Investigation of the potential of asymptotic homogenization for elastic composites via a three-dimensional computational study

Asymptotic homogenization is employed assuming a sharp length scale separation between the periodic structure (fine scale) and the whole composite (coarse scale). A classical approach yields the linear elastic-type coarse scale model, where the effective elastic coefficients are computed solving fine scale periodic cell problems. We generalize the existing results by considering an arbitrary number of subphases and general periodic cell shapes. We focus on the stress jump conditions arising in the cell problems and explicitly compute the corresponding interface loads. The latter represent a key driving force to obtain nontrivial cell problems solutions whenever discontinuities of the coefficients between the host medium (matrix) and the subphases occur. The numerical simulations illustrate the geometrically induced anisotropy and foster the comparison between asymptotic homogenization and well established Eshelby based techniques. We show that the method can be routinely implemented in three dimensions and should be applied to hierarchical hard tissues whenever the precise shape and arrangement of the subphases cannot be ignored. Our numerical results are benchmarked exploiting the semi-analytical solution which holds for cylindrical aligned fibers.     

Raman investigation of single oxidized carbon nanotubes

The oxidation process of single-walled carbon nanotubes via nitric acid treatment was followed by IR-, UV-Vis-NIR, and single bundle Raman spectroscopy. The introduction of functional, oxygen-containing groups is revealed by an additional absorption band at 1725 cm⁻¹, characteristic of carbonyl stretch vibrations. No significant shift of the optical absorption bands could be detected after oxidation. The combination of atomic force microscopy and confocal scanning resonance-enhanced Raman microscopy was used to investigate thin bundles and, eventually, individual nanotubes in detail. These experiments enabled determination of the dependence of the Raman intensity of the G-line (around 1590 cm⁻¹) on the bundle height for both non-oxidized and oxidized tubes. The Raman cross-section of the oxidized tubes was found to be reduced by a factor of ˜4, compared to the pristine tubes. This observation is ascribed to all tubes within a bundle that are oxidized to the same degree.     

In Memory of Our Great Friend Professor Dong Haishan

In October 1987 an international symposium on propellants, explosives and pyrotechnics was arranged in Beijing at the Beijing Institute of Technology. I participated in that symposium and presented a paper entitled "Sensitivity Test Methods for approval of Explosives in Sweden".     

Critical Evaluation of Current Hypotheses for the Pathogenesis of Hypertrophic Cardiomyopathy

Hereditary hypertrophic cardiomyopathy (HCM), due to mutations in sarcomere proteins, occurs in more than 1/500 individuals and is the leading cause of sudden cardiac death in young people. The clinical course exhibits appreciable variability. However, typically, heart morphology and function are normal at birth, with pathological remodeling developing over years to decades, leading to a phenotype characterized by asymmetric ventricular hypertrophy, scattered fibrosis and myofibrillar/cellular disarray with ultimate mechanical heart failure and/or severe arrhythmias. The identity of the primary mutation-induced changes in sarcomere function and how they trigger debilitating remodeling are poorly understood. Support for the importance of mutation-induced hypercontractility, e.g., increased calcium sensitivity and/or increased power output, has been strengthened in recent years. However, other ideas that mutation-induced hypocontractility or non-uniformities with contractile instabilities, instead, constitute primary triggers cannot yet be discarded. Here, we review evidence for and criticism against the mentioned hypotheses. In this process, we find support for previous ideas that inefficient energy usage and a blunted Frank–Starling mechanism have central roles in pathogenesis, although presumably representing effects secondary to the primary mutation-induced changes. While first trying to reconcile apparently diverging evidence for the different hypotheses in one unified model, we also identify key remaining questions and suggest how experimental systems that are built around isolated primarily expressed proteins could be useful.     

Goat milk consumption protects DNA against damage induced by chronic iron overload in anaemic rats

The effect of cow or goat milk-based diets, either normal or Fe-overloaded, on DNA stability was studied in control and anaemic rats for 30 or 50 days of chronic Fe repletion. DNA damage was assessed using the alkaline comet assay. Background DNA damage in lymphocytes of peripheral blood was much lower in control and anaemic rats, given the normal or Fe-overloaded goat milk-based diet after 30 and 50 days versus cow milk-based diet. Chronic Fe-overload had no adverse effect on DNA stability in control and anaemic fed the goat milk-based diet versus the same diet with normal-Fe content at the end of the study. The quality of goat milk fat, together with the high levels of bioavailable Mg and Zn may be responsible for its protective effect on DNA of peripheral blood lymphocytes under the different experimental conditions, even during chronic Fe-overload.     

Interactions among iron, calcium, phosphorus and magnesium in the nutritionally iron-deficient rat

We studied the development of nutritional iron deficiency 0, 10, 20, 30 and 40 days after the intake of a semisynthetic diet lacking iron (diet 0) and the possible interactions with calcium, phosphorus and magnesium in both control rats and rats after 40 days of iron deficiency. During this period, iron deficiency was found to produce stress in the rats, as evidenced by high levels of cortisol in the serum. High levels of parathyroid hormone (PTH) were also found. There was a considerable increase in the absorption of calcium, phosphorus and magnesium, but the phosphorus and magnesium balance decreased and that of calcium remained practically unchanged, although there was an increase in calcium urinary elimination. Despite the noticeable degree of bone demineralization, which was evident in the femur, serum levels of calcium, phosphorus and magnesium remained constant. The present study shows that severe nutritional ferropenic anaemia provokes significant alterations in the metabolism of calcium, phosphorus and magnesium. We conclude that these alterations should be taken into account in the treatment of this pathology, given its prevalence and the fact that it may exacerbate other pathologies, particularly those related to the metabolism of calcium and phosphorus.     

Validity, predictive efficiency, and practical significance of selection tests.

The acceptance of validity coefficients at face value as measures of practical significance is evaluated by examining each functional relationship between 3 indexes of predictive efficiency r, r2, and E and 3 measures of practical significance the increase of the criterion mean, the expected proportion "satisfactory," and the expected proportion in 10 criterion categories. The validity coefficient, r is a linear function of the increase of the criterion mean and very nearly a linear function of the other 2 measures of practical significance; r2 and E are related to these 3 measures in a more curvilinear manner. A table is presented that gives the proportion expected in each of 18 criterion categories as a function of r and the selection ratio. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The mechanism of failure in bending of paperboard

The behaviour of paperboard beams subjected to pure bending is analysed and related to tensile and compression stress-strain behaviour. Since the compression strength is lower than the tensile strength, beam failure occurs in compression. However, beam failure does not occur when the ultimate strain in pure compression is reached in the surface fibres. A plastic yielding in compression, which gives good agreement between experimentally-determined and theoretically-calculated bending moments up to failure is therefore suggested. At failure, the elastic energy stored in the sample causes propagation of an interlaminar crack at the compression side, which is observed in scanning electron micrographs.     

A survey on histological image analysis-based assessment of three major biological factors influencing radiotherapy: proliferation, hypoxia and vasculature

Image analysis is a rapidly evolving field with growing applications in science and engineering. In cancer research, it has played a key role in advancing techniques of major diagnostic importance, minimising human intervention and providing vital clinical information. Especially in the field of tissue microscopy, the use of computers for the automated analysis of histological sections is becoming increasingly important. This paper presents an overview of various image analysis methodologies and summarises developments in this field, with great emphasis given on the assessment of three major biological factors known to influence the outcome of radiotherapy: proliferation, vasculature and hypoxia. A brief introduction followed by a survey is provided in each of these areas.