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排序方式: 共有258条查询结果,搜索用时 15 毫秒
1.
The aim of this paper is to assess the state-of-the-art in the Decision Support Systems (DSS) field from both a research and a practice perspective. Three main dimensions of DSS research and practice are addressed: 1) supporting human decision-making processes, 2) integrating DSS into the organizational context, and 3) identifying new application domains. The related analysis and discussion provides a better understanding of past developments in the DSS field and insights into future evolution patterns. 相似文献
2.
Magdy Tawfik Hanna 《Digital Signal Processing》2012,22(4):681-689
The recent emergence of the discrete fractional Fourier transform has spurred research activity aiming at generating Hermite–Gaussian-like (HGL) orthonormal eigenvectors of the discrete Fourier transform (DFT) matrix F. By exploiting the unitarity of matrix F – resulting in the orthogonality of its eigenspaces pertaining to the distinct eigenvalues – the problem decouples into finding orthonormal eigenvectors for each eigenspace separately. A Direct Sequential Evaluation by constrained Optimization Algorithm (DSEOA) is contributed for the generation of optimal orthonormal eigenvectors for each eigenspace separately. This technique is direct in the sense that it does not require the generation of initial orthonormal eigenvectors as a prerequisite for obtaining the final optimal ones. The resulting eigenvectors are optimal in the sense of being as close as possible to samples of the Hermite–Gaussian functions. The technique is found to be numerically robust because total pivoting is allowed in performing the QR matrix decomposition step. The DSEOA is proved to be theoretically equivalent to each of the Gram–Schmidt algorithm (GSA) and the sequential orthogonal Procrustes algorithm (SOPA). However the three techniques are algorithmically quite distinct. An extensive comparative simulation study shows that the DSEOA is by far the most numerically robust technique among all sequential algorithms thus paying off for its relatively long computation time. 相似文献
3.
Abouelnaga Amal M. Meaz Talaat M. Othman Abdelmageed M. Ghazy Riyad A. El Nahrawy Amany M. 《SILICON》2021,13(3):623-631
Silicon - The nature of the opening silicate- based surface affects the chemical interaction, spectroscopic and antimicrobial efficiency. The aim of this approach was to evaluate the spectroscopic... 相似文献
4.
El Nahrawy Amany M. Hemdan Bahaa A. Abou Hammad Ali B. Othman Abdelmageed M. Abouelnaga Amal M. Mansour A. M. 《SILICON》2021,13(9):2979-2991
Silicon - Magnesium calcium silicate nanostructures (MCSNS) loaded with (0.0, 0.6, 0.9, and 1.2 wt%) of Cephradine-drug consisting of mesoporous particles were functionally prepared by sol-gel... 相似文献
5.
Yue?Hung K.?M.?EL-KhatibEmail author Hazem?Tawfik 《Journal of Applied Electrochemistry》2005,35(5):445-447
Corrosion resistant treated metal bipolar plates with higher rigidity and electrical conductivity than graphite were developed and tested for PEM fuel cell applications. Six replicas of single cells were used three of which were made of graphite composites bipolar plates and the other three of the treated metallic plates. A Membrane Electrode Assembly (MEA) with 5.55 cm2 active electrode areas, 0.3 mg cm–2 Pt loading and Nafion membrane 115 was fitted to each cell and operated under identical conditions. The experimental testing was conducted at room temperature (20 °C). The average value of the data obtained for the three graphite cells was plotted. Similarly, the average value of the data obtained for the three treated metal cells was plotted on the same graph for comparison. Generally, the treated metal bipolar plate provided at least 12% saving in hydrogen consumption in comparison to graphite. This is attributed to the lower bulk and surface contact resistance of the metal used in this study in relation to graphite. The results of lifetime testing, conducted at room temperature under variable loading showed no indication of power degradation due to metal corrosion for at least 1500 hours. 相似文献
6.
ABSTRACTIn this study, an Egyptian siliceous/calcareous sedimentary phosphorite was subjected to beneficiation by unsophisticated economic means. The mineralogical and chemical examination showed that the ore sample is a typical example for the East Mediterranean phosphorites with 21.80% P2O5, 10.93% acid insoluble and 16.61% loss on ignition. The primary crushed sample was classified into three size fractions without any milling and they were separately subjected to an integrated attrition scrubbing study. Screening and classification on the 2.30 mm and 0.071 mm sieves were sequentially introduced with the attrition process. The effect of solid%, attrition speed and time were studied and optimized for each size fraction. Results showed that three products were produced and could be categorized according to their P2O5 content into the coarse tailing (+2.30 mm), the attrition concentrate (?2.30 + 0.071 mm) and the phosphate fines (?0.071 mm). The P2O5 contents of these products reached 12.24%, 28.72% and 18.77%, with P2O5 distribution reached 6.74%, 51.75% and 41.51%, respectively. A global P2O5 of 28.72% was obtained with a recovery of about 52%. A tentative flow-sheet for the whole process was postulated. 相似文献
7.
8.
Steven J. Fliesler Sriganesh Ramachandra Rao Mai N. Nguyen Mahmoud Tawfik KhalafAllah Steven J. Pittler 《International journal of molecular sciences》2022,23(21)
Retinitis pigmentosa-59 (RP59) is a rare, recessive form of RP, caused by mutations in the gene encoding DHDDS (dehydrodolichyl diphosphate synthase). DHDDS forms a heterotetrameric complex with Nogo-B receptor (NgBR; gene NUS1) to form a cis-prenyltransferase (CPT) enzyme complex, which is required for the synthesis of dolichol, which in turn is required for protein N-glycosylation as well as other glycosylation reactions in eukaryotic cells. Herein, we review the published phenotypic characteristics of RP59 models extant, with an emphasis on their ocular phenotypes, based primarily upon knock-in of known RP59-associated DHDDS mutations as well as cell type- and tissue-specific knockout of DHDDS alleles in mice. We also briefly review findings in RP59 patients with retinal disease and other patients with DHDDS mutations causing epilepsy and other neurologic disease. We discuss these findings in the context of addressing “knowledge gaps” in our current understanding of the underlying pathobiology mechanism of RP59, as well as their potential utility for developing therapeutic interventions to block the onset or to dampen the severity or progression of RP59. 相似文献
9.
Ayman Abo Elmaaty Wagdy M. Eldehna Muhammad Khattab Omnia Kutkat Radwan Alnajjar Ahmed N. El-Taweel Sara T. Al-Rashood Mohammed A. S. Abourehab Faizah A. Binjubair Mohamed A. Saleh Amany Belal Ahmed A. Al-Karmalawy 《International journal of molecular sciences》2022,23(20)
In this article, 34 anticoagulant drugs were screened in silico against the main protease (Mpro) of SARS-CoV-2 using molecular docking tools. Idraparinux, fondaparinux, eptifibatide, heparin, and ticagrelor demonstrated the highest binding affinities towards SARS-CoV-2 Mpro. A molecular dynamics study at 200 ns was also carried out for the most promising anticoagulants to provide insights into the dynamic and thermodynamic properties of promising compounds. Moreover, a quantum mechanical study was also conducted which helped us to attest to some of the molecular docking and dynamics findings. A biological evaluation (in vitro) of the most promising compounds was also performed by carrying out the MTT cytotoxicity assay and the crystal violet assay in order to assess inhibitory concentration 50 (IC50). It is worth noting that ticagrelor displayed the highest intrinsic potential for the inhibition of SARS-CoV-2 with an IC50 value of 5.60 µM and a safety index of 25.33. In addition, fondaparinux sodium and dabigatran showed promising inhibitory activities with IC50 values of 8.60 and 9.40 µM, respectively, and demonstrated safety indexes of 17.60 and 15.10, respectively. Moreover, the inhibitory potential of the SARS-CoV-2 Mpro enzyme was investigated by utilizing the SARS-CoV-2 Mpro assay and using tipranavir as a reference standard. Interestingly, promising SARS-CoV-2 Mpro inhibitory potential was attained for fondaparinux sodium with an IC50 value of 2.36 µM, surpassing the reference tipranavir (IC50 = 7.38 µM) by more than three-fold. Furthermore, highly eligible SARS-CoV-2 Mpro inhibitory potential was attained for dabigatran with an IC50 value of 10.59 µM. Finally, an SAR was discussed, counting on the findings of both in vitro and in silico approaches. 相似文献
10.