Geochemical prospection of cadmium in a high incidence area of prostate cancer, Sierra de Gata, Salamanca, Spain.

A high incidence of prostate cancer was observed in some areas of Salamanca province, Spain. After excluding the most common etiological factors as the cause, it is concluded that the only possible risk factor must be due to the presence of some environmental carcinogen. In view of the etiological relationship between Cd and the pathological state, a study was carried out on the geochemistry of this element in the area. Anomalous amounts of Cd were found in stream sediments. This anomaly does not correspond to human activity, but rather to high regional amounts of cadmium in the substrate. Thus, the contents of Cd in soils developed over substrates containing naturally-occurring anomalous amounts of cadmium and the concentration in underground waters should be considered as a risk factor in this area.     

A hybrid dynamic motion prediction method for multibody digital human models based on a motion database and motion knowledge

In this paper, we present a novel method to predict human motion, seeking to combine the advantages of both data-based and knowledge-based motion prediction methods. Our method relies on a database of captured motions for reference and introduces knowledge in the prediction in the form of a motion control law, which is followed while resembling the actually performed reference motion. The prediction is carried out by solving an optimization problem in which the following conditions are imposed to the motion: must fulfill the goals of the task; resemble the reference motion selected from the database; follow a knowledge-based dynamic motion control law; and ensure the dynamic equilibrium of the human model, considering its interactions with the environment. In this work, we apply the proposed method to a database of clutch pedal depression motions, and we present the results for three predictions. The method is validated by comparing the results of the prediction to motions actually performed in similar conditions. The predicted motions closely resemble the motions in the validation database and no significant differences have been noted either in the motion’s kinematics or in the motion’s dynamics.     

Imhotep: an approach to user and device conscious mobile applications

As the dependence on mobile devices increases, the need for supporting a wider range of users and devices becomes crucial. Elders and people with disabilities adopt new technologies reluctantly, a tendency caused by the lack of adaptation of these technologies to their needs. To address this challenge, this paper describes a framework, Imhotep, whose aim is to aid developers in the accessible application creation process, making the creation of user-centered applications easier and faster. Our framework allows to easily adapt the applications to the constraints imposed by the user capabilities (sensorial, cognitive, and physical capabilities) and device capabilities by providing a repository that will manage the compilation and deployment of applications that include a set of preprocessor directives in the source code. These directives are enhanced with concepts that are automatically adjusted to the current trends of mobile devices by using a Fuzzy Knowledge-Eliciting Reasoner. Our final goal is to increase the number of applications targeted to elders and people with disabilities providing tools that facilitate their development. The paper also describes the evaluation of both the accuracy of the fuzzy terms generated for mobile devices and the usability of the proposed platform.     

Less cyber,more café: Enhancing existing small businesses across the digital divide with ICTs

About 10% of the world has access to information and communication technologies (ICTs). Telecenters and cyber cafés are one prevalent way to increase access. This paper suggests increasing access through currently existing, local businesses where people already gather and where proprietors already posses existing business relationships with suppliers and customers. This paper questions the prevailing emphasis on the “cyber'' characteristics of access, e.g., computing and internet access as is currently known, and attempts to refocus the conversation by considering computing and access in the context of the “café,” e.g., as public life in the sense of Habermas, which permits an in situ evolution of relevant access. This analysis is based on extant literature and direct ethnographic research in several public places in six countries. We offer example design perspectives based on a reflection of “third places” as inspiration for appropriate innovation in the provision of computing and communications. © 2005 Wiley Periodicals, Inc.     

Advances and Perspectives in Dental Pulp Stem Cell Based Neuroregeneration Therapies

Human dental pulp stem cells (hDPSCs) are some of the most promising stem cell types for regenerative therapies given their ability to grow in the absence of serum and their realistic possibility to be used in autologous grafts. In this review, we describe the particular advantages of hDPSCs for neuroregenerative cell therapies. We thoroughly discuss the knowledge about their embryonic origin and characteristics of their postnatal niche, as well as the current status of cell culture protocols to maximize their multilineage differentiation potential, highlighting some common issues when assessing neuronal differentiation fates of hDPSCs. We also review the recent progress on neuroprotective and immunomodulatory capacity of hDPSCs and their secreted extracellular vesicles, as well as their combination with scaffold materials to improve their functional integration on the injured central nervous system (CNS) and peripheral nervous system (PNS). Finally, we offer some perspectives on the current and possible future applications of hDPSCs in neuroregenerative cell therapies.