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排序方式: 共有261条查询结果,搜索用时 15 毫秒
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Elena Crespi Antonio Capolongo Davide Fissore Antonello A. Barresi 《Drying Technology》2008,26(3):349-356
The aim of this article is to develop an experiment and a procedure to investigate the restoration of water-damaged paper and archival materials using freeze drying in order to allow a reproducible test and comparison of the influence of different operating conditions on drying time and restored paper quality. Firstly, a reproducible method for the preparation of soaked samples simulating water-damaged paper has been developed. Then, the samples have been freeze-dried in a laboratory-scale apparatus that allowed monitoring the temperature as well as the weight of the samples. The technique of evaporative freezing, which reduces the drying time required, has been used in this case. An innovative procedure for the visualization of the progress of the drying process has been validated, thus allowing the validation of a simple phenomenological model of the time evolution of the ice core volume; in addition, data on the residual moisture of the dried paper sheets in different zones have been given. Finally, optimization of this particular drying process by using simple or more sophisticated approaches has been discussed. 相似文献
3.
José Augusto de Oliveira Diogo Aparecido Lopes Silva Mariana Guardia Lillian do Nascimento Gambi Otávio José de Oliveira Aldo Roberto Ometto 《Clean Technologies and Environmental Policy》2017,19(6):1761-1774
The companies’ needs to adopt changes in their way of production to maximize the environmental performance required by their stakeholders, and at the same time, to maximize their economic and market performance, have made them seek for environmental strategies and certifications. In this sense, the Cleaner Production and the Environmental Management System based on ISO 14001 have been, respectively, presented, since the main objective of this research is to identify and analyze Cleaner Production contributions to comply with ISO 14001 requirements. For such, a survey research has been carried out in Brazilian industrial companies certified by ISO 14001. We have identified the main performance factors by leading practices and variables of Cleaner Production that contribute to the compliance with the standard requirements by companies. Thus, it has been noted that Cleaner Production is an important strategy for the preparation of companies for certification as well as for improving their environmental performance. 相似文献
4.
Colussi C Banfi C Brioschi M Tremoli E Straino S Spallotta F Mai A Rotili D Capogrossi MC Gaetano C 《Proteomics. Clinical applications》2010,4(1):71-83
Purpose: Histone Deacetylase Inhibitors (DI) ameliorates dystrophic muscle regeneration restoring muscular strength in the mdx mouse model of Duchenne muscular dystrophy (DMD). The further development of these compounds as drugs for DMD treatment is currently hampered by the lack of knowledge about DIs effect in large dystrophic animal models and that of suitable biomarkers to monitor their efficacy. Experimental design: In this study we applied proteomic analysis to identify differentially expressed proteins present in plasma samples from mdx mice treated with the Suberoylanilide hydroxamic acid (SAHA) and relative normal controls (WT). Results: Several differentially expressed proteins were identified between untreated wild type and mdx mice. Among these, fibrinogen, epidermal growth factor 2 receptor, major urinary protein and glutathione peroxidase 3 (GPX3) were constitutively up‐regulated in mdx, while complement C3, complement C6, gelsolin, leukaemia inhibitory factor receptor (LIFr), and alpha 2 macroglobulin were down‐regulated compared to WT mice. SAHA determined the normalization of LIFr and GPX3 protein level while apoliprotein E was de novo up‐regulated in comparison to vehicle‐treated mdx mice. Conclusions and clinical relevance: Collectively, these data unravel potential serological disease biomarkers of mdx that could be useful to monitor muscular dystrophy response to DI treatment. 相似文献
5.
Rafael Antonello Stênio Fernandes Josilene Moreira Paulo Cunha Carlos Kamienski Djamel Sadok 《Multimedia Systems》2009,15(1):33-47
Virtual Worlds (VW), such as Massive Multiplayer Online Social Games, have been gaining increasing attention in the last few
years, mainly due to the new way users interact with them. However, little effort has been devoted to understand their traffic
profile and the implications to the traffic management area. With the current growing rate of VWs’ usage, their traffic demand
could eventually impose a significant burden on the operation of a typical Internet Service Provider (ISP) network. In this
paper, we seek to understand the traffic behavior of an increasingly popular VW application, namely Second Life (SL), from
both the connection and network level perspectives. We also show results of a traffic analysis of a SL client, when an avatar
performs different actions in the VW, at different places and under different network conditions. Our results show that SL
makes intensive use of network resources (mostly bandwidth), since the capacity needed for having a full SL experience (listening
to live music) may reach 500 kbps. We then extend the traffic analysis work on SL by providing analytical models for its traffic
profile. We aim at helping the network management and planning area to estimate the impact of an intense use of such VW on
access links or core networks. Such synthetic models are also useful to the networking research community for the use in network
simulations. 相似文献
6.
Guglielmo Barone Antonello d’Alessandro Guido de Blasio 《Papers in Regional Science》2019,98(5):1893-1902
National policies may have heterogeneous effects at the regional level. When coming to programmes aimed at increasing human capital, worker mobility from poorer to richer regions can reduce the benefits of the policy for the former areas. We focus on Italy and estimate the impact of education on the probability of migrating from a lagging area to a leading one. Endogeneity is addressed by exploiting an increase in the minimum school-leaving age in an instrumental variable framework. We find that one additional year of education increases the probability to migrate by 1.7 percentage points (9% of the average migration rate). 相似文献
7.
Monica Rosa Loizzo Marco Bonesi Annalisa Serio Clemencia Chaves-López Tiziana Falco Antonello Paparella 《International Journal of Food Properties》2017,20(4):899-910
Capsicum annum cultivars Yellow cayenne, Portafortuna, Idealino, Sole, Duemila, Pellegrino, Fantasia, Loco, and Effix were investigated for their antioxidant properties and foodborne pathogens inhibitory activity. The total phenols, flavonoids, anthocyanins, capsaicinoids, carotenoids, ascorbic acid, and vitamin E content were also determined. Duemila and Portafortuna cultivars showed the highest total phenol content with values of 924.3 and 935.0 mg of chlorogenic acid equivalents/100 g dried weight, respectively. Idealino pepper presented the highest capsaicin content (2932.1 μg/g dried weight). The antioxidant capacity was evaluated by using 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid test, 2,2-diphenyl-1-picrylhydrazyl test, and ferric reducing ability power assay. Both Pellegrino and Idealino samples exhibited a promising radical scavenging ability against 2,2’-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid radical with IC50 values of 45.2 and 45.7 μg/mL, respectively. All the extracts were able to inhibit the growth of Staphylococcus aureus and Listeria monocytogenes investigated strains. The most active are Effix and Fantasia peppers with minimal inhibitory concentration between 12.5 and 25.0 mg/mL, respectively. Overall, these results support the use of these pepper species as dried extract in food preservation. 相似文献
8.
Antonello A. Barresi Marco Cittadini 《The International journal of environmental studies》2013,70(2):179-188
By‐products formation in the catalytic combustion of different aromatic compounds has been experimentally investigated. A commercial Pt‐based catalyst, in the shape of a short monolith, has been employed. Toluene, styrene, o‐xylene and cumene have been tested at low concentrations for conversions in the range 5–50%. The results confirm the formation of benzene in the combustion of toluene and styrene, as previously observed by other researchers, but in a very small amount; testing cumene, significant amounts of acetone have been found in the outlet flow. Some hypothesis about the reaction mechanism are put forward. 相似文献
9.
N‐Benzyl‐4‐((heteroaryl)methyl)benzamides: A New Class of Direct NADH‐Dependent 2‐trans Enoyl–Acyl Carrier Protein Reductase (InhA) Inhibitors with Antitubercular Activity
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Ana Guardia Dr. Gulcin Gulten Dr. Raquel Fernandez Jesus Gómez Dr. Feng Wang Dr. Maire Convery Delia Blanco María Martínez Dr. Esther Pérez‐Herrán Marta Alonso Dr. Fátima Ortega Dr. Joaquín Rullás Dr. David Calvo Lydia Mata Dr. Robert Young Prof. James C. Sacchettini Dr. Alfonso Mendoza‐Losana Dr. Modesto Remuiñán Dr. Lluís Ballell Pages Dr. Julia Castro‐Pichel 《ChemMedChem》2016,11(7):687-701
Isoniazid (INH) remains one of the cornerstones of antitubercular chemotherapy for drug‐sensitive strains of M. tuberculosis bacteria. However, the increasing prevalence of multidrug‐resistant (MDR) and extensively drug‐resistant (XDR) strains containing mutations in the KatG enzyme, which is responsible for the activation of INH into its antitubercular form, have rendered this drug of little or no use in many cases of drug‐resistant tuberculosis. Presented herein is a novel family of antitubercular direct NADH‐dependent 2‐trans enoyl–acyl carrier protein reductase (InhA) inhibitors based on an N‐benzyl‐4‐((heteroaryl)methyl)benzamide template; unlike INH, these do not require prior activation by KatG. Given their direct InhA target engagement, these compounds should be able to circumvent KatG‐related resistance in the clinic. The lead molecules were shown to be potent inhibitors of InhA and showed activity against M. tuberculosis bacteria. This new family of inhibitors was found to be chemically tractable, as exemplified by the facile synthesis of analogues and the establishment of structure–activity relationships. Furthermore, a co‐crystal structure of the initial hit with the enzyme is disclosed, providing valuable information toward the design of new InhA inhibitors for the treatment of MDR/XDR tuberculosis. 相似文献
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