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排序方式: 共有104条查询结果,搜索用时 31 毫秒
1.
The programmability of RNA–RNA interactions through intermolecular base-pairing has been successfully exploited to design a variety of RNA devices that artificially regulate gene expression. An in silico design for interacting structured RNA sequences that satisfies multiple design criteria becomes a complex multi-objective problem. Although multi-objective optimization is a powerful technique that explores a vast solution space without empirical weights between design objectives, to date, no web service for multi-objective design of RNA switches that utilizes RNA–RNA interaction has been proposed. We developed a web server, which is based on a multi-objective design algorithm called MODENA, to design two interacting RNAs that form a complex in silico. By predicting the secondary structures with RactIP during the design process, we can design RNAs that form a joint secondary structure with an external pseudoknot. The energy barrier upon the complex formation is modeled by an interaction seed that is optimized in the design algorithm. We benchmarked the RNA switch design approaches (MODENA+RactIP and MODENA+RNAcofold) for the target structures based on natural RNA-RNA interactions. As a result, MODENA+RactIP showed high design performance for the benchmark datasets. 相似文献
2.
Characterization of alternative plasticizers in poly(vinyl chloride) sheets for blood containers
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Yuji Haishima Tsuyoshi Kawakami Chie Fukui Akito Tanoue Toshiyasu Yuba Satoru Ozono Hidehumi Kumada Kaoru Inoue Tomomi Morikawa Miwa Takahashi Ayano Fujisawa Kayo Yamasaki Yusuke Nomura Kazuo Isama Ung‐il Chung Kumiko Ogawa Shingo Niimi Midori Yoshida 《乙烯基与添加剂工艺杂志》2016,22(4):520-528
This study aimed to optimize the ratio of dioctyl 4‐cyclohexene‐1,2‐dicarboxylate (DOTH) and di‐isononyl‐cyclohexane‐1,2‐dicarboxylate (DINCH®) for use as plasticizers in poly(vinyl chloride) (PVC) sheets. We also evaluated the biological safety of DOTH for its potential to be part of a safe PVC‐based blood container. The suppression of hemolysis in mannitol‐adenine‐phosphate / red cell concentrates (MAP/RCC) with DOTH/(DINCH®‐PVC) sheets and the elution of plasticizers from the sheets increased with higher DOTH compositions. The properties of the PVC sheet containing DOTH and DINCH® in the ratio of 25:33 parts against PVC 100 parts as a weight were almost identical to the PVC sheet made of di(2‐ethylhexyl) phthalate. From a subchronic toxicity test, DOTH did not show any adverse effects on all organs, including the testes, epididymis, liver, and kidneys. The no‐observed‐adverse‐effect level was 300 mg/kg body weight/day in a rat. These results suggest that DOTH/DINCH® (25:33) is a promising candidate for the replacement of di(2‐ethylhexyl) phthalate in blood containers. J. VINYL ADDIT. TECHNOL., 22:520–528, 2016. © 2015 Society of Plastics Engineers 相似文献
3.
Cheol Ho Pyeon Masao Yamanaka Akito Oizumi Masahiro Fukushima Go Chiba Kenichi Watanabe 《Journal of Nuclear Science and Technology》2019,56(8):684-689
This study demonstrates, for the first time, the principle of nuclear transmutation of minor actinide (MA) by the accelerator-driven system (ADS) through the injection of high-energy neutrons into the subcritical core at the Kyoto University Critical Assembly. The main objective of the experiments is to confirm fission reactions of neptunium-237 (237Np) and americium-241 (241Am), and capture reactions of 237Np. Subcritical irradiation of 237Np and 241Am foils is conducted in a hard spectrum core with the use of the back-to-back fission chamber that obtains simultaneously two signals from specially installed test (237Np or 241Am) and reference (uranium-235) foils. The first nuclear transmutation of 237Np and 241Am by ADS soundly implemented by combining the subcritical core and the 100 MeV proton accelerator, and the use of a lead-bismuth target, is conclusively demonstrated through the experimental results of fission and capture reaction events. 相似文献
4.
Among the innovative reactor concepts, CANDLE has several advantages over conventional reactor designs. However, when CANDLE is extended to long life, the clad integrity at high neutron fluence, the build-up of fission product gases, and the pressure drop for long cores pose technological challenges which have to be overcome. In this paper, we propose practically viable design procedures, such as recladding the entire fuel pins and replacement of different amounts of fuel at different radial positions, to ensure clad integrity and flat power distribution, respectively. We demonstrate the efficacy of such design procedures by calculations that are performed on a LBE CANDLE reactor. Our calculations show that for a reactor operation period of 3700 days the various reactor parameters are within the limits proposed by Japan Atomic Energy Agency (JAEA). 相似文献
5.
We attempted to produce a Ti45Zr38Ni17 bulk icosahedral (i) quasicrystal by a shock compression technique, in which a single-stage powder gun discharges a flyer plate that consolidates the target powders. The results were also compared with those by a conventional hot-pressing. The powder mixtures for the shock compression were blended by two kinds of methods; that is, gently mixing in a vial, and mechanically alloying by a planetary ball mill. A large bulk i-phase sample, with a Ti2Ni crystal phase, was synthesized from mechanically alloyed powders after shock compression at a higher flyer velocity, although the conventional hot-pressing at 3 MPa synthesized only the Ti2Ni phase. For the gently mixed powders, no reaction occured even after shock compression. High-pressure and high-temperature produced during shock compression, and milling process were key factors to obtain the i-phase. The Vickers hardness and the wetting contact angle with pure water under an atmospheric pressure for the bulk sample containing the i-phase were about 7 GPa and about 70°, respectively. 相似文献
6.
Jacques Calmet Peter Kullmann Morio Taneda 《Annals of Mathematics and Artificial Intelligence》2002,36(3):263-277
In a mediator system based on annotated logics it is a suitable requirement to allow annotations from different lattices in one program on a per-predicate basis. These lattices however may be related through common sublattices, hence demanding predicates which are able to carry combinations of annotations, or access to components of annotations. We show both demands to be satisifiable by using various composition operations on the domain of complete bounded distributive lattices or bilattices, most importantly the free distributive product. An implementation of the presented concepts, based on the KOMET implementation of SLG-AL with constraints, is briefly introduced. 相似文献
7.
Guoqing Guan Katsuki Kusakabe Haruka Ozono Masatsugu Taneda Masato Uehara Hideaki Maeda 《Journal of Materials Science》2007,42(24):10196-10202
Three-dimensionally (3D) well-ordered carbon microparticle assemblies with different particle morphologies were fabricated
by infiltration of phenolic resin solution into SiO2 inverse opal structures and subsequent carbonization. The effect of the phenolic resin solution concentration and the carbonization
temperature on the morphology of the fabricated carbon microparticles was investigated. At a carbonization temperature of
1000 °C, carbon microparticles with interlocked bridges were obtained when the concentration of phenolic resin solution is
40 wt% and hollow carbon microparticles with opened window channels were obtained at a concentration of 30–35 wt%. When the
carbonization temperature was decreased to 500 °C, carbon microparticles with interlocked bridges also were observed, even
when the phenolic resin concentration was 30 wt%. The structures and properties of the carbon microparticles and their assemblies
were characterized using SEM, XRD, and N2 adsorption. 相似文献
8.
Takahiro Yokoyama Akito Masuhara Tsunenobu Onodera Hitoshi Kasai Hidetoshi Oikawa 《Synthetic Metals》2009,159(9-10):897-899
Core/shell hybridized nanocrystals composed of Ag nanoparticle core and polydiacetylene shell were fabricated successfully by means of “co-reprecipitation/microwave irradiation method”. The hybridized nanocrystals were characterized using transmission electron microscopy (TEM) observation and UV–vis absorption spectroscopy. UV–vis spectral measurements revealed that polydiacetylene shell was the red phase while π-conjugated backbone is distorted. Detailed mechanism of formation of the red phase was discussed. 相似文献
9.
In this study, we introduced the temperaturedependent formation phases and crystallographic parameters of hot-pressed silver gallium telluride AgGaTe_2 and copper gallium telluride CuGaTe_2 with chalcopyrite structure from 300 to 800 K. These two compounds are potential thermoelectric materials in the intermediate temperature range; however, the temperature-dependent formation phases and crystallographic parameters of hotpressed samples have not yet been analyzed in detail. The crystal structure analysis based on synchrotron X-ray diffraction(SXRD) measurements clarifies that impurity phases such as Te and Ag_2 Te in the AgGaTe_2 matrix and Te and CuTe in the CuGaTe_2 matrix appear at some temperature regions above 300 K. The existence of such impurity phases could be correlated with the increases of the electrical resistivity and Seebeck coefficient of the samples after multiple measurement cycles of the temperature-dependent transport properties from 300 to 800 K.The tetragonal lattice parameters a and c, tetragonal lattice volume, thermal expansion coefficients, tetragonal distortion, anion displacement parameter, and isotropic displacement parameter of the hot-pressed AgGaTe_2 and CuGaTe_2 were also analyzed. These crystallographic parameters are expected to substantially affect the thermoelectric properties of AgGaTe_2 and CuGaTe_2. Our results provide prospect of the long-term high-temperature stability and clues of the detailed analysis on the transport properties of hot-pressed AgGaTe_2 and CuGaTe_2, which should aid their development for thermoelectric applications. 相似文献
10.
Norihito Mayama Hiroyuki Yoshida Tatsuo Iwata Kaoru Sasakawa Atsushi Suzuki Yuya Hanaoka Yoshihiro Morita Akito Kuroda Masanori Owari 《Diamond and Related Materials》2010,19(7-9):946-949
In this study, we report the characterization of carbonaceous films deposited on metal substrates by liquid-phase electrodeposition in methanol. The characterization of carbonaceous films by electrodeposition was examined by means of Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), electron energy loss spectroscopy (EELS), secondary ion mass spectrometry (SIMS), atom probe (AP) and high resolution-elastic recoil detection analysis (HR-ERDA). From these results, it was found that the films deposited on the metal substrates were composed of the sp2 and sp3 carbon contents, of which the ratio was about 7:3. Furthermore, the films by electrodeposition contained much hydrogen. The hydrogen contents in the surface were about 60 at.% and those in the subsurface were a few 10 at.%. 相似文献