Extracellular Environment-Controlled Angiogenesis,and Potential Application for Peripheral Nerve Regeneration

Endothelial cells acquire different phenotypes to establish functional vascular networks. Vascular endothelial growth factor (VEGF) signaling induces endothelial proliferation, migration, and survival to regulate vascular development, which leads to the construction of a vascular plexuses with a regular morphology. The spatiotemporal localization of angiogenic factors and the extracellular matrix play fundamental roles in ensuring the proper regulation of angiogenesis. This review article highlights how and what kinds of extracellular environmental molecules regulate angiogenesis. Close interactions between the vascular and neural systems involve shared molecular mechanisms to coordinate developmental and regenerative processes. This review article focuses on current knowledge about the roles of angiogenesis in peripheral nerve regeneration and the latest therapeutic strategies for the treatment of peripheral nerve injury.     

Validation of micro-fusion chromatographic analysis of polyester systems

An examination of parameters for the use of a micro reactor for alkali fusion as a preliminary to chromatographic analysis is described. The reactor allows the use of small, i.e. 2–5 mg, samples comparable with those used with an in situ reactor constructed from a furnace pyrolyser. The use of the reactor is demonstrated by the analyses of several polyester samples.