Constant thrust programming for a multistage rocket flown in vacuum with a given initial/final thrust-to-weight ratio in an arbitrary stage

The burn time and burnout velocity of a multistage rocket flown vertically in vacuum with constant thrust tangential to the flight path and a prescribed initial/final thrust-to-weight ratio in an arbitrary stage have been determined. The present paper also deals with optimal staging under given conditions of flight.     

Numerical models of creep and boundary sliding mechanisms in single-phase, dual-phase, and fully lamellar titanium aluminide

Finite element simulations of the high-temperature behavior of single-phase γ, dual-phase α₂+γ, and fully lamellar (FL) α₂+γTiAl intermetallic alloy microstructures have been performed. Nonlinear viscous primary creep deformation is modeled in each phase based on published creep data. Models were also developed that incorporate grain boundary and lath boundary sliding in addition to the dislocation creep flow within each phase. Overall strain rates are compared to gain an understanding of the relative influence each of these localized deformation mechanisms has on the creep strength of the microstructures considered. Facet stress enhancement factors were also determined for the transverse grain facets in each model to examine the relative susceptibility to creep damage. The results indicate that a mechanism for unrestricted sliding of γ lath boundaries theorized by Hazzledine and co-workers leads to unrealistically high strain rates. However, the results also suggest that the greater creep strength observed experimentally for the lamellar microstructure is primarily due to inhibited former grain boundary sliding (GBS) in this microstructure compared to relatively unimpeded GBS in the equiaxed microstructures. The serrated nature of the former grain boundaries generally observed for lamellar TiAl alloys is consistent with this finding.     

An automated, parallel processing approach to biomolecular sample preparation

Sample preparation for DNA and RNA assays is a prime candidate for laboratory automation. A novel, parallel processing device that performs the three separate liquid-handling functions necessary for such sample preparation-dispensing, pipetting, and pressurizing-is presented. The device comprises an array of fine nozzles connected by fluidic channels to automatically and precisely distribute flow between one source and an array of points. The design principles, as well as the experimental and computational methods used to develop the device, are described. Test results, including accuracy, uniformity, volume range, and timing, are presented. The functionality of the device is demonstrated by performing a solid-phase extraction of DNA with two types of microcolumns.     

An Experimental Study to Evaluate the Effect of Ambient Temperature during Manual Lifting and Design of Optimal Task Parameters

In the present study, the effect of lifting task parameters on the heart rate and oxygen uptake of workers during manual lifting tasks in different ambient conditions was evaluated. The experiments conducted in two different temperature conditions showed a significantly higher oxygen uptake and heart rate in colder conditions as compared to warmer conditions. Three other factors, namely, load, lifting frequency, and vertical distance were found to significant affect the responses. Various combinations of significant factors were used to calculate oxygen uptake and heart rate. These were then compared with the safe limits as per the maximum aerobic capacity of workers. Based on these comparisons, the safe combinations were identified that can be used to design lifting tasks in varied ambient conditions. The study further concluded that lifting tasks performed in winter should have different relaxation or fatigue allowances built into the cycle time of the task to compensate for higher exertion. © 2011 Wiley Periodicals, Inc.     

Structure-property relations for a phase-pure,nanograined tetragonal zirconia ceramic stabilized with minimum CaO doping

Dense (~97%) CaO-stabilized ZrO₂ ceramic was stabilized with minimum (3 mol%) doping (reported to date) and processed via conventional sintering at a low temperature (~1200°C); compositional analysis via X-ray florescence confirmed the CaO doping accuracy. Phase-pure tetragonal structure (characterized via both X-ray diffraction and Raman spectroscopy) along with uniform nanograins (90 nm) of the ceramic ensured the evolution of no monoclinic phase even after vigorous low-temperature degradation experiments (both thermal and hydrothermal aging for 80-100 h). The sintered ceramic recorded a high hardness (~15 GPa); the indentation toughness value was also comparable to a 3 mol% yttria-stabilized zirconia system. The remarkable structure–property correlations in the 3 mol% CaO-stabilized ZrO₂ ceramic suggests that the same may be worth examining for suitable future applications (e.g., in dental ceramics).     

Design and implementation of a block‐backstepping based tracking control for nonholonomic wheeled mobile robot

This paper presents formulation of a novel block‐backstepping based control algorithm to overcome the challenges posed by the tracking and the stabilization problem for a differential drive wheeled mobile robot (WMR). At first, a two‐dimensional output vector for the WMR has been defined in such a manner that it would decouple the two control inputs and, thereby, allow the designer to formulate the control laws for the two inputs one at a time. Actually, the decoupling has been carried out in a way to convert the system into block‐strict feedback form. Thereafter, block‐backstepping control algorithm has been utilized to derive the expressions of the control inputs for the WMR system. The proposed block‐backstepping technique has further been enriched by incorporating an integral action for enhancing the steady state performance of the overall system. Global asymptotic stability of the overall system has been analyzed using Lyapunov stability criteria. Finally, the proposed control algorithm has been implemented on a laboratory scale differential drive WMR to verify the effectiveness of the proposed control law in real‐time environment. Indeed, the proposed design approach is novel in the sense that it has judiciously exploited the nonholonomic constraint of the WMR to result in a reduced order block‐backstepping controller for the WMR, and thereby, it has eventually yielded a compact expression of the control law that is amenable to real‐time implementation. Copyright © 2015 John Wiley & Sons, Ltd.     

A Formal Methodology for Detecting Managerial Vulnerabilities and Threats in an Enterprise Information System

From information security point of view, an enterprise is considered as a collection of assets and their interrelationships. These interrelationships may be built into the enterprise information infrastructure, as in the case of connection of hardware elements in network architecture, or in the installation of software or in the information assets. As a result, access to one element may enable access to another if they are connected. An enterprise may specify conditions on the access of certain assets in certain mode (read, write etc.) as policies. The interconnection of assets, along with specified policies, may lead to managerial vulnerabilities in the enterprise information system. These vulnerabilities, if exploited by threats, may cause disruption to the normal functioning of information systems. This paper presents a formal methodology for detection of managerial vulnerabilities of, and threats to, enterprise information systems in linear time.     

Multi‐response optimization and empirical modeling of cardiopulmonary responses during manual lifting tasks

An experimental study involving five independent lifting variables (namely weight, lift frequency, horizontal distance from the object, operator, and vertical distance) and their interactions was conducted using the Taguchi L₂₇ design. Two responses—heart rate and oxygen uptake—were measured during each trial. To optimize both responses simultaneously, the signal‐to‐noise ratio was normalized to obtain a multi‐response signal‐to‐noise (MRSN) ratio for each trial. The MRSN ratio was analyzed using analysis of variance to identify the optimal condition in which both responses were optimized at the same time. Lift frequency was found to be the most significant factor, and operator and horizontal distance were found to be least significant. The empirical modeling equation was developed and can be used to predict the response values during experimental trials involving similar work conditions. © 2010 Wiley Periodicals, Inc.     

Simulated annealing based automatic fuzzy clustering combined with ANN classification for analyzing microarray data

Microarray technology has made it possible to monitor the expression levels of many genes simultaneously across a number of experimental conditions. Fuzzy clustering is an important tool for analyzing microarray gene expression data. In this article, a real-coded Simulated Annealing (VSA) based fuzzy clustering method with variable length configuration is developed and combined with popular Artificial Neural Network (ANN) based classifier. The idea is to refine the clustering produced by VSA using ANN classifier to obtain improved clustering performance. The proposed technique is used to cluster three publicly available real life microarray data sets. The superior performance of the proposed technique has been demonstrated by comparing with some widely used existing clustering algorithms. Also statistical significance test has been conducted to establish the statistical significance of the superior performance of the proposed clustering algorithm. Finally biological relevance of the clustering solutions are established.