Tissue response of an osteoinductive bioceramic in bone defect rabbit model

HA/TCP and HA rods (?5 mm×10 mm) were made for implantation in New Zealand white rabbit with different condition. Sixty three rabbit were divided into three groups: group 1 (n=18), group 2 (n=27) and group 3 (n=18). In group 1, 10 mm radius was defected, and one HA/TCP rod was implanted in the muscle a distant away from the bone defect area. In group 2, also, 10 mm radius was defected, one HA rod was implanted in the muscle a distant away from the bone defect area. In group 3, two HA/TCP rods were implanted in the dorsal muscle of the rabbit with bone intact. Histological observation showed that in group 1, some new bone was found only two months after implantation (n=2), and obvious immature woven bone could be observed in these bioceramics from the 3^rd month on. However, in group 3, bone began to be found 6 months after implantation (n=2). In group 2, we could not find any bone tissue up to 9 month’s observation. These results suggest that, first, the bone defect model could significantly accelerate bone formation at non-osseous sites in rabbits; second,. HA/TCP bioceramics were confirmed with osteoinductive property while HA bioceramics without osteoinductive property nearly. Thus, bone defect might be a good animal model for further researches for osteoinductive bioceramics.     

碳酸钠和盐酸法提取荞麦壳中水不可溶性膳食纤维的对比研究

为提高荞麦壳利用率并且探究最佳的提取条件及增加其利用形式,本文以荞麦壳为原料,分别采用碳酸钠浸泡法和盐酸酸提法对荞麦壳中的水不可溶性膳食纤维(IDF)进行提取。结果表明,碳酸钠提取荞麦壳IDF的最佳工艺为碱解温度60 ℃,Na₂CO₃质量分数为10%,碱解时间40 min,料液比为1:13 g/mL,荞麦壳IDF的得率为82.75%,膨胀力为6.87 mL/g,持水力为379.18%。HCl酸提法提取荞麦壳IDF的最佳工艺条件为pH为2,酸浸温度为60 ℃,酸提时间为100 min,料液比为1:15 g/mL。荞麦壳IDF的得率为86.00%,膨胀力5.92 mL/g,持水力为365.31%。在最佳工艺条件下,盐酸法提取的IDF得率略高于碳酸钠法,但碳酸钠法提取的IDF具有更好的膨胀力和持水力等水合性能。     

丝素蛋白纤维提取技术的研究

丝素蛋白(SF)以其优异的性能，如较好的生物相容性、生物降解性和机械性能等，被广泛应用于生物医学领域。天然的SF需要经过脱胶处理(去除蚕丝中的丝胶)方可获得，不同的脱胶方法和工艺参数会对SF结构和性能产生不同的影响，选择合理的高效脱胶工艺方法，为制备生物医用材料提供较高性能的SF。本研究从化学、物理和生物技术几方面论述了蚕丝脱胶的方法，包括碱性、酸性、高温高压(HTHP)、超声波、微波和酶处理等，阐述了SF纤维的提取技术，以期获得高纯度、表面光滑、可降解性好和机械性能优异的SF,制备出SF新型材料，为SF在生物医用材料领域的应用提供较好的前期研究基础。     

Tissue Response of an Osteoinductive Bioceramic in Bone Defect Rabbit Model

HA/TCP and HA rods (φ5 mm×10 mm) were made for implantation in New Zealand white rabbit with different condition. Sixty three rabbit were divided into three groups: group 1 (n=18), group 2 (n=27) and group 3 (n=18). In group 1, 10 mm radius was defected, and one HA/TCP rod was implanted in the muscle a distant away from the bone defect area. In group 2, also, 10 mm radius was defected, one HA rod was implanted in the muscle a distant away from the bone defect area. In group 3, two HA/TCP rods were implanted...     

空间句法视角下的古镇街巷空间形态特征研究

历史文化村镇蕴涵着中华民族悠久历史文化的精髓,是历史文化遗产保护的重要组成部分。然而在保护工作中,对历史文化村镇整体空间形态特征及其历史发展脉络缺乏全面准确的认识。文章以固新历史文化名镇为研究案例,引入空间句法理论,建立线段分析模型,利用整合度、可理解度及选择度对古镇街巷空间形态特征进行深入剖析,旨在对古镇保护发展与人居环境改善提供有益启示。     

涉县东鹿头传统村落保护规划探析

针对传统村落在保护过程中出现的问题,以涉县东鹿头村为例,从格局形态、传统风貌、历史街巷和传统建筑等方面,制定切实可行的保护措施,为我国传统村落的保护与发展提供借鉴。