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1.
Poly(ADP-ribose) polymerases (PARP) are proteins responsible for DNA damage detection and signal transduction. PARP inhibitors (PARPi) are able to interact with the binding site for PARP cofactor (NAD+) and trapping PARP on the DNA. In this way, they inhibit single-strand DNA damage repair. These drugs have been approved in recent years for the treatment of ovarian cancer. Although they share some similarities, from the point of view of the chemical structure and pharmacodynamic, pharmacokinetic properties, these drugs also have some substantial differences. These differences may underlie the different safety profiles and activity of PARPi.  相似文献   
2.
The LHC insertions will be equipped with individually powered MQM superconducting quadrupoles, produced in three versions with magnetic lengths of 2.4 m, 3.4 m, and 4.8 m. The quadrupoles feature a 56 mm aperture coil, designed on the basis of an 8.8 mm wide Rutherford-type NbTi cable for a nominal gradient of 200 T/m at 1.9 K and 5390 A. A total of 96 quadrupoles are in production in Tesla Engineering, UK. In this report we describe the construction of the pre-series MQM quadrupoles and present the results of the qualification tests.  相似文献   
3.
Synergism between recombinant human tumour necrosis factor (rHuTNF) and DNA topoisomerase II inhibitor VP16 during the killing of cells has been studied in six human ovarian cancer cell lines (A2774, A2780, SW626, IGROV-1, SKOV3, Pa1) and a cervical carcinoma cell line (Me180). Studies were performed using an assay of colony formation inhibition (drug treatment for 1 h) and a growth inhibition assay (continuous exposure for 20 h). Concomitant treatment of cells with VP16+rHuTNF enhanced cell killing in all the cell lines tested--an effect observed in both short- and long-term cytotoxicity assays. This study suggests that the activity of VP16 in ovarian cancer cell lines might be enhanced by rHuTNF in in vitro models.  相似文献   
4.
In this article the direct boundary element formulations of stretching and bending plate problems are combined together to solve thin walled structures and other similar frames. The final system is obtained by assuming each individual plane structural element as a subregion. After the necessary transforms of these equations they can be combined together taking into account the displacement compatibility and equilibrium conditions.  相似文献   
5.
New ternary stannides are reported: RE1+xRh2Sn4?x, 0 ? x ? 0,5 (RE = La ? Sm). NdRh2Sn4 has been characterized by single - crystal X-ray diffraction analysis. Its structure is of a new type with space group Pnma and Z = 4: a = 18,535(3), b = 4,463(1), c = 7,229(1)A?, Dx = 9,16 g.cm?1, μ(AgKα) = 13,6 mm?1, F(000) = 1300, R = 0,040 for 496 independent reflexions (Rw = 0,047). One of the tin sites can be partly occupied by rare earths atoms. The structure types of NdRh2Sn4 and Y2Rh3Sn5 are closely related. LaRh2Sn4 does not exhibit superconductivity above 1.4 K.  相似文献   
6.
7.
Neural Computing and Applications - In this paper, we present the novel Deep-MEG approach in which image-based representations of magnetoencephalography (MEG) data are combined with ensemble...  相似文献   
8.
The magnetic properties of ThCr2Si2-type structure CaMn2Ge2 and BaMn2Ge2 compounds have been investigated by neutron diffraction experiments. In the whole temperature range studied (2–270 K), both compounds are purely collinear antiferromagnets (not detected by bulk magnetometric measurements) characterized by a stacking of antiferromagnetic (001) Mn planes. This peculiar Mn-sublattice magnetic behaviour seems to be related to the valency of the large metal. At 2 K, the total Mn moments are about 2.7 μB and 3.6 μB for CaMn2Ge2 and BaMn2Ge2, respectively. The results are compared with those of closely related RMnSi and RMnGe compounds and the isotypic alkali-metal manganese pnictides. The magnetic properties of the ThCr2Si2-type structure RMn2X2 (XSi, Ge) compounds are discussed.  相似文献   
9.
Investigations made by powder X-ray diffraction, susceptibility measurements and neutron diffraction experiments on the ternary silicide TbMnSi are reported. This compound crystallizes in the tetragonal structure of the CeFeSi-type (space group, P4/nmm). It exhibits a ferrimagnetic behaviour below Tc = 260 K. The magnetization value and the coercive field are 2.7 μB and 6 kOe, respectively, at 4.2 K. Neutron diffraction study confirms that both Mn and Tb sublattices order simultaneously at 260 K. The magnetic structure consists of Mn and Tb ferromagnetic (001) layers coupled antiferromagnetically (μMn = 2.2 μB and μTb = 8.45 μB at 2 K). The occurrence of a ferromagnetic Mn(001) layer in this CeFeSi-type structure compound is discussed.  相似文献   
10.
A molecular distillation plant, built particularly to increase the separation efficiency and to obtain safer working conditions, was tested to remove cholesterol from anhydrous butter and lard. A preliminary experiment was carried out with butter to evaluate the fractionation obtained at temperatures between 190 and 250°C and residual pressures between 10−3 and 10−4 torr. A second experiment was carried out at 185°C and at the maximum operational vacuum, evaluating the fractionation achieved within a time scale between 30 and 180 min. Cholesterol was almost completely removed during the second hour with minimal loss of low-molecular weight triglycerides. An experiment was carried out with lard at 250°C and maximum achievable operational vacuum (10−4 Torr), lasting approximately 6 h, and cholesterol was removed almost completely during the second hour without significant modifications in the triglyceride composition. This situation remained constant throughout the duration of the test.  相似文献   
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