Anti-hypertensive effects of rosiglitazone on renovascular hypertensive rats: role of oxidative stress and lipid metabolism

This study investigated the anti-hypertensive mechanism of rosiglitazone in renovascular hypertensive rats, and examined its relationship to oxidative stress and lipid metabolism. The renovascular hypertension was induced by stenosis of the left renal artery. Four groups of rats were selected: control, induced untreated, rosiglitazone (20.mg/kg) and captopril (10.mg/kg). After 14.d of administration, compared with induced untreated group, rosiglitazone group reduced the renovascular hypertensive rats' systolic blood pressure and diastolic blood pressure, and decreased total cholesterol (TCH), triglyceride (TG), angiotensin II (Ang II) and angiotensin receptor (AT₁) levels(P<0.05). Meanwhile, rosiglitazone remarkably decreased the levels of malondialdehyde (MDA) and hydrogen peroxide (H₂O₂) while improved the levels of supperoxide dismutase (SOD) and reduced glutathione (GSH). These results suggested that rosiglitazone could effectively decreased the blood pressure in renovascular hypertensive rats, and this might be performed by regulating the activity of angiotensin and the lipid metabolism and improving the oxidative stress.     

Effect of juglone on immunity response and oxidative stress in mice

To research juglone's immunology regulation, several perspectives including immunology regulation, lymphocyte proliferation, and cytokines were presented.The index of thymus and spleen, total supperoxide dismutase activity (T-SOD), serum malondialdehyde (MDA), content of nitrogen oxide (NO), the anti-superoxide anion ability, the suppressing hydroxy radical ability, contents of reduced glutathione (GSH) in thymus, total antioxidationability (T-AOC) and the level of mouse lysozyme (LZM) in plasma were measured. LPS-induced B thymocytes proliferation was measured by MTT assay.In the low-immunity model group, MDA and NO levels were decreased (p<0.001). Juglone improved lysozyme (LZM), GSH contents in thymus, T-AOC, T-SOD activity, the anti-superoxide anion ability (anti- O2-) (p<0.001).In the stimulation immunity model group, MDA and NO levels (p<0.05), anti- O2- and T-SOD activity (p<0.05) were up-regulated, whereas LZM, T-AOC contents were down-regulated.juglone has a significant effect, which promotes cell regeneration and function recovery, also may alleviate oxidative damage; juglone possesses a dual regulating effect on humoral immunity in mice.