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1.
The cyclooxygenase-2 (COX-2) is a potent enzyme that converts arachidonic acid to prostaglandins (PG), including PGE2, a key mediator of inflammation and angiogenesis. Importantly, COX-2 is activated in response to inflammatory stimuli, where it is also believed to promote the development and progression of head and neck cancers (HNC). COX-2 can mediate its protumorigenic effect through various mechanisms, such as inducing cell proliferation, inhibition of apoptosis, and suppressing the host’s immune response. Furthermore, COX-2 can induce the production of vascular endothelial growth factors, hence, promoting angiogenesis. Indeed, the ability of COX-2 inhibitors to selectively restrict the proliferation of tumor cells and mediating apoptosis provides promising therapeutic targets for cancer patients. Thus, in this comprehensive review, we summarized the reported differential expression patterns of COX-2 in different stages of head and neck carcinogenesis—from potentially premalignant lesions to invasive carcinomas. Furthermore, we examined the available meta-analysis evidence for COX-2 role in the carcinogenesis of HNC. Finally, further understanding of the biological processes of COX-2 and its role in orchestrating cell proliferation, apoptosis, and angiogenesis may give therapeutically beneficial insight to develop the management plan of HNC patients and improve their clinical outcomes. 相似文献
2.
Abdelhakim Khatab Nidhal Rezg Daoud Ait-Kadi 《Journal of Intelligent Manufacturing》2011,22(6):885-889
In this paper we consider the block replacement policy (BRP) for a system operating over a random time horizon. Under such
a policy, a system is replaced by a new one either at failure or at a given time interval. The optimality criterion is the
expected total replacements cost. Conditions under which an optimal replacement period exits are given. It is shown that BRP
over an infinite time horizon is obtained as a particular case of the present work. A numerical example is given to illustrate
the proposed replacement model. 相似文献
3.
Most of the literature on scheduling assumes that machines are always available. However, in real life industry, machines may be subject to some unavailability periods due to maintenance activities such as breakdowns (stochastic case) and preventive maintenance (deterministic case). In this paper we investigate the two-stage hybrid flow shop scheduling problem with only one machine on the first stage and m machines on the second stage to minimize the makespan. We consider that each machine is subject to at most one unavailability period. The start time and the end time of each period are known in advance (deterministic case) and only the non-resumable case is studied. First we discuss the complexity of the problem. Afterwards, we give the Branch and Bound model for this problem. Last, we calculate the worst-case performances of three heuristics: LIST algorithm, LPT algorithm and H-heuristic. 相似文献
4.
Bouazza Fahsi Abdelhakim Kaci Abdelouahed Tounsi El Abbas Adda Bedia 《Journal of Mechanical Science and Technology》2012,26(12):4073-4079
In this paper we present a new application for a four variable refined plate theory to analyse the nonlinear cylindrical bending behavior of functionally graded plates subjected to thermomechanical loadings. This recent theory is based on the assumption that the transverse displacements consist of bending and shear components in which the bending components do not contribute toward shear forces and, likewise, the shear components do not contribute toward bending moments. The theory accounts for a quadratic variation of the transverse shear strains across the thickness, and satisfies the zero traction boundary conditions on the top and bottom surfaces of the plate without using shear correction factors. The material properties are assumed to vary continuously through the thickness of the plate according to a power-law distribution of the volume fraction of the constituents. The non-linear strain-displacement relations in the von Karman sense are used to study the effect of geometric non-linearity. The solutions are achieved by minimizing the total potential energy and the results are compared to the classical and the first-order theories reported in the literature. It can be concluded that the proposed theory is accurate and simple in solving the nonlinear cylindrical bending behavior of functionally graded plates. 相似文献
5.
Abdelkader Hocine Abdelhakim Maizia Abdelhamid Ghouaoula Hocine Dehmous 《Journal of Failure Analysis and Prevention》2018,18(6):1439-1446
The diversified use of filamentary composites in harsh marine environments, recorded in recent years, has prompted researchers to focus their work on the reliability prediction. Through failure criteria, Tsai–Wu and the maximum stress, the reliability of multilayer tubular structures under mechanical loading is the subject of this paper, where Monte Carlo method estimated the failure probability. A sensitivity analysis was performed in order to identify the influence of the different parameters, such as materials’ properties, geometry, manufacturing and loading, on the reliability of the composite cylindrical structure studied. To achieve a high accuracy of the results, we have carried out 105 simulations. The results showed great influence on pressure loading, ply thickness and finally winding angle of filament composite. 相似文献
6.
7.
We propose an autoregressive conditional duration (ACD) model with periodic time-varying parameters and multiplicative error form. We name this model periodic autoregressive conditional duration (PACD). First, we study the stability properties and the moment structures of it. Second, we estimate the model parameters, using (profile and two-stage) Gamma quasi-maximum likelihood estimates (QMLEs), the asymptotic properties of which are examined under general regularity conditions. Our estimation method encompasses the exponential QMLE, as a particular case. The proposed methodology is illustrated with simulated data and two empirical applications on forecasting Bitcoin trading volume and realized volatility. We found that the PACD produces better in-sample and out-of-sample forecasts than the standard ACD. 相似文献
8.
Tabti Sabrina Benchettara Abdelkader Smaili Fatiha Benchettara Abdelhakim Berrabah Salah Eddine 《Journal of Applied Electrochemistry》2022,52(8):1207-1217
Journal of Applied Electrochemistry - The modification of an iron electrode was carried out according to the following two steps. In a first step, a cathodic reduction is performed to form a film... 相似文献
9.
10.
Mohammed Ali Almomani Mohammed Aladeemy Abdelhakim Abdelhadi Ahmad Mumani 《Computers & Industrial Engineering》2013
Short setup time is an essential element for the effective implementation of many lean pillars, i.e., JIT, and Kanban. Most of the current setup reduction methodologies are based on Shingo’s Single Minute Exchange of Dies (SMED) that suggests the conversion of internal setup operations to external operations. However, the conventional SMED approach – as proposed by Shingo – does not possess a systematic approach to accomplish this conversion. Thus, a new approach is proposed in order to aid the process engineers in implementing SMED. The proposed approach is based on the conventional SMED, but also it incorporates Multiple Criteria Decision-Making Techniques (MCDM) to the third implementation phase. The MCDM techniques used in this work are Analytical Hierarchal Process (AHP), Preference Selection Index (PSI) and Technique for Order Preference by Similarity to Ideal Solution (TOPSIS). The proposed approach provides a systematic procedure for selecting the best setup technique among the available alternatives, and takes also into consideration other factors that affect the decision-making process; including: cost, energy, facility layout, safety, life, quality and maintenance. A real example of PVC industry is used to exemplify the approach. The results demonstrate the capability of the proposed approach in setup time reduction, which in turn will improve machines’ utilization, and increase the productivity and flexibility of the whole facility. 相似文献