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排序方式: 共有164条查询结果,搜索用时 15 毫秒
1.
Anastasiya Rybak Patrice A. Fokou Michael A. R. Meier 《European Journal of Lipid Science and Technology》2008,110(9):797-804
Olefin metathesis, awarded with the Nobel Prize in Chemistry 2005 for Chauvin, Grubbs and Schrock, has emerged as a powerful tool for organic as well as polymer chemistry. In oleochemistry, this reaction is well known and has been applied for many decades. Examples include the functionalization of the double bonds of different oleochemicals or the (direct) polymerization of plant oils via metathesis. More recent developments, particularly the development of better and more robust catalysts, allow for highly efficient cross‐metathesis reactions opening new possibilities for the direct introduction of chemical functionalities. Within this contribution, the development of metathesis in oleochemistry will be discussed, covering self‐metathesis as well as more recent developments in the field of cross‐metathesis that lead to desired platform chemicals. 相似文献
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An application of data envelopment analysis (DEA) for measuring and evaluating the operating efficiency of power plants in the Israeli Electric Corporation (IEC) is presented. Emphasis is placed on the process of screening the list of potential input and output factors and determining the most relevant ones. Special attention is given to the qualitative factor concerning air pollution, which is treated as a categorical variable. The incorporation of `standard data' is examined and the results are analyzed 相似文献
4.
DL Newton S Walbridge SM Mikulski W Ardelt K Shogen SJ Ackerman SM Rybak RJ Youle 《Canadian Metallurgical Quarterly》1994,14(2):538-544
Purkinje cell toxicity is one of the characteristic features of the Gordon phenomenon, a syndrome manifested by ataxia, muscular rigidity, paralysis, and tremor that may lead to death (Gordon, 1933). Two members of the RNase superfamily found in humans, EDN (eosinophil-derived neurotoxin) and ECP (eosinophil cationic protein), cause the Gordon phenomenon when injected intraventricularly into guinea pigs or rabbits. We have found that another member of the RNase superfamily, an antitumor protein called onconase, isolated from Rana pipiens oocytes and early embryos, will also cause the Gordon phenomenon when injected into the cerebrospinal fluid of guinea pigs at a dose similar to that of EDN (LD50, 3-4 micrograms). Neurologic abnormalities of onconase-treated animals were indistinguishable from those of EDN-treated animals, and histology showed dramatic Purkinje cell loss in the brains of onconase-treated animals. The neurotoxic activity of onconase correlates with ribonuclease activity. Onconase modified by iodoacetic acid to eliminate 70% and 98% of the ribonuclease activity of the native enzyme displays a similar decrease in ability to cause the Gordon phenomenon. In contrast, the homologous bovine pancreatic RNase A injected intraventricularly at a dose 5000 times greater than the LD50 dose of EDN or onconase is not toxic and does not cause the Gordon phenomenon. A comparison of the RNase activities of EDN, onconase, and bovine pancreatic RNase A using three pancreatic RNA substrates demonstrates that onconase is orders of magnitude less active enzymatically than EDN and RNase A. Thus, another member of the RNase superfamily in addition to EDN and ECP can cause the Gordon phenomenon.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
5.
Nadezhda A. Evtushenko Arkadii K. Beilin Erdem B. Dashinimaev Rustam H. Ziganshin Anastasiya V. Kosykh Maxim M. Perfilov Alexandra L. Rippa Elena V. Alpeeva Andrey V. Vasiliev Ekaterina A. Vorotelyak Nadya G. Gurskaya 《International journal of molecular sciences》2021,22(8)
The recessive form of dystrophic epidermolysis bullosa (RDEB) is a crippling disease caused by impairments in the junctions of the dermis and the basement membrane of the epidermis. Using ectopic expression of hTERT/hTERT + BMI-1 in primary cells, we developed expansible cultures of RDEB fibroblasts and keratinocytes. We showed that they display the properties of their founders, including morphology, contraction ability and expression of the respective specific markers including reduced secretion of type VII collagen (C7). The immortalized keratinocytes retained normal stratification in 3D skin equivalents. The comparison of secreted protein patterns from immortalized RDEB and healthy keratinocytes revealed the differences in the contents of the extracellular matrix that were earlier observed specifically for RDEB. We demonstrated the possibility to reverse the genotype of immortalized cells to the state closer to the progenitors by the Cre-dependent hTERT switch off. Increased β-galactosidase activity and reduced proliferation of fibroblasts were shown after splitting out of transgenes. We anticipate our cell lines to be tractable models for studying RDEB from the level of single-cell changes to the evaluation of 3D skin equivalents. Our approach permits the creation of standardized and expandable models of RDEB that can be compared with the models based on primary cell cultures. 相似文献
6.
Craig K. Docherty Anastasiya Strembitska Christa P. Baker Fiona F. Schmidt Kieran Reay John R. Mercer 《International journal of molecular sciences》2022,23(1)
The cardiovascular disease of atherosclerosis is characterised by aged vascular smooth muscle cells and compromised cell survival. Analysis of human and murine plaques highlights markers of DNA damage such as p53, Ataxia telangiectasia mutated (ATM), and defects in mitochondrial oxidative metabolism as significant observations. The antiageing protein Klotho could prolong VSMC survival in the atherosclerotic plaque and delay the consequences of plaque rupture by improving VSMC phenotype to delay heart attacks and stroke. Comparing wild-type VSMCs from an ApoE model of atherosclerosis with a flox’d Pink1 knockout of inducible mitochondrial dysfunction we show WT Pink1 is essential for normal cell viability, while Klotho mediates energetic switching which may preserve cell survival. Methods: Wild-type ApoE VSMCs were screened to identify potential drug candidates that could improve longevity without inducing cytotoxicity. The central regulator of cell metabolism AMP Kinase was used as a readout of energy homeostasis. Functional energetic switching between oxidative and glycolytic metabolism was assessed using XF24 technology. Live cell imaging was then used as a functional readout for the WT drug response, compared with Pink1 (phosphatase-and-tensin-homolog (PTEN)-induced kinase-1) knockout cells. Results: Candidate drugs were assessed to induce pACC, pAMPK, and pLKB1 before selecting Klotho for its improved ability to perform energetic switching. Klotho mediated an inverse dose-dependent effect and was able to switch between oxidative and glycolytic metabolism. Klotho mediated improved glycolytic energetics in wild-type cells which were not present in Pink1 knockout cells that model mitochondrial dysfunction. Klotho improved WT cell survival and migration, increasing proliferation and decreasing necrosis independent of effects on apoptosis. Conclusions: Klotho plays an important role in VSMC energetics which requires Pink1 to mediate energetic switching between oxidative and glycolytic metabolism. Klotho improved VSMC phenotype and, if targeted to the plaque early in the disease, could be a useful strategy to delay the effects of plaque ageing and improve VSMC survival. 相似文献
7.
E. V. Gaponenko L. A. Rybak L. G. Virabyan 《Journal of Machinery Manufacture and Reliability》2020,49(1):16-23
This paper considers a method of determining the stiffness and displacement of the output link of a tripod robot that is a part of a robotic system with relative manipulation modules based on a Jacobian matrix. It shows that the stiffness maps reveal the maximum and minimum stiffness in the robot workspace. An algorithm for calculating the error caused by the displacement of the output link under the action of the cutting force is given. The modeling results are presented. 相似文献
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9.
Anastasiya N. Mikhailova Galina P. Kayukova Igor P. Kosachev Irina I. Vandyukova Alexey V. Vakhin Georgy A. Batalin 《Petroleum Science and Technology》2018,36(17):1382-1388
Character of conversion of organic matter from Domanic rocks of Pervomaiskoye field (Tatarstan) of Semiluki horizon of upper Devonian deposits in the hydrothermal-catalytic system at temperature of 300?°C in carbon dioxide medium was studied with the application of complex of oil-soluble precursors of catalysts containing Fe, Co, and Cu. In presence of catalysts complex, content of organic extract increases, in which content of hydrocarbon fractions, saturated and aromatic hydrocarbons, increases 1.5 times, while resins content decreases by two times. As result of kerogen destruction in products of experiments, the content of asphaltenes and carbonaceous substances such as carbenes and carboides increase. 相似文献
10.
M. Rybak 《Materials and Structures》1983,16(1):13-17
Résumé L'application du collage au renforcement des ponts en béton armé et béton précontraint en cas d'insuffisance de l'armature
semble être, dans certains cas, très économique et utile. On a appliqué le collage à ce système de renforcement pour la reconstruction
de quelques ponts en Pologne. On présente trois cas dans cet article.
Summary Application of gluing of reinforcing steel to the surfaces of concrete structures seems to be one of the most economic and practical system of strengthening reinforced and prestressed concrete bridges. This method can be applied in many cases of insufficient reinforcing steel in reconstructed bridges. Epoxy resins ensure glued joints with sufficient strength and long term resistance. This system of strengthening has been applied to reconstruct several bridges in Poland. Three examples are described in this paper. In one of these bridges the gluing of reinforcing steel was performed in the upper surfaces of Gerber-plate bridge concrete in negative bending moment areas. The flat steel strips, well cleaned and protected against corrosion, were glued to the specially prepared surface concrete. The other repair work consisted in gluing the flat iron strips on the lower surface of the concrete bridge plate. In this case, high strength bolts were used to fasten the ends of the steel bands to the bridge slab. All the work of strengthening was performed during the winter at low temperatures, from 0 to −20°C. Equally extensive strengthening work with the aid of gluing was performed during adaptation to new loads of the old concrete viaducs in the area of Central Railway Station in Warsaw. Here the steel strips and the additional reinforcing steel were glued to the side surface of the concrete slabs. Anchoring bolts were used in all cases. This method of gluing flat steel strips to strengthen insufficiently reinforced concrete bridges is very simple and economic compared with others.相似文献