Anti-hypertensive effects of rosiglitazone on renovascular hypertensive rats: role of oxidative stress and lipid metabolism

This study investigated the anti-hypertensive mechanism of rosiglitazone in renovascular hypertensive rats, and examined its relationship to oxidative stress and lipid metabolism. The renovascular hypertension was induced by stenosis of the left renal artery. Four groups of rats were selected: control, induced untreated, rosiglitazone (20.mg/kg) and captopril (10.mg/kg). After 14.d of administration, compared with induced untreated group, rosiglitazone group reduced the renovascular hypertensive rats' systolic blood pressure and diastolic blood pressure, and decreased total cholesterol (TCH), triglyceride (TG), angiotensin II (Ang II) and angiotensin receptor (AT₁) levels(P<0.05). Meanwhile, rosiglitazone remarkably decreased the levels of malondialdehyde (MDA) and hydrogen peroxide (H₂O₂) while improved the levels of supperoxide dismutase (SOD) and reduced glutathione (GSH). These results suggested that rosiglitazone could effectively decreased the blood pressure in renovascular hypertensive rats, and this might be performed by regulating the activity of angiotensin and the lipid metabolism and improving the oxidative stress.     

防火涂料的研究进展

防火涂料是近年来关注度较高、发展迅猛的特种功能涂料,被广泛应用在城市高楼、隧道和古建筑的保护等众多领域。从防火涂料的结构设计、性能改进以及标准化更新等角度出发,综述了钢结构防火涂料、饰面型防火涂料和隧道防火涂料近年来国内外的研究进展。简述了防火涂料的未来发展趋势,并对新一轮的技术革新提出构想。