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1.
Evangelopoulos Xenophon Brockmeier Austin J. Mu Tingting Goulermas John Y. 《Machine Learning》2019,108(4):595-626
Machine Learning - We propose a set of highly scalable algorithms for the combinatorial data analysis problem of seriating similarity matrices. Seriation consists of finding a permutation of data... 相似文献
2.
Dr. Yahu A. Liu Dr. Qihui Jin Qiang Ding Dr. Xueshi Hao Tingting Mo Shanshan Yan Dr. Yefen Zou Dr. Zhihong Huang Xiaoyue Zhang Wenqi Gao Dr. Tom Y.-H. Wu Chun Li Dr. Badry Bursalaya Dr. Michael Di Donato Dr. You-Qing Zhang Lisa Deaton Dr. Weijun Shen Dr. Brandon Taylor Anwesh Kamireddy Dr. George Harb Dr. Jing Li Dr. Yong Jia Dr. Andrew M. Schumacher Dr. Bryan Laffitte Dr. Richard Glynne Dr. Shifeng Pan Dr. Peter McNamara Dr. Valentina Molteni Dr. Jon Loren 《ChemMedChem》2020,15(16):1562-1570
Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell mass are less developed. Promoting β-cell proliferation with low-molecular-weight inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) offers the potential to treat diabetes with oral therapies by restoring β-cell mass, insulin content and glycemic control. GNF4877, a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) was previously reported to induce primary human β-cell proliferation in vitro and in vivo. Herein, we describe the lead optimization that lead to the identification of GNF4877 from an aminopyrazine hit identified in a phenotypic high-throughput screening campaign measuring β-cell proliferation. 相似文献
3.
J. B. Quinn G. E. Schumacher L. W. Schultheis 《Journal of Failure Analysis and Prevention》2004,4(1):41-46
Several days after heart surgery, a patient discovered his upper right canine tooth had broken at the root. Such tooth damage,
recognized post-operatively, is usually assumed to be caused by blunt mechanical force from an instrument used by the anesthesiologist
during placement of a breathing tube at the start of surgery.
In this case, the patient had saved the crown portion of the broken tooth, and it was possible to examine the root fracture
characteristics. The curvature and direction of the crack path and natural tooth situation suggested that failure could be
described through a cantilever beam model. This was confirmed when a whole extracted sample tooth was embedded and broken
by a measured force in a manner consistent with the model. The resulting fracture surface matched that of the patient’s broken
canine tooth. However, the high load and force direction necessary to fracture the root was inconsistent with forces applied
during the anesthesia procedure. The failure analysis and further investigation indicated tooth clenching on the breathing
tube during recovery was the likely cause of fracture.
This paper presents an alternate explanation for intubation-related dental injury, demonstrates the practicality of fractographic
analysis of biological materials, and introduces a methodology for simulating in vitro tooth settings for mechanical testing. 相似文献
4.
Nicholas Biery Marc De Graef Jack Beuth Rafel Raban Andrew Elliott Tresa M. Pollock Curt Austin 《Metallurgical and Materials Transactions A》2002,33(10):3127-3136
Tensile experiments have been performed on specimens of four different investment-cast TiAl-based alloys with variations in
casting conditions. The average ductilities obtained in these experiments vary between approximately 0.8 to 2.0 pct plastic
strain to failure in tension. By using the three-parameter form of the Weibull relation, with the 0.2 pct offset yield strength
as the minimum failure strength, the resulting variability in the data can be quantified and is found to be similar for those
alloys with similar microstructural scale (grain size). Large variations in lamellar volume fraction, segregation, and phase
distribution have a minor influence on property variability, compared to changes in the scale of the grain structure caused
by either variations in cooling rate during casting or the addition of grain refiners. 相似文献
5.
Jen-Chwen Lin T. Leo Ngai Y. Austin Chang 《Metallurgical and Materials Transactions A》1986,17(7):1241-1245
Defect equilibria for binary semiconducting compound phases which exhibit ionized native donor and acceptor defects were considered,
and equations describing the pressure-temperature-composition relationships for these compound phases were derived. These
equations were used to analyze experimental data from the literature for tin telluride. Excellent agreement was obtained between
calculated thermodynamic and phase boundary values and experimental data. The approach presented is readily extended to obtain
equations for the thermodynamic properties of ternary and higher order semiconducting compound phases. 相似文献
6.
7.
Comparison of two methods of surfactant administration and the effect on dosing-associated hypoxemia
M Nelson JJ Nicks MA Becker LA Vrlenich V Bhatt-Mehta RE Schumacher 《Canadian Metallurgical Quarterly》1997,17(6):450-454
OBJECTIVE: The purpose of our study was to test the hypothesis that surfactant dosing through a proximal sideport adapter on an endotracheal tube leads to more dosing-associated hypoxemia compared with a method of dosing that uses a double-lumen endotracheal tube. STUDY DESIGN: Using adequate sample size to compare significant changes in O2 saturation (power > 0.8, alpha < 0.05) we enrolled 36 infants with respiratory distress syndrome in this randomized trial. A 10% change in O2 saturation was considered clinically significant. Nineteen infants received 38 doses of surfactant through the sideport adapter. Seventeen infants received 31 doses of surfactant through the nonventilation lumen of a double-lumen endotracheal tube. Two main outcome measures were assessed: time-averaged O2 saturation values 30 minutes after dosing and the largest absolute fall in O2 saturation for each patient. RESULTS AND CONCLUSIONS: Time-averaged O2 saturation measures were higher in the proximal sideport group (p = 0.02), but the magnitude of difference was probably not clinically significant. No significant difference was detected between groups when we compared largest absolute drop in O2 saturation. Secondary analyses found no effect of birth weight or dose number (second vs third dose) on either outcome measure. 相似文献
8.
S Schumacher H Volkmer F Buck A Otto A Tarnók S Roth FG Rathjen 《Canadian Metallurgical Quarterly》1997,136(4):895-906
Chicken acidic leucine-rich EGF-like domain containing brain protein (CALEB) was identified by combining binding assays with immunological screens in the chicken nervous system as a novel member of the EGF family of differentiation factors. cDNA cloning indicates that CALEB is a multidomain protein that consists of an NH2-terminal glycosylation region, a leucine-proline-rich segment, an acidic box, a single EGF-like domain, a transmembrane, and a short cytoplasmic stretch. In the developing nervous system, CALEB is associated with glial and neuronal surfaces. CALEB is composed of a 140/130-kD doublet, an 80-kD band, and a chondroitinsulfate-containing 200-kD component. The latter two components are expressed in the embryonic nervous system and are downregulated in the adult nervous system. CALEB binds to the extracellular matrix glycoproteins tenascin-C and -R. In vitro antibody perturbation experiments reveal a participation of CALEB in neurite formation in a permissive environment. 相似文献
9.
We investigated changes in the anterior tibial muscle during lengthening of the lower leg in rabbits. In 37 rabbits, an osteotomy of the right middle tibia was performed and was fixed by a unilateral external fixator. The rabbits were randomized into 6 groups. In groups 1, 2, and 3 the tibiae were distracted 0.5 mm/day. In groups 1 and 2, the rabbits were killed after 14 and 28 days of distraction, respectively, and in group 3 after 28 days of distraction, followed by 14 days of rest. Groups 1a, 2a, and 3a served as controls. They were treated similarly as groups 1, 2, and 3, but no distraction was performed. Proliferating cell nuclei were labeled with 5-bromo-2-deoxyuridine and were identified by immunohistochemical staining. The weight of the muscle was measured. During bone lengthening the muscle showed signs of growth, as indicated by increasing weight and number of proliferating cell nuclei. This was observed only during lengthening and it ceased when the lengthening was stopped. 相似文献
10.
A basic problem in buying a CAD system arises from the fact that, if you do not know where you are going, any road will take you there. The solution is to plan where you want to go, and the rest more-or-less follows. The author shows how there are several ways in which you can acquire the expertise so that you can define your destination (i.e. your total CAD requirement) and hence plan your route (the justification and selection of the system) 相似文献