Influence of Different Additives on the Interaction of Quinolone Antibiotic Drug with Surfactant: Conductivity and Cloud Point Measurement Study

Conductometric and cloud point (CP) measurement studies have been performed to investigate the interaction of tetradecyltrimethylammonium bromide (TTAB) and Triton® X-100 (TX-100) with ciprofloxacin hydrochloride (CFH) in different solvents over the temperature range of 295.15–315.15 K. CFH is used for the treatment of various bacterial infections. The observed critical micelle concentration (CMC) values of TTAB were found to be reduced in the presence of electrolytes (Na₂SO₄/Na₃PO₄), and this reduction proceeds with the elevation of salt concentration. The order of the CMC of TTAB follows the trend: > >. The observed CMC values of TTAB were found to increase with increasing temperature and decrease with increasing concentration of CFH in aqueous medium. The values of Gibbs free energy of micellization () for the TTAB/TTAB + CFH mixture were found to be negative, implying spontaneous micellization. The estimated CP of TX-100 decreases with increasing concentration of TX-100 in aqueous medium. The CP values first decrease with increasing concentration of CFH and then increase at higher concentration of CFH almost in all cases investigated. The values of free energy of clouding were found to be positive in all cases studied implying that phase separation of TX-100 was nonspontaneous. The other thermodynamic parameters associated with the micellization of TTAB and the phase separation of TX-100 were estimated and explained.     

Effect of L-carnitine treatment on very low density lipoprotein kinetics in the hyperlipidemic rabbit

This study examined the hypolipidemic effect of 4 weeks of L-carnitine treatment (170 mg/kg b.w./day) in New Zealand White rabbits fed a high fat diet (5% corn oil/0.5% cholesterol). Specifically, [3H] glycerol and [125I] very low density lipoprotein (VLDL) turnover studies were conducted to examine the effect of treatment on VLDL kinetics. The masses of plasma VLDL-triglycerides (VLDL-TG) and VLDL-apoprotein B (VLDL-apoB) were significantly increased by the high-fat diet. Four weeks of treatment with L-carnitine significantly reduced these masses. Kinetic analysis indicated that fat feeding reduced the fractional catabolic rates (FCRs) of VLDL-TG and VLDL-apoB relative to chow-fed controls. The transport of these VLDL components was not altered by the diet. L-carnitine treatment had no effect on the FCRs of VLDL-TG and VLDL-apoB or on the transport of VLDL-apoB. Yet, treatment significantly lowered the transport of VLDL-TG. These data indicate that the lipid-lowering effect of L-carnitine in this animal model was due, in part, to a decrease in the transport and not due to an alteration in the fractional catabolic rate of VLDL-TG.     

An analysis of fatal bicycle accidents in Victoria (Australia) with a special reference to nighttime accidents

This paper examines the fatal bicycle accidents which occurred in the period 1981-1984 in Victoria with particular emphasis on nighttime fatalities. The examination provides information on aspects of accident location, environment, problem type, time, and cyclist characteristics. The relationship between actual accidents and cyclists perceived collision danger is also investigated. The characteristics of fatal bicycle accidents are different to those of overall "casualty" accidents. A difference also exists between day and night, and between metropolitan and nonmetropolitan fatal accidents. In the metropolitan area, adult cyclists over 17 years were over-involved in fatal accidents. The proportion of cyclists involved in fatalities at night increases with increase in age. Almost 80% of nighttime accidents occurred on links on arterial roads, and the majority in the high speed limit zones (75 kph and over). A greater proportion of accidents was initiated by cyclists. In 90% of nighttime cyclist fatalities the cyclist was hit from the rear, compared with 40% in daytime. Inadequacy of bicycle and street lighting was found to be an important factor in nighttime fatalities.     

Visualizing Extracellular Vesicles and Their Function in 3D Tumor Microenvironment Models

Extracellular vesicles (EVs) are cell-derived nanostructures that mediate intercellular communication by delivering complex signals in normal tissues and cancer. The cellular coordination required for tumor development and maintenance is mediated, in part, through EV transport of molecular cargo to resident and distant cells. Most studies on EV-mediated signaling have been performed in two-dimensional (2D) monolayer cell cultures, largely because of their simplicity and high-throughput screening capacity. Three-dimensional (3D) cell cultures can be used to study cell-to-cell and cell-to-matrix interactions, enabling the study of EV-mediated cellular communication. 3D cultures may best model the role of EVs in formation of the tumor microenvironment (TME) and cancer cell-stromal interactions that sustain tumor growth. In this review, we discuss EV biology in 3D culture correlates of the TME. This includes EV communication between cell types of the TME, differences in EV biogenesis and signaling associated with differing scaffold choices and in scaffold-free 3D cultures and cultivation of the premetastatic niche. An understanding of EV biogenesis and signaling within a 3D TME will improve culture correlates of oncogenesis, enable molecular control of the TME and aid development of drug delivery tools based on EV-mediated signaling.     

Evaluating the Impact of User Characteristics and Different Layouts on an Interactive Visualization for Decision Making

There is increasing evidence that user characteristics can have a significant impact on visualization effectiveness, suggesting that visualizations could be designed to better fit each user's specific needs. Most studies to date, however, have looked at static visualizations. Studies considering interactive visualizations have only looked at a limited number of user characteristics, and consider either low‐level tasks (e.g., value retrieval), or high‐level tasks (in particular: discovery), but not both. This paper contributes to this line of work by looking at the impact of a large set of user characteristics on user performance with interactive visualizations, for both low and high‐level tasks. We focus on interactive visualizations that support decision making, exemplified by a visualization known as Value Charts. We include in the study two versions of ValueCharts that differ in terms of layout, to ascertain whether layout mediates the impact of individual differences and could be considered as a form of personalization. Our key findings are that (i) performance with low and high‐level tasks is affected by different user characteristics, and (ii) users with low visual working memory perform better with a horizontal layout. We discuss how these findings can inform the provision of personalized support to visualization processing.     

Prediction-based energy-efficient target tracking protocol in wireless sensor networks

A prediction based energy-efficient target tracking protocol in wireless sensor networks (PET) was proposed for tracking a mobile target in terms of sensing and communication energy consumption. In order to maximize the lifetime of a wireless sensor network (WSN), the volume of messages and the time for neighbor discovery operations were minimized. The target was followed in a special region known as a face obtained by planarization technique in face-aware routing. An election process was conducted to choose a minimal number of appropriate sensors that are the nearest to the target and a wakeup strategy was proposed to wakeup the appropriate sensors in advance to track the target. In addition, a tracking algorithm to track a target step by step was introduced. Performance analysis and simulation results show that the proposed protocol efficiently tracks a target in WSNs and outperforms some existing protocols of target tracking with energy saving under certain ideal situations.     

DCT statistics-based digital dropout detection in degraded archived media

With the rapid development of visual digital media, the demand for better quality of service has increased the pressure on broadcasters to automate their error detection and restoration activities for preserving their archives. Digital dropout is one of the defects that affect archived visual materials and tends to occur in block by block basis (size of 8 × 8). It is well established that human visual system (HVS) is highly adapted to the statistics of its visual natural environment. Consequently, in this paper, we have formulated digital dropout detection as a classification problem which predicts block label based on statistical features. These statistical features are indicative of perceptual quality relevant to human visual perception, and allow pristine images to be distinguished from distorted ones. Here, the idea is to extract discriminant block statistical features based on discrete cosine transform (DCT) coefficients and determine an optimal neighborhood sampling strategy to enhance the discrimination ability of block representation. Since this spatial frame based approach is free from any motion computation dependency, it works perfectly in the presence of fast moving objects. Experiments are performed on video archives to evaluate the efficacy of the proposed technique.     

Assessing tropical cyclone impacts using object-based moderate spatial resolution image analysis: a case study in Bangladesh

The environmental and societal impacts of tropical cyclones could be reduced using a range of management initiatives. Remote sensing can be a cost effective, accurate, and potential tool for mapping the multiple impacts caused by tropical cyclones using high-to-moderate spatial resolution (5–30 m) satellite imagery to provide data on the following essential parameters – evacuation, relief, and management of natural resources. This study developed and evaluated an approach for assessing the impacts of tropical cyclones through object-based image analysis and moderate spatial resolution imagery. Pre- and post-cyclone maps of artificial and natural features are required for assessing the overall impacts in the landscape that could be acquired by mapping specific land cover types. We used the object-based approach to map land-cover types in pre- and post-cyclone Satellite Pour l’Observation de la Terre (SPOT) 5 image data and the post-classification comparison technique to identify changes in the particular features in the landscape. Cyclone Sidr (2007) was used to test the applicability of this approach in Sarankhola Upazila in Bangladesh. The object-based approach provided accurate results for classifying features from pre- and post-cyclone satellite images with an overall accuracy of 95.43% and 93.27%, respectively. Mapped changes identified the extent, type, and form of cyclone induced impacts. Our results indicate that 63.15% of the study area was significantly affected by cyclone Sidr. The majority of mapped damage was found in vegetation, cropped lands, settlements, and infrastructure. The damage results were verified through the high spatial resolution satellite imagery, reports and pictures that were taken after the cyclone. The methods developed may be used in future to assess the multiple impacts caused by tropical cyclones in Bangladesh and other similar environments for the purposes of tropical cyclone disaster management.     

Domestic Water and Sanitation in Cyclones and Floods in Bangladesh and a Proposed Research Agenda

ABSTRACT

Water is one of the top priority item s i relief activities but the appropriateness and effectiveness of this activity may be questioned. Water and sanitation (WS) are inseparable and together they play major roles in the transmission of the pathogen of diarrhoeal disease. Thousands of people die or suffer from WS-related diseases during postdisaster periods. Here we present WS-related experiences gained after Bangladesh's 1991 cyclone and the views of participants in a regional and a national (local) workshop on this matter held in Bangladesh. About 63 per cent of the water purifying tablets (WPTs) distributed after the 1991 cyclone were found to have lost potency Relief personnel lack basic knowledge about WS practices and the management of WS provision. Participants in the two workshops documented serious problems i this field at both regional and national levels. Major issues for research may include: an appropriate environmental preparedness plan; appropriate waste disposal technologies; appropriate water treatment methods; self- help activities during vulnerable periods; and health education related to WS in disaster situations.