Learning in multimodal training: Visual guidance can be both appealing and disadvantageous in spatial tasks

Multimodal training involving both visual and auditory information was shown to improve text comprehension and reduce cognitive load. However, it is argued that in spatial tasks visual guidance can impair training effectiveness because it encourages shallow performance strategies and little exploration. Moreover, visual aids are attractive to both trainers as well as trainees, who tend to use them despite their potential disadvantages. To examine this potential training trap, two experimental studies were conducted. In Study 1, each trainer instructed trainees on how to perform a 3-D puzzle in two conditions: vocal guidance (17 trainees), where only vocal instructions were possible, and vocal guidance with mouse pointing (17 trainees), where the trainer could also use a mouse to point out positions on the trainee's screen. The results showed that while the use of the mouse pointer reduced trainees' mental load during training, it also drastically lowered performance level on a non-supervised test. In Study 2, a real-world version of puzzle was trained. A comparison of a vocal guidance group (16 trainees) to a group trained with an additional mouse pointing and drawing option (16 trainees) showed, as well, reduced performance levels with the additional visual aids. The results suggest that the abundant use of multimodal training in Augmented Reality (AR) applications should be re-evaluated.     

Orthographic Structure Versus Morphological Structure: Principles of Lexical Organization in a Given Language.

Most models of visual word recognition in alphabetic orthographies assume that words are lexically organized according to orthographic similarity. Support for this is provided by form-priming experiments that demonstrate robust facilitation when primes and targets share similar sequences of letters. The authors examined form-orthographic priming effects in Hebrew, Arabic, and English. Hebrew and Arabic have an alphabetic writing system but a Semitic morphological structure. Hebrew morphemic units are composed of noncontiguous phonemic (and letter) sequences in a given word. Results demonstrate that form-priming effects in Hebrew or Arabic are unreliable, whereas morphological priming effects with minimal letter overlap are robust. Hebrew bilingual subjects, by contrast, showed robust form-priming effects with English material, suggesting that Semitic words are lexically organized by morphological rather than orthographic principles. The authors conclude that morphology can constrain lexical organization even in alphabetic orthographies and that visual processing of words is first determined by morphological characteristics. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Bioorthogonal Chemical Reporters for Monitoring Unsaturated Fatty‐Acylated Proteins

Dietary unsaturated fatty acids, such as oleic acid, have been shown to be covalently incorporated into a small subset of proteins, but the generality and diversity of this protein modification has not been studied. We synthesized unsaturated fatty‐acid chemical reporters and determined their protein targets in mammalian cells. The reporters can induce the formation of lipid droplets and be incorporated site‐specifically onto known fatty‐acylated proteins and label many proteins in mammalian cells. Quantitative proteomics analysis revealed that unsaturated fatty acids modify similar protein targets to saturated fatty acids, including several immunity‐associated proteins. This demonstrates that unsaturated fatty acids can directly modify many proteins to exert their unique and often beneficial physiological effects in vivo.     

Achilles’ heel strategy: identifying and leveraging a competitor’s weakest point

Significant developments in military strategy over the past century have had little impact, if any, on business strategy. This article focuses on the military paradigm shift from brute-force frontal confrontation as practised in the First World War to shrewd identification of weaknesses in the adversary’s rear. To apply this insight in the business world, we present a methodology focusing on the weakest link: the Achilles’ heel. We apply this methodology in identifying the adversary’s Achilles’ heel and attacking it. We aim to avoid attacking the competitor’s front namely its products in the marketplace through painful head-to-head attrition price and advertising wars. Instead, we propose a new attack strategy – focusing on the adversary’s weakest link. The study integrates a new military insight, specifically from an approach called operational theory, with an insight from the theory of constraints. The sophistication of the Achilles’ heel strategy makes it particularly effective for small players – David competing with large Goliaths. We present a methodology: identifying the Achilles’ heel; deciding whether or not to attack it; and tailoring an Achilles’ heel strategy. The theory is illustrated by numerous business and military applications.     

Delineation of Subsea Freshwater Extension by Marine Geoelectromagnetic Soundings (SE Mediterranean Sea)

This study presents a novel application of marine geoelectromagnetic technique, in an attempt to delineate freshwater extension of the coastal sub-aquifers beneath the SE Mediterranean Sea, along central Israel. The novel marine Ex-Bz time domain electromagnetic (TDEM) geophysical method was applied, demonstrating high sensitivity to the presence of sub-seafloor electrically resistive structures up to several kilometers offshore (shallow marine environment). The study included 19 marine measurements located offshore between Ashdod in the south to Tel-Aviv in the north, where a previous onshore study detected fresh groundwater below seawater intrusion at the coast line. The offshore measurements were conducted to distances of up to 3 km from the shoreline. It was found that the lower sub-aquifer contains fresh groundwater (resistivity >10 Ω-m) to a distance of 2.8 km offshore along the 30 km strip, and is probably constrained by lateral geo-facial changes.     

Application of a computational decision model to examine acute drug effects on human risk taking.

In 3 previous experiments, high doses of alcohol, marijuana, and alprazolam acutely increased risky decision making by adult humans in a 2-choice (risky vs. nonrisky) laboratory task. In this study, a computational modeling analysis known as the expectancy valence model (J. R. Busemeyer & J. C. Stout, 2002) was applied to individual-participant data from these studies, for the highest administered dose of all 3 drugs and corresponding placebo doses, to determine changes in decision-making processes that may be uniquely engendered by each drug. The model includes 3 parameters: responsiveness to rewards and losses (valence or motivation); the rate of updating expectancies about the value of risky alternatives (learning/memory); and the consistency with which trial-by-trial choices match expected outcomes (sensitivity). Parameter estimates revealed 3 key outcomes: Alcohol increased responsiveness to risky rewards and decreased responsiveness to risky losses (motivation) but did not alter expectancy updating (learning/memory); both marijuana and alprazolam produced increases in risk taking that were related to learning/memory but not motivation; and alcohol and marijuana (but not alprazolam) produced more random response patterns that were less consistently related to expected outcomes on the 2 choices. No significant main effects of gender or dose by gender interactions were obtained, but 2 dose by gender interactions approached significance. These outcomes underscore the utility of using a computational modeling approach to deconstruct decision-making processes and thus better understand drug effects on risky decision making in humans. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

In vivo quantitative three-dimensional localization of tumor labeled with exogenous specific fluorescence markers

We introduce a diffused optical detection system based on the administration of a fluorophore-antibody conjugate to diseased tissue. The conjugate interacts with the antigens expressed by the diseased tissue, resulting in fluorescent labeling of the antigen. By combining an optical detection system with a reconstruction algorithm developed on the basis of the random-walk model, we were able to determine the position of the fluorophore (and, thus, of the diseased cells) in the tissue. We present three-dimensional reconstructions of the location of a fluorophore (FITC-fluorescein isothiocyanate) in the tongues of mice. Measurements were performed with the fluorophore embedded at various simulated depths. The simulations were performed with agarose-based gel slabs applied to the tongue as tissuelike phantoms. Reconstructed fluorophore locations agree well with the actual values.