睡眠呼吸暂停综合征合并高血压与胰岛素抵抗的研究

目的观察OSAS合并高血压患者体内炎症水平和胰岛素抵抗的关系。方法用PSG检查确诊重度OSAS患者70例,其中40例合并高血压病。用全自动生化仪检测血清真胰岛素(FINS)、C肽、C反应蛋白、空腹血糖,用稳态模型(HOMA)计算IR指数和胰岛β细胞功能指数。结果OSAS合并高血压患者血清CRP、FINS、血清C肽、HOMA-IR和HOMA-islet均较单纯OSAS患者明显升高。结论OSAS患者的慢性炎症通过形成胰岛素抵抗,在OSAS合并高血压的过程中可能起重要作用。     

肺隐球菌病18例临床分析

目的探讨肺隐球菌病的临床特征,以提高对本病的认识。方法回顾性分析我院2001年1月-2008年8月经病理确诊为肺隐球菌病住院患者临床资料。结果本组肺隐球菌病以中青年男性为主,既往均无基础疾患。主要临床症状有咳嗽、咳痰、发热,病变影像学以肿块结节型为主,经CT引导下经皮肺穿刺活检证实7例,手术证实11例,病理诊断前误诊率达100%。11例经外科手术切除,其余应用抗真菌药物治疗,均取得较好疗效。结论肺隐球菌病多发生于中青年男性,临床表现无特异性,影像学改变以肿块结节型为主,误诊率高,确诊有赖于病理,对难以明确诊断者应尽早行病理检查。     

A mathematical morphological approach for region of interest coding of microscopy image compression

A novel mathematical morphological approach for region of interest(ROI) automatic determination and JPEG2000-based coding of microscopy image compression is presented.The algorithm is very fast and requires lower computing power,which is particularly suitable for some irregular region-based cell microscopy images with poor qualities.Firstly,an active threshold-based method is discussed to create a rough mask of regions of interest(cells).And then some morphological operations are designed and applied to achieve the segmentation of cells.In addition,an extra morphological operation,dilation,is applied to create the final mask with some redundancies to avoid the"edge effect"after removing false cells.Finally,ROI and region of background(ROB) are obtained and encoded individually in different compression ratio flexibly based on the JPEG2000,which can adjust the quality between ROI and ROB without coding for ROI shape.The experimental results certify the effectiveness of the proposed algorithm,and compared with JPEG2000,the proposed algorithm has better performance in both subjective quality and objective quality at the same compression ratios.