全文获取类型
收费全文 | 769篇 |
免费 | 26篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 62篇 |
综合类 | 1篇 |
化学工业 | 175篇 |
金属工艺 | 18篇 |
机械仪表 | 21篇 |
建筑科学 | 16篇 |
能源动力 | 36篇 |
轻工业 | 65篇 |
石油天然气 | 11篇 |
无线电 | 66篇 |
一般工业技术 | 115篇 |
冶金工业 | 103篇 |
原子能技术 | 35篇 |
自动化技术 | 72篇 |
出版年
2023年 | 6篇 |
2022年 | 16篇 |
2021年 | 27篇 |
2020年 | 12篇 |
2019年 | 16篇 |
2018年 | 19篇 |
2017年 | 16篇 |
2016年 | 24篇 |
2015年 | 18篇 |
2014年 | 18篇 |
2013年 | 43篇 |
2012年 | 36篇 |
2011年 | 47篇 |
2010年 | 29篇 |
2009年 | 37篇 |
2008年 | 31篇 |
2007年 | 38篇 |
2006年 | 17篇 |
2005年 | 24篇 |
2004年 | 27篇 |
2003年 | 17篇 |
2002年 | 15篇 |
2001年 | 9篇 |
2000年 | 12篇 |
1999年 | 14篇 |
1998年 | 54篇 |
1997年 | 31篇 |
1996年 | 24篇 |
1995年 | 10篇 |
1994年 | 11篇 |
1993年 | 14篇 |
1992年 | 4篇 |
1991年 | 2篇 |
1990年 | 4篇 |
1989年 | 7篇 |
1988年 | 2篇 |
1987年 | 4篇 |
1986年 | 5篇 |
1985年 | 6篇 |
1984年 | 7篇 |
1983年 | 6篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1980年 | 6篇 |
1979年 | 8篇 |
1977年 | 7篇 |
1976年 | 2篇 |
1973年 | 4篇 |
1970年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有796条查询结果,搜索用时 15 毫秒
1.
Mie Kurosawa Yosuke Shikama Masae Furukawa Rieko Arakaki Naozumi Ishimaru Kenji Matsushita 《International journal of molecular sciences》2021,22(5)
Immunosenescence is characterized by age-associated changes in immunological functions. Although age- and autoimmune-related sialadenitis cause dry mouth (xerostomia), the roles of immunosenescence and cellular senescence in the pathogenesis of sialadenitis remain unknown. We demonstrated that acquired immune cells rather than innate immune cells infiltrated the salivary glands (SG) of aged mice. An analysis of isolated epithelial cells from SG revealed that the expression levels of the chemokine CXCL13 were elevated in aged mice. Senescence-associated T cells (SA-Ts), which secrete large amounts of atypical pro-inflammatory cytokines, are involved in the pathogenesis of metabolic disorders and autoimmune diseases. The present results showed that SA-Ts and B cells, which express the CXCL13 receptor CXCR5, accumulated in the SG of aged mice, particularly females. CD4+ T cells derived from aged mice exhibited stronger in vitro migratory activity toward CXCL13 than those from young mice. In a mouse model of Sjögren’s syndrome (SS), SA-Ts also accumulated in SG, presumably via CXCL12-CXCR4 signaling. Collectively, the present results indicate that SA-Ts accumulate in SG, contribute to the pathogenesis of age- and SS-related sialadenitis by up-regulating chemokines in epithelial cells, and have potential as therapeutic targets for the treatment of xerostomia caused by these types of sialadenitis. 相似文献
2.
3.
Effects of 5-fluorouracil (5-FU) and UFT on an experimental liver metastasis model were compared at equi-effective dosage levels against subcutaneous tumor of mouse colon 26. 5-FU at the dosage level of 40 mg/kg suppressed the subcutaneous tumor growth by 70.0% and 45.0% on day 13 and day 18, respectively, and UFT at 20 mg/kg provided almost equal suppression (63.0% and 48.0%). In the liver metastasis model, 5-FU at 40 mg/kg showed more potent prevention of the formation of metastatic foci (94.9%) than did UFT (60.4%) at 20 mg/kg. 5-FU at 40 mg/kg produced a much higher peak serum level of 5-FU than did UFT at 20 mg/kg and also showed a much higher AUC (area under the curve) level in the portal blood. These results suggest that oral administration of 5-FU might be useful in prevention of liver metastasis of colorectal cancer. 相似文献
4.
N Gorlatova M Tchorzewski T Kurihara K Soda N Esaki 《Canadian Metallurgical Quarterly》1998,64(3):1029-1033
A nitroalkane-oxidizing enzyme was purified to homogeneity from Neurospora crassa. The enzyme is composed of two subunits; the molecular weight of each subunit is approximately 40,000. The enzyme catalyzes the oxidation of nitroalkanes to produce the corresponding carbonyl compounds. It acts on 2-nitropropane better than on nitroethane and 1-nitropropane, and anionic forms of nitroalkanes are much better substrates than are neutral forms. The enzyme does not act on aromatic compounds. When the enzyme reaction was conducted in an 18O2 atmosphere with the anionic form of 2-nitropropane as the substrate, acetone (with a molecular mass of 60 Da) was produced. This indicates that the oxygen atom of acetone was derived from molecular oxygen, not from water; hence, the enzyme is an oxygenase. The reaction stoichiometry was 2CH3CH(NO2)CH3 + O2-->2CH3COCH3 + 2HNO2, which is identical to that of the reaction of 2-nitropropane dioxygenase from Hansenula mrakii. The reaction of the Neurospora enzyme was inhibited by superoxide anion scavengers in the same manner as that of the Hansenula enzyme. Both of these enzymes are flavoenzymes; however, the Neurospora enzyme contains flavin mononucleotide as a prosthetic group, whereas the Hansenula enzyme contains flavin adenine dinucleotide. 相似文献
5.
The polarization properties of iodine complex layer deposited by oxidation of poly(vinyl alcohol) (PVA) containing metal iodide were investigated. Heat-resistant polarizing films with high polarization efficiency were produced by oxidizing and stretching the PVA containing metal iodide. The results indicate that i) the polarization efficiency of a polarizing film prepared by oxidation of a PVA film containing 1 mmol or more of potassium iodide (KI)/g PVA at 0°C for 120 s in a 10 wt.-% aqueous solution of H2O2 and a degree of stretching of 400% is high, ii) the heat resistance of the polarizing film in this experiment is higher than that of a filter prepared from a commercial PVA film. 相似文献
6.
7.
Keishi Sakamoto Atsushi Kasugai Masaki Tsuneoka Koji Takahashi Yukiharu Ikeda Tsuyoshi Imai Takashi Nagashima Mitsuru Ohta Tsuyoshi Kariya Kenichi Hayashi Yoshika Mitsunaka Yosuke Hirata Yasuyuki Itoh Yukio Okazaki 《Journal of Infrared, Millimeter and Terahertz Waves》1997,18(9):1637-1654
A development of 170GHz/500kW level gyrotron was carried out as R&D work of ITER. The oscillation mode is TE31,8. In a short pulse experiment, the maximum power of 750kW was achieved at 85kV/40A. The efficiency was 22%. In the depressed collector operation, 500kW/36%/50ms was obtained. The maximum efficiency of 40% was obtained at PRF=470kW whereas the power decrease by the electron trapping was observed. Pulse extension was done up to 10s at PRF=170kW with the depressed collector operation. The power was limited by the temperature increase of the output window. 相似文献
8.
Shuzo Ueda Ryoichi Kurihara Noriyuki Miyazaki Toshikuni Isozaki 《International Journal of Pressure Vessels and Piping》1985,18(3):161-176
The purpose of pipe rupture studies in JAERI is to perform model tests on pipe whip, restraint behavior, jet impingement and jet thrust force, and to establish a computational method for analyzing these phenomena. This report presents the analytical results of 4-inch pipe whip tests under BWR LOCA conditions.Dynamic response analyses were performed using the general-purpose finite element program ADINA. The test pipe was modelled by straight beam elements and the four restraints were modelled by a single truss element. The analytical results were compared with the experimental results. Impact time and maximum total restraint force showed good agreement with experimental results. On the other hand, pipe strain and pipe deflection could not be predicted so well. The reason for this is that the sliding of the restraint during the pipe whip movement cannot be considered in the analyses. 相似文献
9.
10.
This series of articles provides, from an international perspective, an analysis of the future of the automotive industry and aluminum’s role in automobile weight reduction. Part I briefly described technological, environmental, and societal issues that are mandating vehicular weight reduction for, among other reasons, purposes of fuel economy. Part II described the status of the weight-reduction technologies that are currently available and projects how they may evolve in the coming years. Part III, the final installment, examines some of the specific strengths and weaknesses of aluminum alloys with regard to their long-term attractiveness to automakers. 相似文献