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1.
Across 2 experiments, a new experimental procedure was used to investigate attentional capture by animal fear-relevant stimuli. In Experiment 1 (N = 34), unselected participants were slower to detect a neutral target animal in the presence of a spider than a cockroach distractor and in the presence of a snake than a large lizard distractor. This result confirms that phylogenetically fear-relevant animals capture attention specifically and to a larger extent than do non-fear-relevant animals. In Experiment 2 (N = 86), detection of a neutral target animal was slowed more in the presence of a feared fear-relevant distractor (e.g., a snake for snake-fearful participants) than in presence of a not-feared fear-relevant distractor (e.g., a spider for snake-fearful participants). These results indicate preferential attentional capture that is specific to phylogenetically fear-relevant stimuli and is selectively enhanced in individuals who fear these animals. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
2.
Reviews the book, Basic Processes in Reading Visual Word Recognition by Derek Besner and Glyn W. Humphreys (see record 1990-99017-000). While there has been an increase in the amount of work on many different aspects of reading, as Besner and Humphreys point out in the overview to their book, the vast majority of the research on the topic of reading in the past twenty years has been concerned with the processes involved in word recognition. For this reason, Besner and Humphreys have attempted to bring together studies on topics which are both relevant to current debates in the field of word recognition, and which are likely to be important for future developments in the field. They have compiled an edited volume consisting of their overview and eight additional chapters. The editors have attempted to span the continuum of processes involved in word recognition and thus have included chapters which cover topics ranging from the visual analysis of words, to those on the influence of semantic factors on word recognition. The authors of these chapters comprise an impressive list of researchers in the field of word recognition, with the majority of chapters being authored by leading researchers on the topic. Given the stature of the authors and the range of topics covered, in theory this volume should provide a very thorough overview of current theory and research on reading. There is no question that each of the chapters is interesting and important in its own right. However, in practice the volume as a whole fell somewhat short of my expectations. The different tacts taken by different authors has resulted in a very uneven coverage of the current debates in the field. Notwithstanding these criticisms, I am sure that the majority of researchers in this field will consider this volume to be an important contribution. The book would provide a very useful addition to graduate courses in cognitive sciences and as a supplemental text for an undergraduate course on the psychology of reading. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
3.
The effects of lipid peroxidation and the antioxidant vitamin E contained in LDL isolated from control plasma (LDL--) and from plasma preincubated with 0.5 mmol/ml alpha-tocopherol (LDL+) on the proliferation of estrogen-receptor positive (ER+ : ZR-75, T-47-D, MCF-7) and negative (ER--: HBL-100, MDA-MB-231) human breast cancer cells were studied. Human skin fibroblasts served as controls. Incubation of plasma with 0.5 mmol/ml alpha-tocopherol resulted in a 3-fold increase of its content and a significant reduction in lipid hydroperoxides and conjugated dienes in LDL. Incubation of fibroblasts or ER+ tumor cells with LDL- or LDL+ had an effect on neither cell proliferation nor on the cellular levels of peroxidation products as compared to control incubations in the absence of LDL. In ER- cells, however, LDL+ stimulated the proliferation, whereas LDL- yielded a cytotoxic effect. Moreover, LDL- supplementation resulted in an increase in the content of hydroperoxides and conjugated dienes. LDL+ supplemented cells exhibited hydroperoxide levels in these tumor cells comparable to the basal levels measured in the absence of LDL. Our data suggested that peroxidation products in LDL are cytotoxic to estrogen-receptor negative breast tumor cells and vitamin E counteracts this effect. 相似文献
4.
RE Sacco JS Haynes JA Harp WR Waters MJ Wannemuehler 《Canadian Metallurgical Quarterly》1998,153(6):1717-1722
Flora-bearing mice with targeted disruption of T cell receptor (TCR)-alpha or -beta genes spontaneously develop intestinal inflammation with features similar to ulcerative colitis in humans. TCR-alpha-deficient mice maintained germfree or colonized with a limited number of intestinal bacteria failed to develop inflammatory bowel disease (IBD)-like lesions. Evidently, inflammation in these mice does not develop spontaneously or result from a generalized antigenic stimulation, but rather requires induction by a heretofore unidentified specific stimulus. We describe the development of IBD-like lesions in germfree TCR-alpha-deficient mice monoassociated with the protozoan Cryptosporidium parvum. Lesions were seen in distal ileum, cecum, and colon and were most severe in the cecum. A prominent leukocytic infiltrate within the lamina propria was a common characteristic of the lesions observed in the C. parvum-infected germfree TCR-alpha-deficient mice. The leukocytic infiltrate was composed of aggregates of B220+ cells, the majority of which expressed surface IgD (ie, conventional B lymphocytes). It has been proposed that antigenic stimulation by a microorganism(s) is needed to initiate intestinal inflammation in TCR-alpha-deficient mice. Our results indicate that a single microbial species, C. parvum, is capable of triggering the development of IBD-like lesions in germfree TCR-alpha-deficient mice. 相似文献
5.
6.
We report two patients where the finding of isolated fetal hydrocephalus led to the detection of severe fetal thrombocytopenia, using fetal blood sampling. Serological investigation led to the diagnosis of fetomaternal alloimmune thrombocytopenia (FMAIT) due to anti-HPA-1a. Both women had had previous unsuccessful pregnancies probably due to FMAIT; one had had four miscarriages at 17-18 weeks' gestation. The other had had one previous pregnancy complicated by severe fetal anaemia, and eventually hydrocephalus developed and the fetus died without the diagnosis of FMAIT being considered. Subsequent pregnancies in the two women were also affected by FMAIT, but prenatal treatment, predominantly with serial fetal platelet transfusions, resulted in a successful outcome in both cases. These observations suggest that FMAIT should be suspected if there is isolated fetal hydrocephalus, unexplained fetal anaemia, or recurrent miscarriages. The accurate diagnosis of FMAIT is important because recent advances in prenatal management can improve the outcome of subsequently affected pregnancies. 相似文献
7.
Hobbie KA Peterson ES Barton ML Waters KM Anderson KA 《Journal of laboratory automation》2012,17(4):275-283
Large collaborative centers are a common model for accomplishing integrated environmental health research. These centers often include various types of scientific domains (e.g., chemistry, biology, bioinformatics) that are integrated to solve some of the nation's key economic or public health concerns. The Superfund Research Center (SRP) at Oregon State University (OSU) is one such center established in 2008 to study the emerging health risks of polycyclic aromatic hydrocarbons while using new technologies both in the field and laboratory. With outside collaboration at remote institutions, success for the center as a whole depends on the ability to effectively integrate data across all research projects and support cores. Therefore, the OSU SRP center developed a system that integrates environmental monitoring data with analytical chemistry data and downstream bioinformatics and statistics to enable complete "source-to-outcome" data modeling and information management. This article describes the development of this integrated information management system that includes commercial software for operational laboratory management and sample management in addition to open-source custom-built software for bioinformatics and experimental data management. 相似文献
8.
Arun Garg Thomas Waters Jay Kapellusch Waldemar Karwowski 《International Journal of Industrial Ergonomics》2014
The objective of this paper was to perform a comprehensive review of psychophysically determined maximum acceptable pushing and pulling forces. Factors affecting pushing and pulling forces are identified and discussed. Recent studies show a significant decrease (compared to previous studies) in maximum acceptable forces for males but not for females when pushing and pulling on a treadmill. A comparison of pushing and pulling forces measured using a high inertia cart with those measured on a treadmill shows that the pushing and pulling forces using high inertia cart are higher for males but are about the same for females. It is concluded that the recommendations of Snook and Ciriello (1991) for pushing and pulling forces are still valid and provide reasonable recommendations for ergonomics practitioners. Regression equations as a function of handle height, frequency of exertion and pushing/pulling distance are provided to estimate maximum initial and sustained forces for pushing and pulling acceptable to 75% male and female workers. 相似文献
9.
Literature reviews examining the relationship between heavy equipment vehicle (HEV) operation and the development of musculoskeletal disorders have generally been qualitative in nature and have not employed an evidence-based assessment procedure. This research determines the extent to which whole-body vibration/shock and working postures are associated with lower back and neck disorders among HEV operators, while accounting for individual (i.e. age, gender, prior history of back or neck disorders) and occupational (i.e. material handling, climatic conditions, psychosocial factors) confounders. Published articles were obtained from a search of electronic databases and from bibliographies in the identified articles. A critical appraisal of these articles was conducted using an epidemiological appraisal instrument (Genaidy et al. 2007). The meta-analysis was conducted using statistical techniques employing fixed-effect and random-effect models. Eighteen articles reporting observational studies satisfied the inclusion criteria adopted for this research. The methodological qualities of the published studies ranged from marginal to average. The meta-relative risk was found to be 2.21, indicating that operators exposed to driving HEVs are at more than twice the risk of developing lower back pain in comparison to those not exposed to driving HEVs. Therefore, it seems possible that there is a causal relationship between working as a HEV operator and development of lower back disorders. Prospective cohort studies are urgently needed to confirm the outcomes of this evidence-based methodology (based in part on the meta-analysis) and the biological plausibility should be further explored. The reported findings point to a need for improved ergonomic design of HEVs. 相似文献
10.