超临界流体抗溶剂法制备叶黄素/羟丙甲纤维素邻苯二甲酸酯纳米微胶囊

Lutein was nano-encapsuled with hydroxypropylmethyl cellulose phthalate (HPMCP) to maintain its bioactivity and to avoid thermal/light degradation. Supercritical antisolvent precipitation was applied to prepare lutein/HPMCP nano-capsule. The effects of several operating parameters on the yield, lutein loading, encapsulation efficiency, particle size and particle size distribution of the nanocapsule were investigated. The mean diameter of nanocapsules ranged from 163 nm to 219 nm under appropriate experimental conditions. The result of scanning electron microscope showed that the nanocapsules were nearly spherical. The highest yield reached 95.35% when the initial concentration of lutein was saturated. The highest lutein loading of 15.80% and encapsulation efficiency of 88.41% were obtained under the conditions of 11 MPa, 40C and CHPMCP︰Clutein 5︰l. The results may pro-mote the application of lutein in food industry.     

超临界抗溶剂法制备维生素D3脂质体前体及其表征（英文）

Vitamin D3 (VD3) proliposomes (VDP), consisted of hydrogenated phosphatidycholine (HPC) and VD3, were prepared using supercritical anti-solvent technology (SAS). The effects of operation conditions (temperature, pressure and components) on the VD3 loading in VDP were studied. At the optimum conditions of pressure of 8.0 MPa, temperature of 45 ℃, and the mass ratio of 15.0% between VD3 and HPC, the VD3 loading reached 12.89%. VD3 liposomes (VDL) were obtained by hydrating VDP and the entrapment efficiency of VD3 in VDL reached 98.5%. The morphology and structure of VDP and VDL were characterized by SEM (scanning electron micro-scope), TEM (transmission electron microscope) and XRD (X-ray diffractometer). The structure of VD3 nanoparti-cles in HPC matrix was formed. The size of VDL with an average diameter of about 1μm was determined by dynamic light scattering instrument (DLS). The results indicated that VDP can be made by SAS and VDL with high entrapment efficiency can be formed easily via the hydration of VDP.     

气溶胶溶剂萃取技术制备β-谷甾醇亚微粒

The submicroparticles of β-sitosterol were produced by using an aerosol solvent extraction system (ASES) and characterized by scanning electronic microscope (SEM), X-ray diffraction (XRD), and Fourier transform infrared (FT-IR) analysis. The effects of operational parameters including pressure, temperature, solution concentration, and ratio of flow rate (CO2/solution, r) on particle size (PS), yield, and morphology were investigated. The results showed that microparticles of β-sitosterol (less than 1000 nm size and larger than 70% yield) could be obtained at 10-15 MPa, 35-50°C, 15 mg•ml－1, 10/1(r); β-sitosterol particles were found to occur as three mophologies: flakes, rods, and spheres by varying ratio of flow rate or solution concentration. In contrast, the crystallinity of β-sitosterol decreased, whereas its molecular structure remained almost unchanged after being ASES-treated. Therefore, ASES was an effective method to produce submicroparticles of β-sitosterol.