Cerebral microbleeds and cognitive decline in a hemodialysis patient: Case report and review of literature

Cerebral microbleeds (CMBs) are small hemosiderin deposits indicative of prior cerebral microscopic hemorrhage and previously thought to be clinically silent. Recent population‐based cross‐sectional studies and prospective longitudinal cohort studies have revealed association between CMB and cognitive dysfunction. In the general population, CMBs are associated with age, hypertension, and cerebral amyloid angiopathy. In the chronic kidney disease (CKD) population, diminished estimated glomerular filtration rate has been found to be an independent risk factor for CMB, raising the possibility that a uremic milieu may predispose to microbleeds. In the end‐stage renal disease (ESRD) population on hemodialysis, the incidence of microbleeds is significantly higher compared with a control group without history of CKD or stroke. We present an ESRD patient on chronic hemodialysis with a history of gradual cognitive decline and progressive CMBs. Through this case and literature review, we illustrate the need to develop detection and prediction models to treat this frequent development in ESRD patients.     

Parallel interval-based reasoning in medical knowledge-based system Clinaid

The paper continues a series of papers and a monograph [33], where we have described the conceptual structures as well as the basic architecture of a knowledge-based systemCunaid.     

Energy and load balancing routing protocol for IoT

Due to the limitation of node energy resources, the management of energy consumption is one of the most important problems of the internet of things (IoT). Therefore, many studies have tried to optimize and manage energy consumption by focusing on different techniques. Although each of these studies has improved and optimized energy consumption, there are many important problems, including maintaining traffic balance and energy consumption of network nodes. Therefore, a new method is necessary to maintain the load and energy balancing of network nodes. Therefore, this paper introduces energy and load balancing routing protocol for IoT (ELBRP) based on the development of the RPL routing protocol and the efficiency of data distribution technique. The ELBRP performance has three steps. In the first step, along with the process of sending DODAG information object (DIO) messages, the status of network nodes is evaluated. In the second step, the DODAG communication graph is formed according to the ELBRP. In the third step, data transmission is done according to the distribution technique with the goal of balancing traffic and energy. The simulation results using cooja simulator showed the superiority of ELBRP in improving energy consumption and successful delivery ratio, reducing delay and increasing the network lifetime compared to the similar methods.     

Differential graphical games for H∞ control of linear heterogeneous multiagent systems

Differential graphical games have been introduced in the literature to solve state synchronization problem for linear homogeneous agents. When the agents are heterogeneous, the previous notion of graphical games cannot be used anymore and a new definition is required. In this paper, we define a novel concept of differential graphical games for linear heterogeneous agents subject to external unmodeled disturbances, which contain the previously introduced graphical game for homogeneous agents as a special case. Using our new formulation, we can solve both the output regulation and H_∞ output regulation problems. Our graphical game framework yields coupled Hamilton‐Jacobi‐Bellman equations, which are, in general, impossible to solve analytically. Therefore, we propose a new actor‐critic algorithm to solve these coupled equations numerically in real time. Moreover, we find an explicit upper bound for the overall ‐gain of the output synchronization error with respect to disturbance. We demonstrate our developments by a simulation example.     

Polyampholyte acrylic latexes for tablet coating applications

Polyampholyte latexes can exist within a certain pH range as low‐viscosity aqueous dispersions, while upon a pH shift to the vicinity of the isoelectric point they undergo ionic coacervation. Three classes of coacervation latexes were synthesized and evaluated for their suitability for use in tablet coating applications. Pharmaceutical tablet coatings are commonly based on hydroxypropyl methyl cellulose, poly(vinyl alcohol), and acrylic polymers. Because of the high viscosity of their aqueous solutions, and to the consequent required low concentrations of the tablet coating polymers in the coating solutions to enable sufficiently low viscosity for effective spray application, the current commercial pharmaceutical tablet coating technology requires the removal of large amounts of water during the manufacturing process. In this work, films prepared from high‐solids, low‐viscosity coacervated acrylic latexes showed good hardness, very low tackiness, an excellent combination of optical properties, and very low water vapor permeability. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 40049.     

Effects of a titanate coupling agent on the mechanical and thermo‐physical properties of talc‐reinforced polyethylene compounds

An experimental study was carried out to investigate the effects of a titanate coupling agent on the mechanical properties, moisture absorption, and thermal conductivity of talc‐filled high‐density polyethylene (HDPE). Talc (0–35 wt %) was used as reinforcement particulate filler in an HDPE matrix and samples were prepared in a micro‐compounder and an injection molding machine. Isopropyl tri(dioctyl)phosphate titanate (0.5 wt %) was used as coupling agent. Composites with and without coupling agent were evaluated for changes in mechanical and thermo‐physical properties, morphology, and void content. Addition of the titanate coupling agent most often resulted in an increase in stiffness and tensile strength. Furthermore, both the void content and the elongation at break of composites were reduced. Results also showed that the coupling agent had no effects on the thermal conductivity, thermal diffusivity, and specific heat capacity of the composites. In addition, it was observed that the coupling agent was more effective at low concentrations of filler. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 40449.     

Optima localization by vehicle formations imitating the Nelder-Mead simplex algorithm

In this paper, we address the problem of localizing extrema points and iso-contours of ambient environmental fields (specifically, ocean bottom landscape and underwater plumes) using a networked formation of autonomous underwater vehicles. We propose the use of the Nelder-Mead extension to the basic simplex nonlinear optimization algorithm. In these robust gradient-free strategies, decisions are solely made based on field values measured by the individual vehicles, while measurements are fused and actions decided according to the algorithm. A main goal of this paper is to trigger interest in direct search methods as pertains to this type of robotic problem.     

Load Tests on Prestressed Precast Concrete and Timber Piles

This paper presents the results of six pile-load tests performed on timber and prestressed concrete piles. Five axial compressive pile-load tests and one lateral-load test are presented. Comparisons are made between the results of these tests and predictions made using available geotechnical computer software. These comparisons provide an insight into using the Brinch-Hansen method of pile-load test evaluation along with wave equation and other computer analyses to evaluate pile capacities from load test data. This paper demonstrates how wave equation analyses can be used to anticipate and mitigate excess driving stresses during the installation of prestressed concrete piles. This paper also demonstrates that the use of well-established analytical methods can adequately predict the vertical and lateral behavior of timber and prestressed concrete piles. However, the bending rigidity of concrete piles under lateral loading should be carefully selected to obtain a good prediction to the measured data.     

The full cost of high-speed rail: an engineering approach

This paper examines the full costs, defined as the sum of private and social costs, of a high-speed rail system proposed for a corridor connecting Los Angeles and San Francisco in California. The full costs include infrastructure, fleet capital and operating expenses, the time users spend on the system, and the social costs of externalities, such as noise, pollution, and accidents. Comparing these full costs to those of other competing modes contributes to the evaluation of the feasibility of high-speed rail in the corridor. The paper concludes that high-speed rail is significantly more costly than expanding existing air service, and marginally more expensive than auto travel. This suggests that high-speed rail is better positioned to serve shorter distance markets where it competes with auto travel than longer distance markets where it substitutes for air. Received: May 1996 / Accepted in revised form: December 1996