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1.
Dystrophin is a plasma membrane-associated cytoskeletal protein of the spectrin superfamily. The dystrophin cytoskeleton has been first characterized in muscle. Muscular 427 kDa dystrophin binds to subplasmalemmal actin filaments via its amino-terminal domain. The carboxy-terminus of dystrophin binds to a plasma membrane anchor, beta-dystroglycan, which is associated on the external side with the extracellular matrix receptor, alpha-dystroglycan, that binds to the basal lamina proteins laminin-1, laminin-2, and agrin. In the muscle, the dystroglycan complex is associated with the sarcoglycan complex that consists of several glycosylated, integral membrane proteins. The absence or functional deficiency of the dystrophin cytoskeleton is the cause of several types of muscular dystrophies including the lethal Duchenne muscular dystrophy (DMD), one of the most severe and most common genetic disorders of man. The dystrophin complex is believed to stabilize the plasma membrane during cycles of contraction and relaxation. Muscular dystrophin and several types of dystrophin variants are also present in extramuscular tissues, e.g. in distinct regions of the central nervous systems including the retina. Absence of dystrophin from these sites is believed to be responsible for some extramuscular symptoms of DMD, e.g. mental retardation and disturbances in retinal electrophysiology (reduced b-wave in electroretinograms). The reduced b-wave in electroretinograms indicated a disturbance of neurotransmission between photoreceptors and ON-bipolar cells. At least two different dystrophin variants are present in photoreceptor synaptic complexes. One of these dystrophins (Dp260) is virtually exclusively expressed in the retina. In the neuroretina, dystrophin is found in significant amounts in the invaginated photoreceptor synaptic complexes. At this location dystrophin colocalizes with dystroglycan. Agrin, an extracellular ligand of alpha-dystroglycan, is also present at this location whereas the proteins of the sarcoglycan complex appear to be absent in photoreceptor synaptic complexes. Dystrophin and dystroglycan are located distal from the ribbon-containing active synaptic zones where both proteins are restricted to the photoreceptor plasma membrane bordering on the lateral sides of the synaptic invagination. In addition, some neuronal profiles of the postsynaptic complex also contain dystrophin and beta-dystroglycan. These profiles appear to belong at least in part to projections of the photoreceptor terminals into the postsynaptic dendritic complex. In view of the abnormal neurotransmission between photoreceptors and ON-bipolar cells in DMD patients the dystrophin/beta-dystroglycan-containing projections of photoreceptor presynaptic terminals into the postsynaptic dendritic plexus might somehow modify the ON-bipolar pathway. Another retinal site associated with dystrophin/beta-dystropglycan is the plasma membrane of Müller cells where dystrophin/beta-dystroglycan appear to be present at particular high concentrations. At this location the dystrophin/dystroglycan complex may play a role in the attachment of the retina to the vitreous, and, under pathological conditions, in traction-induced retinal detachment. 相似文献
2.
S.K. Marik D.V.H. Rao A. Bhatnagar R.C. Pant A.C. Tikku S. Sankar 《Nuclear Engineering and Design》2006,236(7-8):730-746
Cirus, a 40 MW t, vertical tank type research reactor, having wide range of research facilities, was commissioned in the year 1960. This research reactor, situated at Mumbai, India has been operated and utilized extensively for isotope production, material testing and neutron beam research for nearly four decades. With a view to assess the residual life of the reactor, detailed ageing studies were carried out during the early 1990s. Based on these studies, refurbishment of Cirus for its life extension was taken up. During refurbishment, additional safety features were incorporated in various systems to qualify them for the current safety standards. This paper gives the details of the operating experiences, utilization of the reactor along with methodologies followed for carrying out detailed ageing studies, refurbishment and safety upgradation for its life extension. 相似文献
3.
The thermal degradation of cellulose and its phosphorylated products (phosphates, diethylphosphate, and diphenylphosphate) were studied in air and nitrogen by differential thermal analysis and dynamic thermogravimetry from ambient temperature to 750°C. From the resulting data various thermodynamic parameters were obtained following the methods of Broido and Freeman and Carroll. The values of Ea for decomposition for phosphorylated cellulose were found to be in the range 55–138 kJ mol?1 in air and 85–152 kJ mol?1 in nitrogen and depended upon the percent of phosphorus contents in the samples. The mass spectrum of cellobiose phosphate indicated the absence of the molecular ion, indicating that the compound was thermally unstable. The IR spectra of the pyrolysis residues of cellulose phosphate gave indication of formation of a compound having C?O and P?O groups. A fire retardancy mechanism for the thermal degradation of cellulose phosphate has been proposed. 相似文献
4.
Multifocus image fusion is the process of obtaining a single image from multiple partially focused images such that the newly formed image consists of the well-defined information extracted from each source image. This paper proposes the use of saliency of the source images based on Mutual Spectral Residual. Spectral Residual brings out the unique/salient features of an image in frequency domain. The idea of proposed mutual spectral residual is to emphasize the relative unique features of a source image with respect to the other source images. The relative unique features are utilized to form saliency maps for each source image. These saliency maps can clearly indicate the focused and defocused parts of an image. Based on the saliency maps obtained, the image fusion takes place in spatial domain. Visual inspection and quantitative evaluation of the fused images obtained by the proposed method, using different evaluation metrics, demonstrate its effectiveness over several existing image fusion methods. 相似文献
5.
Given a graph with edges colored Red and Blue, we study the problem of sampling and approximately counting the number of matchings with exactly k
Red edges. We solve the problem of estimating the number of perfect matchings with exactly k
Red edges for dense graphs. We study a Markov chain on the space of all matchings of a graph that favors matchings with k
Red edges. We show that it is rapidly mixing using non-traditional canonical paths that can backtrack. We show that this chain
can be used to sample matchings in the 2-dimensional toroidal lattice of any fixed size ℓ with k
Red edges, where the horizontal edges are Red and the vertical edges are Blue.
An extended abstract appeared in J.R. Correa, A. Hevia and M.A. Kiwi (eds.) Proceedings of the 7th Latin American Theoretical Informatics Symposium, LNCS 3887, pp. 190–201, Springer, 2006.
N. Bhatnagar’s and D. Randall’s research was supported in part by NSF grants CCR-0515105 and DMS-0505505.
V.V. Vazirani’s research was supported in part by NSF grants 0311541, 0220343 and CCR-0515186.
N. Bhatnagar’s and E. Vigoda’s research was supported in part by NSF grant CCR-0455666. 相似文献
6.
This paper presents a new semi-blind reference watermarking scheme based on discrete wavelet transform(DWT) and singular value decomposition(SVD) for copyright protection and authenticity. We are using a gray scale logo image as watermark instead of randomly generated Gaussian noise type watermark. For watermark embedding, the original image is transformed into wavelet domain and a reference sub-image is formed using directive contrast and wavelet coefficients. We embed watermark into reference image by modifying the singular values of reference image using the singular values of the watermark. A reliable watermark extraction scheme is developed for the extraction of watermark from distorted image. Experimental evaluation demonstrates that the proposed scheme is able to withstand a variety of attacks. We show that the proposed scheme also stands with the ambiguity attack also. 相似文献
7.
8.
This article proposes several two-timescale simulation-based actor-critic algorithms for solution of infinite horizon Markov
Decision Processes with finite state-space under the average cost criterion. Two of the algorithms are for the compact (non-discrete)
action setting while the rest are for finite-action spaces. On the slower timescale, all the algorithms perform a gradient
search over corresponding policy spaces using two different Simultaneous Perturbation Stochastic Approximation (SPSA) gradient
estimates. On the faster timescale, the differential cost function corresponding to a given stationary policy is updated and
an additional averaging is performed for enhanced performance. A proof of convergence to a locally optimal policy is presented.
Next, we discuss a memory efficient implementation that uses a feature-based representation of the state-space and performs
TD(0) learning along the faster timescale. The TD(0) algorithm does not follow an on-line sampling of states but is observed
to do well on our setting. Numerical experiments on a problem of rate based flow control are presented using the proposed
algorithms. We consider here the model of a single bottleneck node in the continuous time queueing framework. We show performance
comparisons of our algorithms with the two-timescale actor-critic algorithms of Konda and Borkar (1999) and Bhatnagar and Kumar (2004). Our algorithms exhibit more than an order of magnitude better performance over those of Konda and Borkar (1999).
相似文献
Shalabh Bhatnagar (Corresponding author)Email: |
9.
10.
Saswata Chakravarty Sindhu Padakandla Shalabh Bhatnagar 《International Transactions in Operational Research》2014,21(5):737-760
We propose a simulation‐based algorithm for computing the optimal pricing policy for a product under uncertain demand dynamics. We consider a parameterized stochastic differential equation (SDE) model for the uncertain demand dynamics of the product over the planning horizon. In particular, we consider a dynamic model that is an extension of the Bass model. The performance of our algorithm is compared to that of a myopic pricing policy and is shown to give better results. Two significant advantages with our algorithm are as follows: (a) it does not require information on the system model parameters if the SDE system state is known via either a simulation device or real data, and (b) as it works efficiently even for high‐dimensional parameters, it uses the efficient smoothed functional gradient estimator. 相似文献