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排序方式: 共有174条查询结果,搜索用时 15 毫秒
1.
Rizwan Ullah Khan Haojie Yu Li Wang Lisong Teng Zain-ul-Abdin Ahsan Nazir Shah Fahad Tarig Elshaarani Fazal Haq Di Shen 《应用聚合物科学杂志》2020,137(46):49424
The development of safe drug carriers is cardinal in cancer therapy, which can target the cancer cells and release the loaded drug on-demand without damaging the healthy cells of the body. In our work, we synthesized three different biodegradable polymers, poly[(ethyl aminobezoate) (ethyl glycinato) phosphazenes] (PABGPs), in different mole ratio of side groups. The successful synthesis of these PABGPs was confirmed by 1H NMR, 31P NMR, FT-IR, and gel permeation chromatography. These PABGPs were fabricated into drug (camptothecin, CPT, a hydrophobic anticancer drug) loaded nanoparticles. These drug-loaded nanoparticles showed good drug release behaviors under normal physiological conditions (pH 7.4 and temperature 37°C). These PABGPs-based nanoparticles may find their application as effective drug carriers for cancer therapy. 相似文献
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Qaisra Fazal Arnold Neumaier 《Soft Computing - A Fusion of Foundations, Methodologies and Applications》2013,17(8):1345-1356
The computation of the error bounds for approximate solutions of initial value problems for ordinary differential equations has a long and successful history. This paper presents a new scheme to compute such bounds with uncertain initial conditions using preconditioned defect estimates and optimization techniques. These bounds are based on the newly developed concept of conditional differential inequalities. The scheme is implemented in MATLAB and AMPL. The resulting enclosures are compared with the packages VALENCIA-IVP, VNODE-LP and VSPODE for bounding solutions of ODEs. The current prototype uses heuristics to solve the global optimization subproblems. Hence the bounds obtained in the numerical experiments are not fully rigorous. The latter can be achieved by using rigorous global optimization and rounding error control, but the effect on the bounds is likely to be marginal only. 相似文献
5.
Fazal Abbas Qaisar Maqbool Mudassar Nazar Nyla Jabeen Syed Zaheer Hussain Sadaf Anwaar Nasir Mehmood Muhammad Saleem Sheikh Talib Hussain Sidra Iftikhar 《IET nanobiotechnology / IET》2017,11(8):935
To grapple with multidrug resistant bacterial infections, implementations of antibacterial nanomedicines have gained prime attention of the researchers across the globe. Nowadays, zinc oxide (ZnO) at nano‐scale has emerged as a promising antibacterial therapeutic agent. Keeping this in view, ZnO nanostructures (ZnO‐NS) have been synthesised through reduction by P. aphylla aqueous extract without the utilisation of any acid or base. Structural examinations via scanning electron microscopy (SEM) and X‐ray diffraction have revealed pure phase morphology with highly homogenised average particle size of 18 nm. SEM findings were further supplemented by transmission electron microscopy examinations. The characteristic Zn–O peak has been observed around 363 nm using ultra‐violet–visible spectroscopy. Fourier‐transform infrared spectroscopy examination has also confirmed the formation of ZnO‐NS through detection of Zn–O bond vibration frequencies. To check the superior antibacterial activity of ZnO‐NS, the authors'' team has performed disc diffusion assay and colony forming unit testing against multidrug resistant E. coli, S. marcescens and E. cloacae. Furthermore, protein kinase inhibition assay and cytotoxicity examinations have revealed that green fabricated ZnO‐NS are non‐hazardous, economical, environmental friendly and possess tremendous potential to treat lethal infections caused by multidrug resistant pathogens.Inspec keywords: nanomedicine, zinc compounds, II‐VI semiconductors, wide band gap semiconductors, nanoparticles, scanning electron microscopy, X‐ray diffraction, antibacterial activity, transmission electron microscopy, particle size, Fourier transform infrared spectra, ultraviolet spectra, visible spectra, enzymes, biochemistry, molecular biophysics, microorganisms, drugs, toxicology, bonds (chemical), semiconductor growth, nanofabrication, vibrational modesOther keywords: green synthesised zinc oxide nanostructures, Periploca aphylla extract, antibacterial potential, multidrug resistant pathogens, multidrug resistant bacterial infections, antibacterial nanomedicines, P. aphylla aqueous extract, structural examinations, scanning electron microscopy, X‐ray diffraction, pure phase morphology, homogenised average particle size, SEM, transmission electron microscopy, Fourier‐transform infrared spectroscopy, bond vibration frequency, antibacterial activity, disc diffusion assay, colony forming unit testing, S. marcescens, E. cloacae, E. coli, ultraviolet‐visible spectroscopy, protein kinase inhibition assay, cytotoxicity, lethal infections, ZnO 相似文献
6.
What failure analysis can do for the machine designer,operator, diagnostician,and prognostician 总被引:1,自引:0,他引:1
D. Aliya 《Journal of Failure Analysis and Prevention》2004,4(4):50-57
A competent failure analyst can often determine whether the machine design was nominally adequate with a half hour time slot
for visual examination. The use of macrofractography, a specialized type of visual examination, can allow trained personnel
to determine whether improper alignment or component imperfections may have contributed to an unexpected failure. Case studies
will be presented. Some examples of “learning from the graveyard” and how that can facilitate improvements in design, manufacturing,
and operations will be described.
Reprinted with permission from Proceeding of the 58th Meeting of the Society for Machinery Failure Prevention Technology, April 2004, p. 329. 相似文献
7.
Nazish Jahan Saba Aslam Khalil ur Rahman Tuba Fazal Fareeha Anwar Rubab Saher 《Journal of Experimental Nanoscience》2016,11(1):72-80
Nanotechnology is a promising technique to increase the bioavailability of herbal medicines. This paper presents the nanosuspension approach for increasing the aqueous solubility and thereby bioactivity of important herbal extracts. Nanosuspensions of the seeds of three plants extract (Silybum marianum, Elettaria cardamomum and Coriandrum sativum) were prepared by using polyvinyl alcohol (1.5% w/v) as a stabiliser. Prepared nanoparticles were characterised by scanning electron microscope. Activity of nanosuspension formulation was assessed by using four in vitro antioxidant assays. S. marianum, E. cardamomum and C. sativum particle size was observed to fall in range of 446.1 ± 112.6, 456.63 ± 339.2 and 432.1 ± 172.8 nm, respectively, most of the particles were having spherical shape and smooth topology. These synthesised nanoparticles were found to be more effective against quenching free radical than their crude extracts and standards [butylated hydroxyl toluene and ascorbic acid]. C. sativum nanosuspension showed most free radical scavenging potential against 2,2-diphenyl-1-picrylhdrazyl (DPPH) and superoxide free radical scavenging assays (IC50 0.59 ± 0.01 and 0.81 ± 0.11 mg/ml). S. marianum nanosuspension was found to be most effective against DPPH radicals scavenging (IC50 0.34 ± 0.02 mg/ml). It was concluded that nanosuspension of herbal medicines potentiates the antioxidant potential. 相似文献
8.
Biodiesel, as an alternative fuel, is gradually receiving more popularity for use in internal combustion engines. However questions continue to arise with regard to its compatibility with elastomeric materials. The present work aims to investigate the comparative degradation of physical properties for different elastomers [e.g. ethylene propylene diene monomer (EPDM), silicone rubber (SR), polychloroprene (CR), polytetrafluroethylene (PTFE) and nitrile rubber (NBR)] upon exposure to diesel and palm biodiesel. Static immersion tests in B0(diesel), B10 (10% biodiesel in diesel), B20, B50 and B100(biodiesel) were carried out at room temperature (25 °C) for 1000 h. Different physical properties like, changes in weight and volume, hardness and tensile strength were measured at every 250 h of immersion time. Compositional changes in biodiesel due to exposure of different elastomers were investigated by Gas chromatography mass spectroscopy (GCMS). The overall sequence of compatible elastomers in palm biodiesel is found to be PTFE > SR > NBR > EPDM > CR. 相似文献
9.
Abul Fazal M. Arif 《Journal of Mechanical Science and Technology》2009,23(10):2603-2611
Laser shock processing (LSP) involves high-energy laser radiation combined with suitable overlays to generate high-pressure
pulses on the surface of the metal. The stress wave generated due to high pressure pulses propagates into the material causing
the surface layer to yield and plastically deform, and thereby, develop a significant residual compressive stress in the surface
region of the substrate material. The developed compressive stress field is beneficial to improve surface properties such
as fatigue, wear, and corrosion. To improve the understanding of the shock hardening process, investigation into the physical
processes involved is necessary. In the first part of this paper, the temporal variation in the pressure intensity and spot
size is calculated by using a two-dimensional recoil pressure prediction model. Using an explicit non-linear FEA code, ANSYS
LS-DYNA, the deformation behavior and residual stresses in the substrate material are predicted. In the second part, a probabilistic
approach to the modeling and analysis of LSP is presented in this paper. Various factors that affect the probabilistic performance
of the LSP are grouped into categories and a select number of factors known to be significant, for which the variability could
be assessed, are modeled as random variables (such as recoil pressure, laser beam spot size, substrate material properties
and others). The potential of the probabilistic approach in predicting the structural integrity of the laser-shocked components
is addressed. 相似文献
10.
Cole PA Courtney AD Shen K Zhang Z Qiao Y Lu W Williams DM 《Accounts of chemical research》2003,36(6):444-452
Protein phosphorylation catalyzed by protein kinases plays a critical role in cellular signaling. Here we review several chemical approaches to understanding protein kinases and the consequences of protein phosphorylation. We discuss the design of bisubstrate analogue inhibitors based on a dissociative transition state, the development of reagents for cross-linking protein kinases with their substrates, the chemical rescue of mutant protein tyrosine kinases, and the application of expressed protein ligation to understanding protein phosphorylation. 相似文献