Design,Synthesis, and Self-Assembly Studies of a Suite of Monodisperse,Facially Amphiphilic,Protein–Dendron Conjugates

The custom design of protein–dendron amphiphilic macromolecules is at the forefront of macromolecular engineering. Macromolecules with this architecture are very interesting because of their ability to self-assemble into various biomimetic nanoscopic structures. However, to date, there are no reports on this concept due to technical challenges associated with the chemical synthesis. Towards that end, herein, a new chemical methodology for the modular synthesis of a suite of monodisperse, facially amphiphilic, protein–dendron bioconjugates is reported. Benzyl ether dendrons of different generations (G1–G4) are coupled to monodisperse cetyl ethylene glycol to form macromolecular amphiphilic activity-based probes (AABPs) with a single protein reactive functionality. Micelle-assisted protein labeling technology is utilized for site-specific conjugation of macromolecular AABPs to globular proteins to make monodisperse, facially amphiphilic, protein–dendron bioconjugates. These biohybrid conjugates have the ability to self-assemble into supramolecular protein nanoassemblies. Self-assembly is primarily mediated by strong hydrophobic interactions of the benzyl ether dendron domain. The size, surface charge, and oligomeric state of protein nanoassemblies could be systematically tuned by choosing an appropriate dendron or protein of interest. This chemical method discloses a new way to custom-make monodisperse, facially amphiphilic, protein–dendron bioconjugates.     

利用精密仪表放大器实现负压电流检测

监测正电源的电流时，通常使用高边检流放大器。然而，对于ISDN、电信电源，通常需要一个工作在负电源的检流放大器。本文介绍了一种采用MAX4460单电源仪表放大器设计负压检流放大器的方法。     

EvoMiner: frequent subtree mining in phylogenetic databases

The problem of mining collections of trees to identify common patterns, called frequent subtrees (FSTs), arises often when trying to interpret the results of phylogenetic analysis. FST mining generalizes the well-known maximum agreement subtree problem. Here we present EvoMiner, a new algorithm for mining frequent subtrees in collections of phylogenetic trees. EvoMiner is an Apriori-like levelwise method, which uses a novel phylogeny-specific constant-time candidate generation scheme, an efficient fingerprinting-based technique for downward closure, and a lowest-common-ancestor-based support counting step that requires neither costly subtree operations nor database traversal. Our algorithm achieves speedups of up to 100 times or more over Phylominer, the current state-of-the-art algorithm for mining phylogenetic trees. EvoMiner can also work in depth-first enumeration mode to use less memory at the expense of speed. We demonstrate the utility of FST mining as a way to extract meaningful phylogenetic information from collections of trees when compared to maximum agreement subtrees and majority-rule trees—two commonly used approaches in phylogenetic analysis for extracting consensus information from a collection of trees over a common leaf set.     

Emergent Properties of the Public Realm and Encroachments in the Urban Environment

The declining quality of the public realm in urban environment is a matter of concern and is found to be encroached upon in Indian cities. There is an urgent need to address this issue, and it is challenging for urban designers. Adopting an analytic framework addressing this ever-changing nature of the public realm in practice would be instrumental in improving the quality of urban life at large. The public realm in an urban environment is considered as a complex system to observe the macro-level behaviour—emergent properties which are either encouraging or discouraging for encroachments assumed to be the function of micro-level behaviour—elementary properties of interconnected and interdependent individual elements. Owing to the impossibility of experimenting with these emergent properties in the real world, an agent-based model—“Emergent Properties of Public Realm 3.1”—was developed in NetLogo 4.1.3. The typical cases representing the encroached and the un-encroached public realm were identified in the real world and experiments were conducted with varied interaction constants assumed to represent the pace of change in an urban environment. The output generated by the agent-based model was analyzed with respect to the real world.     

A compact ACS-fed dual-band monopole antenna for LTE,WLAN/WiMAX and public safety applications

In this paper, a compact asymmetric coplanar strip (ACS)-fed printed monopole antenna for dual frequency operation is presented. The proposed antenna is composed of an ACS-fed monopole structure and two semi circle shaped radiating branches, which occupies a very small size of 13.4 × 22.7 mm² including the ground plane. By properly selecting the length and position of these branches, two desired operating bands can be achieved and tuned independently. The simulated and measured return loss results shows that the proposed antenna can be used for long term evolution 2500 (2500–2690 MHz), WLAN 5.2 GHz (5.15–5.35 GHz)/5.8 GHz (5.725–5.825 GHz), WiMAX 5.5 GHz (5.28–5.85 GHz) and 4.9 GHz (4.94–4.99 GHz) public safety applications. The omnidirectional and bidirectional radiation pattern characteristics in H-plane and E-plane of the proposed antenna along with acceptable peak gain make the best suitable candidate for the above intended applications.     

Targeting and design of energy allocation networks with carbon capture and storage

The mathematical formulation for targeting during energy allocation with carbon capture and storage (CCS) is formally developed. For operating-cost optimization with zero excess, it is shown that CCS sources may be regarded as resources with their cost taken as the increment over the non-CCS option. CCS sources along with clean-carbon resources may then be targeted by profile matching with the limiting composite to establish optimal primary cases. The limiting composite curve is itself sacrosanct and obtained by a single computation of the composite table algorithm (CTA) including only non-CCS sources. Carbon emission networks (CENs) are designed by the nearest neighbors algorithm (NNA). A cost criterion is established to determine cost-factor ranges for optimality of the primary cases, and results validated by solving linear programming (LP) and mixed integer linear programming (MILP) formulations. The methodology essentially comprises four distinct stages – targeting, network design, cost analysis, and optimization – with the first two stages not requiring any cost data.     

Rare earth (RE) doped phosphors and their emerging applications: A review

The evolution of luminescent materials has witnessed rapid advancement in research and development. Solid inorganic light-emitting materials or phosphors are the optoelectronic material of the 21st century because of their power-efficient potential over various illumination sources, eco-friendliness and resourceful display perspectives. The inorganic phosphors have been extensively explored to meet the demand of low voltage stimulated lighting sources owing to increased global energy consumption. Due to environmental friendliness, advantages long lifetime, lower energy consumption, reliability and high luminous efficiency, modern white light-emitting diodes (WLEDs) have replaced less effective incandescent and mercury-enclosing conventional fluorescent lighting sources. This review highlights the developments in preparation, luminescence and potential perceptions of rare-earth activated phosphors for solid-state lighting technologies. The role of RE ions as an activator as well as a sensitizer in doped materials and possible transitions within their energy levels are reviewed in detail. The paper reviews the substantial influence of host lattices such as aluminate, oxide, phosphate, silicate, sulfide, etc on the optical transitions of doped RE ions. Studies on the advancement into the design of novel phosphors are very crucial as they will provide an opportunity to boom prospects in the course of promising applications. The sustainable energy facilities include clean technologies providing a cheaper lighting source which can produce significant indirect economic benefits via limiting the deforestation and use of scrubbing technology to mitigate air pollution.     

Direct optical-structure correlation in atomically thin dichalcogenides and heterostructures

Atomically thin transition metal dichalcogenides (TMDs) have distinct opto-electronic properties including enhanced luminescence and high on-off current ratios, which can be further modulated by making more complex TMD heterostructures. However, resolution limits of conventional optical methods do not allow for direct nanoscale optical-structural correlation measurements in these materials, particularly of buried interfaces in TMD heterostructures. Here we use, for the first time, electron beam induced cathodoluminescence in a scanning transmission electron microscope (CL-STEM) to measure optical properties of monolayer TMDs (WS₂, MoS₂ and WSSe alloy) encapsulated between layers of hBN. We observe dark areas resulting from localized (~ 100 nm) imperfect interfaces and monolayer folding, which shows that the intimate contact between layers in this application-relevant heterostructure is required for proper inter layer coupling. We also realize a suitable imaging method that minimizes electron-beam induced changes and provides measurement of intrinsic properties. To overcome the limitation of small electron interaction volume in TMD monolayer (and hence low photon yield), we find that encapsulation of TMD monolayers with hBN and subsequent annealing is important. CL-STEM offers to be a powerful method to directly measure structure-optical correspondence in lateral or vertical heterostructures and alloys.