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排序方式: 共有527条查询结果,搜索用时 15 毫秒
1.
Pierre Santucci Christina Dedaki Alexandros Athanasoulis Laura Gallorini Anaïs Munoz Dr. Stéphane Canaan Dr. Jean-François Cavalier Dr. Victoria Magrioti 《ChemMedChem》2019,14(3):349-358
In the quest for new antibacterial agents, a series of novel long- and medium-chain mono- and disubstituted β-lactones was developed. Their activity against three pathogenic mycobacteria—M. abscessus, M. marinum, and M. tuberculosis—was assessed by the resazurin microtiter assay (REMA). Among the 16 β-lactones synthesized, only 3-hexadecyloxetan-2-one (VM005) exhibited promising activity against M. abscessus, whereas most of the β-lactones showed interesting activities against M. marinum, similar to that of the classical antibiotic, isoniazid. Regarding M. tuberculosis, six compounds were found to be active against this mycobacterium, with β-lactone VM008 [trans-(Z)-3-(hexadec-7-en-1-yl)-4-propyloxetan-2-one] being the best growth inhibitor. The promising antibacterial activities of the best compounds in this series suggest that these molecules may serve as leads for the development of much more efficient antimycobacterial agents. 相似文献
2.
Alexandros Papadopoulos Issaak Parcharidis Panagiotis Elias Pierre Briole 《International journal of remote sensing》2019,40(16):6365-6382
We analysed the ground deformation across two blocks defined by the Rio-Patras fault from 1993 to 2017 using multi-temporal Synthetic Aperture Radar Interferometry (InSAR) techniques. Our main objective was to contribute to the assessment of seismic hazard near the large city of Patras. Multiple data-sets were used, each one covering different temporal periods. Descending and ascending acquisitions, providing different viewing geometries contribute to fully determine the ground displacement in 3D. The data-sets used are from the European Space Agency’s (ESA) European Remote Sensing (ERS), Environmental Satellite (ENVISAT) and SENTINEL-1 as well as German Aerospace Center (DLR) ’s TERRASAR-X missions. Considering ESA’s missions covering both acquisition geometries and long periods, the southern block, showing lack of a sufficient number of scatterers does not allow the displacement characterization. In contrary, the northern block is characterized by a high number of scatterers having values of maximum likehood ranging from ?3.5 to ?4.3 mm year?1 for ascending geometry and from ?1.6 to ?2.7 mm year?1 for the descending one. The fact that both geometries show negative values of displacements are consistent with downlift movement and at the same time the quantitative differentiation probably indicates an horizontal component as well. 相似文献
3.
Suitability,efficiency and microbiological safety of novel physical technologies for the processing of ready‐to‐eat meals,meats and pumpable products 下载免费PDF全文
Alexandros Ch. Stratakos Anastasios Koidis 《International Journal of Food Science & Technology》2015,50(6):1283-1302
Consumer studies and market reports show an increase in consumption of ready‐to‐eat (RTE) foods. Although conventional processing technologies can in most cases produce safe products, they can also lead to the degradation of nutritional compounds and negatively affect quality characteristics. Consumers strongly prefer food that is minimally processed with the maximum amount of health‐promoting substances. Novel processing technologies as pre‐ or post‐treatment decontamination methods or as substitutes of conventional technologies have the potential to produce foods that are safe, rich in nutrient content and with superior organoleptic properties. Combining novel with conventional processes can eliminate potential drawbacks of novel technologies. This review examines available scientific information and critically evaluates the suitability and efficiency of various novel thermal and nonthermal technologies in terms of microbial safety, quality as well as nutrient content on the production of RTE meals, meats and pumpable products. 相似文献
4.
Bosacchi A. Franchi S. Gombia E. Mosca R. Fantini F. Menozzi R. 《Electronics letters》1993,29(8):651-653
Outstanding stability has been observed in Al/Al/sub x/Ga/sub 1-x/As and Al/GaAs/Al/sub x/Ga/sub 1-x/As (x=0.25) Schottky barriers prepared by depositing Al in situ by MBE on annealing up to 400 degrees C. Conventionally evaporated barriers have been fabricated and compared with epitaxial ones. The changes in barrier height and ideality factor induced by annealing are reported.<> 相似文献
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The paper deals with I/O versions of receding horizon controllers based on the minimization of multistep quadratic costs with the constraint that the terminal state goes to zero. The resulting control law yields stable closed-loop systems under sharp conditions. Simulation results are presented to both verify the theoretical analysis and relate the new control law with GPC 相似文献
7.
P Casolo D Mosca C Amorotti B Drei A Raspadori P Di Blasio E Ganz G De Luca G Colli R De Maria D Amuso 《Canadian Metallurgical Quarterly》1997,68(2):207-11; discussion 212
Primary and sole breast lymphoma is a very rare disease. With the review of our series of 616 cases operated on for breast cancer, only 3 cases (0.48%) of primary breast non-Hodgkin lymphoma (LNH) have been observed. The authors outline the problems concerning diagnosis and therapy of this rare disease: pathological and immunohistochemical aspects are discussed. They stress the importance of staging in order to plan a correct multidisciplinary approach. 相似文献
8.
F Mosca 《Canadian Metallurgical Quarterly》1994,14(5):525-533
Vestibular disorders may be treated by means of drugs, surgical tools or rehabilitation. Cervical electrostimulation may be regarded as physical therapy and its activity is connected to neural pathways between cervical receptors and vestibular nuclei. In present study electrodes were placed lateral to cervical column on the opposite side of vestibular deficit as pointed by electronystagmography; stimulus duration was 18 msec and frequency 100 Hz. Every stimulation lasts for 30 minutes and were repeated twice a week for a total number of 10. The ability to adjust vestibulo-ocular reflex was evaluated by means of a Compensatory Index. The following materials were enrolled in the study: 20 normal subjects were observed before and after a cycle of stimulations: 24 patients suffering from acute labyrinthitis or neuritis, 48 cervical vertigo, 8 cervical traumatic injures and 3 patients operated for acoustical neuroma. All these groups were coupled with control groups composed of the same pathology and the same number of subjects. Statistical treatment of reports was evaluated by t-student test before therapy after one month and after 3 months. Results point out good effects of electrostimulation on vestibulo-ocular reflex compensation, especially in cervical vertigo and labyrinthitis or neuritis with respect to control groups. No important results were obtained in neuroma group and in normal subjects. Electrostimulation may act on vestibular nuclei by direct spino-vestibular pathway but also by repeated decompensations mainly mediated via the cerebellum or spino-reticular connections. 相似文献
9.
Papatheodorou Nikolaos Kouroupetroglou Georgios Pino Alexandros Giannopoulos Panagiotis-Alexios Makris Gerasimos Papageorgiou Charalambos 《Universal Access in the Information Society》2021,20(2):321-331
Universal Access in the Information Society - We present an investigation of the systematic differences in upper limb motor skills between children with learning disabilities (LDs) and children... 相似文献
10.