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Aristea-Maria Papanota Paraskevi Karousi Christos K. Kontos Ioannis Ntanasis-Stathopoulos Andreas Scorilas Evangelos Terpos 《International journal of molecular sciences》2021,22(5)
Multiple myeloma (MM) is a common hematological malignancy arising from terminally differentiated plasma cells. In the majority of cases, symptomatic disease is characterized by the presence of bone disease. Multiple myeloma bone disease (MMBD) is a result of an imbalance in the bone-remodeling process that leads to increased osteoclast activity and decreased osteoblast activity. The molecular background of MMBD appears intriguingly complex, as several signaling pathways and cell-to-cell interactions are implicated in the pathophysiology of MMBD. MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate the expression of their target mRNAs. Numerous miRNAs have been witnessed to be involved in cancer and hematological malignancies and their role has been characterized either as oncogenic or oncosuppressive. Recently, scientific research turned towards miRNAs as regulators of MMBD. Scientific data support that miRNAs finely regulate the majority of the signaling pathways implicated in MMBD. In this review, we provide concise information regarding the molecular pathways with a significant role in MMBD and the miRNAs implicated in their regulation. Moreover, we discuss their utility as molecular biomarkers and highlight the putative usage of miRNAs as novel molecular targets for targeted therapy in MMBD. 相似文献
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Aristea-Maria Papanota Paraskevi Karousi Christos K. Kontos Pinelopi I. Artemaki Christine-Ivy Liacos Maria-Alexandra Papadimitriou Tina Bagratuni Evangelos Eleutherakis-Papaiakovou Panagiotis Malandrakis Ioannis Ntanasis-Stathopoulos Maria Gavriatopoulou Efstathios Kastritis Margaritis Avgeris Meletios-Athanasios Dimopoulos Andreas Scorilas Evangelos Terpos 《International journal of molecular sciences》2021,22(23)
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