用含夹带剂丙酮的超临界CO2快速膨胀法制备灰黄霉素的微细颗粒

Griseofulvin (GF) is an antifungal drug whose pharmaceutical activity can be improved by reducing particle size. In this study the rapid expansion of supercritical solution (RESS) was employed to micronize GF.Carbon dioxide with cosolvent acetone was chosen as a supercritical mixed solvent. The solubility of GF in super-critical CO2 with cosolvent acetone was measured using a dynamic apparatus at pressures between 12 and 32 MPa,temperatures at 313, 323 and 333 K and cosolvent concentration at 1.5, 3.0, 4.5 and 6.0% (by mole). The effect of pre-expansion pressure, extraction temperature, spraying distance, nozzle size and concentration of cosolvent on the precipitated particles was investigated. The results show that the mean particle size of griseofulvin precipitated by RESS was less than 1.2μm. An increase in pre-expansion pressure, extraction temperature, spraying distance and concentration of cosolvent resulted in a decrease in particle size under the operating condition studied. With the decrease of nozzle diameter the particle size reduces. The crystallinity and melting point of the original material and the processed particle by RESS were tested by X-ray diffraction (XRD) and differential scanning calorimetry (DSC).No evident modification in the crystal habit was found under the experimental conditions tested. The morphology of particles precipitated was analyzed bY scanning electron microscopy (SEM).     

一种分动器调整垫片的尺寸链计算及优化

在介绍分动器的基础上,对耦合器式分动器总成中关键调整垫片的测选尺寸链计算方法进行了深入的分析,并针对目前工艺方法存在的不足进行了优化,通过优化提高了分动器的装配质量和装配效率。     

氯甲氧基丁烷的合成及应用

摘 要 本文采用正丁醇、多聚甲醛及干燥的氯化氢气体为主要原料,合成氯甲基化试剂烷基氯甲醚-氯甲氧基丁烷(CMB)。采用红外光谱(FTIR)与核磁共振谱(1H-NMR)对产物进行了表征。考察了溶剂用量,物料摩尔比,反应温度及反应时间对CMB收率的影响。采用正交试验法获得的最佳反应条件为溶剂1,2-二氯乙烷50 mL,n(正丁醇)：n(CH2O)=3:2.00, 温度为0-5 ℃, 反应时间为7 h。在此条件下,氯甲氧基丁烷的收率可达92%。用制备的氯甲氧基丁烷氯甲基化交联度为10%的白球,用佛尔哈德滴定法测氯含量,测得制得氯球中氯含量为13%。     

二氧化氯对含酚和含硫化物工业废水处理的研究

利用稳定性二氧化氯分别对含酚和含硫化物工业废水的处理进行了研究，考察了稳定性二氧化氯的加入量，二氧化氯的活化时间，废水pH值，处理温度和处理时间等因素对废水处理效果的影响。实验得到了各种废水的适宜处理条件。     

5-(1-苯乙基)-8-氨基喹啉的合成工艺

以N-(喹啉-8-基)新戊酰胺和DL-1-苯乙醇为原料,酸酐为添加剂,无水三氯化铁为催化剂,1,2-二氯乙烷为溶剂制备标题化合物,产品结构经1HNMR和13CNMR表征。通过单因素实验,考察添加剂的种类、反应时间、反应温度、催化剂用量、添加剂用量对反应收率的影响,最终确定合成标题化合物的最佳条件为:n(N-(喹啉-8-基)新戊酰胺)∶n(DL-1-苯乙醇)∶n(添加剂)=1∶3∶3,催化剂为20 mol%无水三氯化铁,溶剂为1,2-二氯乙烷,反应温度为140℃、反应时间为24 h,产品收率可达83%。方法原料易得、操作简单、步骤节省,为产品的工业化奠定了基础。     

3,7-二氟-10,11-二氢-二苯并[b,f]-氮杂■的合成

以4-氟-2-硝基甲苯为原料,经聚合、还原、缩合得到标题化合物,总收率20.3%.该方法步骤少、操作简便、收率较高,具有工业应用价值.     

用含夹带剂丙酮的超临界CO2快速膨胀法制备灰黄霉素的微细颗粒

Griseofulvin (GF) is an antifungal drug whose pharmaceutical activity can be improved by reducingparticle size. In this study the rapid expansion of supercritical solution (RESS) was employed to micronize GF.Carbon dioxide with cosolvent acetone was chosen as a supercritical mixed solvent. The solubility of GF in super-critical CO2 with cosolvent acetone was measured using a dynamic apparatus at pressures between 12 and 32 MPa,temperatures at 313, 323 and 333K and cosolvent concentration at 1.5, 3.0, 4.5 and 6.0% (by mole). The effect ofpre-expansion pressure, extraction temperature, spraying distance, nozzle size and concentration of cosolvent on theprecipitated particles was investigated. The results show that the mean particle size of griseofulvin precipitated byRESS was less than 1.2 μm. An increase in pre-expansion pressure, extraction temperature, spraying distance andconcentration of cosolvent resulted in a decrease in particle size under the operating condition studied. With thedecrease of nozzle diameter the particle size reduces. The crystallinity and melting point of the original material andthe processed particle by RESS were tested by X-ray diffraction (XRD) and differential scanning calorimetry (DSC).No evident modification in the crystal habit was found under the experimental conditions tested. The morphologyof particles precipitated was analyzed by scanning electron microscopy (SEM).     

气相色谱法测定仲丁基溴含量内标物的确定

采用气相色谱内标法,利用9800TFP型气相色谱仪在柱箱温度:90℃,汽化温度:260℃,检测温度:260℃,柱前压:0.05MPa,采用二阶程序升温分析,结果表明乙二醇二乙醚在保留时间、峰形状都较好,可作为分析定量分析仲丁基溴的内标物,其线性回归方程为y=-0.02936+1.11691x,相关系数为0.9995,质...     

氯甲氧基丁烷的制备及初步应用

用正丁醇、多聚甲醛及干燥的氯化氢气体为主要原料,合成氯甲基化试剂———氯甲氧基丁烷(CMB)。采用傅里叶变换红外光谱(FTIR)与核磁共振氢谱(1HNMR)对产物进行了表征。考察了溶剂用量、物料摩尔比、反应温度及反应时间对CMB收率的影响。获得的最佳反应条件为:溶剂1,2-二氯乙烷50 mL,n(正丁醇)∶n(多聚甲醛)=3∶2,温度为0～5℃,反应时间为7 h;在该条件下,氯甲氧基丁烷的收率可达92%。用制备的氯甲氧基丁烷氯甲基化交联度为10%的白球得到氯甲基化聚苯乙烯微球,并用佛尔哈德滴定法测得其中氯的质量分数为13%。     

制药工程专业教学计划与培养方案的改革

本文重点介绍郑州大学制药工程专业新修订的教学计划与培养方案的总体框架及改革思路,阐述新的教学计划与培养方案的特点,目的是增进各高校间制药工程本科专业培养方案的交流。