纳米技术在中药开发中的应用

本文综述了纳米科技与中药制剂相结合的发展，阐述了纳米中药的概念、特性，介绍了纳米中药的制备技术，另外探讨了收集纳米粒子的方法，最后，着重展望了纳米技术在中药制剂中广泛的应用前景。     

Fabrication of nano Rhizama Chuanxiong particles and determination of tetramethylpyrazine

Rhizama Chuanxiong is a kind of traditional medicinal herb used to promote blood circulation and eliminate wind to relieve pain. In this work, nano Rhizoma Chuanxiong particles were successfully prepared by high speed centrifugal sheering （HSCS） pulverizer. The influence of processing parameters on the size ofRhizama Chuanxiong particles and the different properties between nano Rhizoma Chuanxiong particles and original fine powder were systematically studied by ZetaPALS light scattering granulometric analyzer and optical microscope. The content of effective ingredient tetramethylpyrazine （TMP） was determined by high-performance liquid chromatography （HPLC）. The results illustrate that general Rhizama Chuanxiong powder can be ultrafinely ground to nanometer within 50 min, and the cellular tissues ofRhizoma Chuanxiong are broken into pieces and dispersed stably and homogeneously after being ultrafinely ground. In addition, the active ingredients can dissolve out directly and fully, and the extraction ratio of TMP is increased 32.2% by HSCS processing.     

三七的超细粉碎研究

以中药三七为原料，水作溶剂，油酸作为表面活性剂，利用高速离心剪切式超细粉碎机对其进行湿式超细粉碎，成功制备了纳米三七液，并通过多种方式对其进行了粒度、显微组织形貌及其结构的表征，包括Zeta PALS粒度分析仪、光学显微镜、红外光谱、扫描电镜等方法。实验结果表明，利用高速离心剪切式超细粉碎可使颗粒尺寸达到50nm，且粉碎后药物的主要成分并没有破坏。