Tests of assumptions about the joint receipt of gambles in rank- and sign-dependent utility theory.

A rank- and sign-dependent utility theory is based on an operation of joint receipt of 2 independent gambles and 3 assumptions regarding the operation (R. D. Luce, 1992). The authors tested these 3 assumptions (i.e., segregation, duplex decomposition, and the additivity of certainty equivalents over joint receipt) using both judged and choice certainty equivalents (CEs). Median choice CEs provided support for both segregation and duplex decomposition but little support for additivity in gains or in losses, whereas median judged CEs also failed to support segregation. The latter failure appears to result from some Ss misunderstanding the instructions. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

MODELING WATER LOSS DURING FRYING OF POTATO STRIPS: EFFECT OF SOLUTE IMPREGNATION

The effect of solute impregnation on water loss and oil uptake during potato strip frying was studied. Blanched potato strips were impregnated at 25°C by soaking in a solution of sucrose-NaCl-water, 20-5-75% by weight. After rinsing and air drying, strips were deep fried in sunflower oil at 160, 170 and 180°C. A control treatment, consisting of potato strips blanched but not soaked and later air dried was also conducted. Solute impregnation provided a decrease of the oil uptake. Two models, based on Fick's law were used to describe water loss during frying. The first one is the classic model with an effective moisture diffusion coefficient assumed a constant value. The second model considers that diffusion coefficient varies during the frying process. For a given frying temperature, constant diffusion coefficient for control potatoes resulted in lower values than the impregnated ones. The variable diffusivity model showed a two-stage behavior: during the first stage of frying, diffusion coefficient increased with frying temperatures, but from a given time on an inverse behavior began. This last fact was found to be related to an increase of the measured peak force needed to penetrate the potato crust.     

Sorafenib delivery nanoplatform based on superparamagnetic iron oxide nanoparticles magnetically targets hepatocellular carcinoma

Currently,sorafenib is the only systemic therapy capable of increasing overall survival of hepatocellular carcinoma patients.Unfortunately,its side effects,particularly its overall toxicity,limit the therapeutic response that can be achieved.Superparamagnetic iron oxide nanoparticles (SPIONs) are very attractive for drug delivery because they can be targeted to specific sites in the body through application of a magnetic field,thus improving intratumoral accumulation and reducing adverse effects.Here,nanoformulations based on polyethylene glycol modified phospholipid micelles,loaded with both SPIONs and sorafenib,were successfully prepared and thoroughly investigated by complementary techniques.This nanovector system provided effective drug delivery,had an average hydrodynamic diameter of about 125 nm,had good stability in aqueous medium,and allowed controlled drug loading.Magnetic analysis allowed accurate determination of the amount of SPIONs embedded in each micelle.An in vitro system was designed to test whether the SPION micelles can be efficiently held using a magnetic field under typical flow conditions found in the human liver.Human hepatocellular carcinoma (HepG2) cells were selected as an in vitro system to evaluate tumor cell targeting efficacy of the superparamagnetic micelles loaded with sorafenib.These experiments demonstrated that this delivery platform is able to enhance sorafenib's antitumor effectiveness by magnetic targeting.The magnetic nanovectors described here represent promising candidates for targeting specific hepatic tumor sites,where selective release of sorafenib can improve its efficacy and safety profile.     

Synthetic handwritten CAPTCHAs

CAPTCHAs (completely automated public Turing test to tell computers and humans apart) are in common use today as a method for performing automated human verification online. The most popular type of CAPTCHA is the text recognition variety. However, many of the existing printed text CAPTCHAs have been broken by web-bots and are hence vulnerable to attack. We present an approach to use human-like handwriting for designing CAPTCHAs. A synthetic handwriting generation method is presented, where the generated textlines need to be as close as possible to human handwriting without being writer-specific. Such handwritten CAPTCHAs exploit the differential in handwriting reading proficiency between humans and machines. Test results show that when the generated textlines are further obfuscated with a set of deformations, machine recognition rates decrease considerably, compared to prior work, while human recognition rates remain the same.     

Genetic LGALS1 Variants Are Associated with Heterogeneity in Galectin-1 Serum Levels in Patients with Early Arthritis

Galectin 1 (Gal1) exerts immunomodulatory effects leading to therapeutic effects in autoimmune animal models. Patients with rheumatoid arthritis have been reported to show higher Gal1 serum levels than the healthy population. Our study aimed to find genetic variants on the Gal1 gene (LGALS1) modulating its expression and/or clinical features in patients with early arthritis (EA). LGALS1 was sequenced in 53 EA patients to characterize all genetic variants. Then, we genotyped rs9622682, rs929039, and rs4820293, which covered the main genetic variation in LGALS1, in 532 EA patients. Gal1 and IL-6 serum levels were measured by ELISA and Gal1 also by western blot (WB) in lymphocytes from patients with specific genotypes. Once disease activity improved with treatment, patients with at least one copy of the minor allele in rs9622682 and rs929039 or those with GG genotype in rs4820293 showed significantly higher Gal1 serum levels (p < 0.05). These genotypic combinations were also associated with higher Gal1 expression in lymphocytes by WB and lower IL-6 serum levels in EA patients. In summary, our study suggests that genetic variants studied in LGALS1 can explain heterogeneity in Gal1 serum levels showing that patients with higher Gal1 levels have lower serum IL-6 levels.     

Shelf life of ready‐to‐cook cauliflower mixtures as affected by packaging film mass transport properties

In this work, the influence of packaging mass transport properties on quality loss of fresh‐cut cauliflower mixtures was addressed. The study was organised in two subsequent experimental steps; first, the selection of micro‐perforated packaging films was carried out by monitoring the package headspace gas concentrations of fresh‐cut white, green cauliflower and roman cabbage. Then, the effects of the barrier properties of the selected micro‐perforated film on shelf life of two different fresh‐cut cauliflower mixtures, stored at 4 ± 1 °C, were addressed. Results suggested that, among the investigated films, the micro‐perforated polymeric matrix with the lowest oxygen transmission rate value showed the best performance as it created the optimum headspace gas composition for each cauliflower variety, as well as, for the product mixtures. The appearance of visible moulds was the factor limiting product shelf life that accounted for about 18 days for both the investigated cauliflower mixtures.     

Planning Belgian Congo’s network of medical infrastructure: type-plans as tools to construct a medical model-colony, 1949–1959

ABSTRACT

Throughout the 1950s, the Belgian colonial government constructed a vast network of hospital infrastructure as part of its Ten-Year Plan, a colony-wide socio-economic scheme emblematic for the era of ‘welfare colonialism.’ This network played a key role in Belgian colonialism, by providing healthcare, but also by boosting labour productivity, facilitating state presence and control, and by advertising Congo as a medical model-colony. In this article, we unpack the extensive administrative apparatus that was necessary to buttress this ambitious building programme, and we highlight type-plans as crucial government tools to construct such a vast network of healthcare infrastructure. At first glance, the use of type-plans confirms classic characterizations of the Belgian colonial government as an omnipotent and technocratic state apparatus that implemented large, top-down government plans through authoritative methods, often discarding local realities. However, tracing hospital construction on the ground reveals that type-plans did not function as immutable models, but rather as modular blueprints that allowed local administrations to adapt hospitals to local needs and contingencies. As such, our article illustrates how, facilitated by surprisingly flexible type-plans, everyday colonial policymaking in Belgian Congo was, contrary to the still dominant discourse, deeply reliant on the agency and aptitude of local officials.     

Chemical Composition and Physical Properties of High Oleic Safflower Oils (Carthamus tinctorius,Var. CW88-OL and CW99-OL)

Chemical composition and physical properties of CW88‐OL and CW99‐OL cultivars of high oleic safflower seeds and their hexane‐extracted oils were determined. Dry‐based seed composition of CW88‐OL and CW99‐OL was: moisture = 4.29 and 4.23 %, oil = 42.29 and 46.44 %, Crude protein = 20.94 and 16.41 %, neutral detergent fiber = 28.11 and 28.49 %, ash = 1.55 and 2.01 %, phosphorus content = 2033 and 3995 mg/kg, respectively. Major fatty acids in oils were ~78 % oleic (O), ~13 % linoleic (L), ~5 % palmitic (P) and ~2 % stearic (St) acids, for both cultivars. The main triacylglycerols were OOO (~50 %), OOL (~20 %), SOL + OPO (~10 %), and LLP (~5 %). The oil composition of CW88‐OL and CW99‐OL in main minor components was: α‐tocopherol = 582 and 551 mg/kg, total sterols = 3996 and 3362 mg/kg, phospholipids = 22 and 21 mg/kg and wax content = 70 and 74 mg/kg. For both cultivars, density and viscosity of the oils between 25 and 55 °C varied from 903.4 to 912.6 kg/m³ and 63 to 23 mPa.s showing linear and exponential behaviors, respectively. The refractive index was 1.4694. The CIELab color parameters were: 89.69 and 89.53 (L*), ?3.72 and ?3.07 (a*), and 47.28 and 47.78 (b*) (CW88‐OL and CW99‐OL, respectively). Thus, the high oil content of the seeds and nutritional quality of the oil accompanied by low levels of waxes and phospholipids makes the cultivars studied promising for producers and consumers.     

Control structure synthesis for operational optimization of mixed refrigerant processes for liquefied natural gas plant

The best control structures for the energy optimizing control of propane precooled mixed refrigerant (C₃MR) processes were examined. A first principles‐based rigorous dynamic model was developed to analyze the steady‐state and dynamic behaviors of the C₃MR process. The steady‐state optimality of the C₃MR process was then examined in a whole operation space for exploring the feasibility of the energy optimizing control for possible control structures. As a result, the temperature difference (TD) between the warm‐end inlet and outlet MR streams was exploited as a promising controlled variable to automatically keep the liquefaction process close to its optimum. The closed‐loop responses were finally evaluated for every possible control structure candidate. Based on the steady‐state optimality and the dynamic performance evaluation, several control structures with a TD loop were proposed to be most favorable for the energy optimizing control of the C₃MR process. The proposed optimality approach can be applied to any natural gas liquefaction process for determining a proper controlled variable for optimizing operation. © 2014 American Institute of Chemical Engineers AIChE J, 60: 2428–2441, 2014