全文获取类型
收费全文 | 1251篇 |
免费 | 111篇 |
国内免费 | 1篇 |
专业分类
电工技术 | 29篇 |
化学工业 | 307篇 |
金属工艺 | 16篇 |
机械仪表 | 28篇 |
建筑科学 | 20篇 |
矿业工程 | 1篇 |
能源动力 | 34篇 |
轻工业 | 242篇 |
水利工程 | 9篇 |
石油天然气 | 4篇 |
无线电 | 104篇 |
一般工业技术 | 161篇 |
冶金工业 | 136篇 |
原子能技术 | 4篇 |
自动化技术 | 268篇 |
出版年
2024年 | 2篇 |
2023年 | 15篇 |
2022年 | 24篇 |
2021年 | 51篇 |
2020年 | 40篇 |
2019年 | 49篇 |
2018年 | 51篇 |
2017年 | 49篇 |
2016年 | 43篇 |
2015年 | 33篇 |
2014年 | 59篇 |
2013年 | 90篇 |
2012年 | 63篇 |
2011年 | 86篇 |
2010年 | 60篇 |
2009年 | 58篇 |
2008年 | 73篇 |
2007年 | 51篇 |
2006年 | 37篇 |
2005年 | 36篇 |
2004年 | 34篇 |
2003年 | 35篇 |
2002年 | 21篇 |
2001年 | 21篇 |
2000年 | 27篇 |
1999年 | 16篇 |
1998年 | 54篇 |
1997年 | 37篇 |
1996年 | 25篇 |
1995年 | 16篇 |
1994年 | 19篇 |
1993年 | 20篇 |
1992年 | 4篇 |
1991年 | 11篇 |
1990年 | 5篇 |
1989年 | 5篇 |
1988年 | 8篇 |
1987年 | 4篇 |
1986年 | 3篇 |
1985年 | 4篇 |
1984年 | 7篇 |
1983年 | 2篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1976年 | 5篇 |
1969年 | 1篇 |
排序方式: 共有1363条查询结果,搜索用时 15 毫秒
1.
Raquel Cano Jos L. Prez Liss Angarita Dvila ngel Ortega Yosselin Gmez Nereida Josefina Valero-Cedeo Heliana Parra Alexander Manzano Teresa Isabel Vliz Castro María P. Díaz Albornoz Gabriel Cano Joselyn Rojas-Quintero Maricarmen Chacín Valmore Bermúdez 《International journal of molecular sciences》2021,22(9)
Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disorder, affecting around 25% of the population worldwide. It is a complex disease spectrum, closely linked with other conditions such as obesity, insulin resistance, type 2 diabetes mellitus, and metabolic syndrome, which may increase liver-related mortality. In light of this, numerous efforts have been carried out in recent years in order to clarify its pathogenesis and create new prevention strategies. Currently, the essential role of environmental pollutants in NAFLD development is recognized. Particularly, endocrine-disrupting chemicals (EDCs) have a notable influence. EDCs can be classified as natural (phytoestrogens, genistein, and coumestrol) or synthetic, and the latter ones can be further subdivided into industrial (dioxins, polychlorinated biphenyls, and alkylphenols), agricultural (pesticides, insecticides, herbicides, and fungicides), residential (phthalates, polybrominated biphenyls, and bisphenol A), and pharmaceutical (parabens). Several experimental models have proposed a mechanism involving this group of substances with the disruption of hepatic metabolism, which promotes NAFLD. These include an imbalance between lipid influx/efflux in the liver, mitochondrial dysfunction, liver inflammation, and epigenetic reprogramming. It can be concluded that exposure to EDCs might play a crucial role in NAFLD initiation and evolution. However, further investigations supporting these effects in humans are required. 相似文献
2.
3.
Dr. Alejandra A. Carriles Alberto Mills Dr. María-José Muñoz-Alonso Dr. Dolores Gutiérrez Dr. Juan M. Domínguez Prof. Dr. Juan A. Hermoso Prof. Dr. Federico Gago 《Chembiochem : a European journal of chemical biology》2021,22(2):374-391
Spontaneous mutations in the EEF1A2 gene cause epilepsy and severe neurological disabilities in children. The crystal structure of eEF1A2 protein purified from rabbit skeletal muscle reveals a post-translationally modified dimer that provides information about the sites of interaction with numerous binding partners, including itself, and maps these mutations onto the dimer and tetramer interfaces. The spatial locations of the side chain carboxylates of Glu301 and Glu374, to which phosphatidylethanolamine is uniquely attached via an amide bond, define the anchoring points of eEF1A2 to cellular membranes and interorganellar membrane contact sites. Additional bioinformatic and molecular modeling results provide novel structural insight into the demonstrated binding of eEF1A2 to SH3 domains, the common MAPK docking groove, filamentous actin, and phosphatidylinositol-4 kinase IIIβ. In this new light, the role of eEF1A2 as an ancient, multifaceted, and articulated G protein at the crossroads of autophagy, oncogenesis and viral replication appears very distant from the “canonical” one of delivering aminoacyl-tRNAs to the ribosome that has dominated the scene and much of the thinking for many decades. 相似文献
4.
Meza-Espinoza Libier de los Ángeles Vivar-Vera María de Lourdes García-Magaña María Sáyago-Ayerdi Sonia G. Chacón-López Alejandra Becerrea-Verdín Eduardo M. Montalvo-González Efigenia 《Food science and biotechnology》2018,27(2):509-517
Food Science and Biotechnology - The enzymatic activity and partial characterization of proteases from Bromelia karatas fruits were evaluated and compared with Bromelia pinguin proteases. The... 相似文献
5.
Billardon M. Elleaume P. Ortega J. Bazin C. Bergher M. Velghe M. Deacon D. Petroff Y. 《Quantum Electronics, IEEE Journal of》1985,21(7):805-823
In this paper we review the results obtained in the last two years with the Orsay free electron laser. 相似文献
6.
RM Martín‐Aranda E Ortega‐Cantero ML Rojas‐Cervantes MA Vicente‐Rodríguez MA Baares‐Muoz 《Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986)》2005,80(2):234-238
α,β‐Unsaturated nitriles have been synthesized by Knoevenagel condensation of a carbonylic compound with malononitrile, assisted by sonochemical irradiation. Two alkaline‐promoted clays (Li+‐ and Cs+‐exchanged saponites) have been employed as catalysts. The influence of the carbonylic compound (benzaldehyde or cyclohexanone) and the use of a solvent on the catalytic activity have been studied. Remarkable increase in the conversion values has been found when the reaction is activated by ultrasound, as compared with the thermal activation. In this green, solvent‐free procedure, α,β‐unsaturated nitriles have been produced in very high yields (97%) when the Cs+‐saponite is used as catalyst. Copyright © 2004 Society of Chemical Industry 相似文献
7.
The stabilization problem for selected relative equilibria of an underactuated rigid body, modelling a simple underwater vehicle, moving in an ideal fluid is addressed. State feedback control laws achieving local asymptotic stability of a forward motion and of a diving/rising with forward/reverse motion are proposed. The control design exploits the Hamiltonian nature of the system to be controlled and it is based on the so-called interconnection and damping assignment (IDA) procedure. Simulation results complete the work. 相似文献
8.
9.
Vicente Rodríguez Montequín Francisco Ortega Fernández Nicolás Abajo de Martínez Juan Antonio González Rodríguez 《JOM Journal of the Minerals, Metals and Materials Society》2002,54(7):46-50
This research summary discusses the application of neural networks, evolutionary strategies, and other artificial intelligence
techniques in the modeling and optimization of the models used for temperature, rolling force, and torque calculation in heavy
plate milling. 相似文献
10.
J Moreno Sierra ML Maestro de las Casas J Chicharro Almarza MD Ortega Heredia J López García-Asenjo C Merino Sánchez E Blanco Jiménez A Silmi Moyano L Rsesel Estévez 《Canadian Metallurgical Quarterly》1997,50(8):855-866
OBJECTIVE: The clinical course of transitional cell carcinoma of the bladder can be difficult to predict due to its potential to invade the muscle layer and/or develop to a high grade lesion. Bladder carcinoma can arise from genetic changes that may activate the oncogenes (-c-erbB2, c-erbB1, c-myc, ras, etc.) and/or inactivate the suppressor genes (p53, Rb). The aim of the present study is to continue a study protocol on the molecular biology of bladder tumors. METHODS/RESULTS: From January, 1993 to January, 1995, 85 patients were studied. These patients were divided into two groups: the first group comprised 14 controls of urothelial tissue and the second comprised 65 cases of transitional cell carcinoma of the bladder. p53 expression was determined by an immunohistochemical method (NCL-p53-DO7 monoclonal antibody). Quantification of the p8 oncoprotein in cytosol and EGFR (epidermal growth factor receptor) in membrane was performed by ELISA (Oncogene Science) and RIA (Vienna Lab), respectively. A statistically significant relationship between the expression of p53 and EGFR with tumor stage and grade was found. Quantification of p185 and EGFR showed higher values in the tumor tissue than in the control samples, but a worse survival could not be determined. CONCLUSIONS: The present study shows that p53 expression can be considered to be a prognostic factor. It provides useful information on the aggressive behaviour of the tumor and has a direct relation with the survival rates. 相似文献