual cell division on NPR structures is also demonstrated. This methodology can be used to tune the Poisson's ratio of several photocurable biomaterials and could have potential implications in the field of mechanobiology. 相似文献
5.
Quantum chemical studies have gained paramount importance in screening of thermodynamically feasible chemical processes. The current investigation attempts to select an appropriate process for the synthesis of 1,3,5-triamino-2,4,6-trinitro benzene (TATB), a reasonably powerful insensitive high explosive (IHE) through density functional theory (DFT) calculations. Although, 1,3,5-trichlorobenzene (TCB) and 1,3,5-trihydroxybenzene (THB) routes for synthesis of TATB have been well established, this article demonstrates the predictive capability of thermochemical computations for the identification of a viable process. Thermochemical parameters of reaction species have been obtained from DFT B3LYP/6-31G? calculations and feasibility of the process has been worked out on the basis of free energies of reactions and equilibrium constant as derived from standard enthalpy and entropy of the reaction species. The detailed computational studies have revealed that the THB route is thermodynamically feasible and the same has been supported experimentally. 相似文献
6.
V.K. Pandey M. Parmeswaran S.D. Soman H.J. Dacosta 《The Science of the total environment》1982,25(3):277-285
In a grave illness the homeostasis of some elements may be upset either by the disease process per se, or by the therapy adopted. Patients with pyogenic, viral and tubercular meningo-encephalitis were targets of interest. 108 subjects' serum and cerebrospinal fluid (CSF) compartments were assayed for magnesium, calcium, zinc and copper, by atomic absorption spectrometry. Results showed that the serum pool was more intensely altered than the CSF pool in the case of magnesium and calcium but the reverse occurred for zinc and copper. No organism-dependent change was noted, but comatosed patients were the worst effected. These findings are discussed with respect to the relative brain and CSF content of each element and the patho-physiology which could alter the compartments studied. 相似文献
7.
S Rao P Parikh CS Soman VR Pai TK Saikia R Gopal SH Advani 《Canadian Metallurgical Quarterly》1993,41(11):720-721
Primary orbital lymphomas are rare. We report nine such cases (4 with DWDL, 3 with DPDL, 1 with DHL and 1 unclassifiable lymphoma). All patients achieved clinical complete remission (CR). Of those who completed treatment more than a year ago, three continue to be in CR at 17, 24 & 25 months and two are lost to follow up. 相似文献
8.
Ganeshkumar M Ravi Vinayakumar Sowmya V Gopalakrishnan E. A Soman K. P Chakraborty Chinmay 《Multimedia Tools and Applications》2022,81(25):36257-36273
Multimedia Tools and Applications - Intracranial Haemorrhage (ICH) occurring due to any injury to the brain is a fatal condition and its timely diagnosis is critically important. In this work, we... 相似文献
9.
Kamenan Koffi A. Jagadeesh Anooja Kre N’guessan Raymond Assanvo Edja Florentin Soman Suraj Unni K. N. Narayanan 《Journal of Materials Science: Materials in Electronics》2021,32(11):14217-14217
Journal of Materials Science: Materials in Electronics - A correction to this paper has been published: https://doi.org/10.1007/s10854-021-06180-2 相似文献
10.
This paper provides an alternative framework for color-to-grayscale image conversion by exploiting the chrominance information present in the color image using singular value decomposition (SVD). In the proposed technique of color-to-grayscale image conversion, a weight matrix corresponds to the chrominance components is derived by reconstructing the chrominance data matrix (planes a* and b*) from the eigenvalues and eigenvectors computed using SVD. The final grayscale converted image is obtained by adding the weighted chrominance data to the luminous intensity which is kept intact for the CIEL*a*b* color space of the given color image. The effectiveness of the proposed grayscale conversion is confirmed by the comparative analysis performed on the color-to-gray benchmark dataset across 10 existing algorithms based on the standard objective measures, namely normalized cross-correlation, color contrast preservation ratio, color content fidelity ratio, E score and subjective evaluation. 相似文献