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排序方式: 共有453条查询结果,搜索用时 31 毫秒
1.
Marco Bocchetti Maria Grazia Ferraro Filippo Ricciardiello Alessandro Ottaiano Amalia Luce Alessia Maria Cossu Marianna Scrima Wing-Yan Leung Marianna Abate Paola Stiuso Michele Caraglia Silvia Zappavigna Tung On Yau 《International journal of molecular sciences》2021,22(8)
Colorectal cancer (CRC) is the third most deadly cancer worldwide, and inflammatory bowel disease (IBD) is one of the critical factors in CRC carcinogenesis. IBD is responsible for an unphysiological and sustained chronic inflammation environment favoring the transformation. MicroRNAs (miRNAs) belong to a class of highly conserved short single-stranded segments (18–25 nucleotides) non-coding RNA and have been extensively discussed in both CRC and IBD. However, the role of miRNAs in the development of colitis-associated CRC (CAC) is less clear. The aim of this review is to summarize the major upregulated (miR-18a, miR-19a, miR-21, miR-31, miR-155 and miR-214) and downregulated (miR-124, miR-193a-3p and miR-139-5p) miRNAs in CAC, and their roles in genes’ expression modulation in chronic colonic-inflammation-induced carcinogenesis, including programmed cell-death pathways. These miRNAs dysregulation could be applied for early CAC diagnosis, to predict therapy efficacy and for precision treatment. 相似文献
2.
Multifilament Ag-sheathed BiPbSrCaCuO (2223) superconducting tapes containing 49 filaments were fabricated by the powder-in-tube route and the roll-anneal process. The transport critical current densityJ
c
was 1.3×104 A cm–2 at 77 K and 7×104 A cm–2 at 4.2 K in self-field. A 12-m-long tape was used to construct superconducting solenoids (50, 28, and 14 mm internal diameters) generating dc fields 380–1070 G at 4.2 K. Measurements of the variation ofJ
c
with field (0–1.6 T) and bend strain (0–5%) are used to explain the performance of the solenoids. The critical bend strain of tapes was about 1.5%. 相似文献
3.
Chi-Chao Hung Oates A.S. Horng-Chih Lin Yu-En Chang P. Jia-Lian Wang Cheng-Chung Huang You-Wen Yau 《Device and Materials Reliability, IEEE Transactions on》2007,7(3):462-467
This paper provides a new understanding of metal-insulator-metal-capacitor-degradation behavior under a wide range of constant-current-stress conditions. It was found that capacitance degrades with stress, but the behavior of the degradation strongly depends on the stress-current density. At high stress levels, the capacitance increases logarithmically as the injection charge increases until dielectric breakdown occurs. At lower stress conditions, the degradation rate is proportional to the stress current and reverses after a certain period of time. A metal-insulator interlayer is observed using cross-sectional transmission-electron-microscopy micrographs, which possibly explains this reversal phenomenon. 相似文献
4.
Hoksung Yau Yunpeng Pan Leyuan Shi 《Automation Science and Engineering, IEEE Transactions on》2008,5(2):349-360
This paper addresses the general single-machine earliness-tardiness problem with distinct release dates, due dates, and unit costs. The aim of this research is to obtain an exact nonpreemptive solution in which machine idle time is allowed. In a hybrid approach, we formulate and then solve the problem using dynamic programming (DP), while incorporating techniques from branch-and-bound (BB). This approach (DP-BB) has been proven to be effective in solving certain types of scheduling problems. We further propose a new adaptation of the approach to a general problem with a nonregular objective function. To address some shortcomings of DP-BB, we also apply a BB approach in which partial dynamic programming dominance (BB-PDP) is exploited. Computational experiments were conducted with randomly generated test instances in order to evaluate the effectiveness of the two approaches. The results clearly showed that our new approaches can solve all the instances with up to 40 jobs and most of the instances with 50 jobs, which outperforms those frequently used approaches in scheduling research. 相似文献
5.
Lee Y.-H. Yau L.D. Hansen E. Chau R. Sabi B. Hossaini S. Asakawa B. 《Electron Devices, IEEE Transactions on》1993,40(1):163-168
It is shown that while gate oxides containing thermal/LPCVD composite oxide have lower defect densities than gates using only thermal oxides, they are more susceptible to hot-carrier degradation. The hot-carrier-induced degradation of composite oxides is worse in p-channel MOSFETs than in n-channel MOSFETs. This sensitivity of p-channel MOSFETs is caused by higher electron trapping levels in LPCVD oxides. For 150-Å gate technology, the hot-carrier-degradation resistance of thermal/LPCVD composite gate oxides with a 70-Å or thicker thermal oxide layer approaches that of high-quality pure thermal oxide 相似文献
6.
Zhengyu Su Jian Sun Xianfeng Gu Feng Luo Shing-Tung Yau 《Engineering with Computers》2014,30(4):475-486
In geometric modeling, surface parameterization plays an important role for converting triangle meshes to spline surfaces. Parameterization will introduce distortions. Conventional parameterization methods emphasize on angle-preservation, which may induce huge area distortions and cause large spline fitting errors and trigger numerical instabilities.To overcome this difficulty, this work proposes a novel area-preserving parameterization method, which is based on an optimal mass transport theory and convex geometry. Optimal mass transport mapping is measure-preserving and minimizes the transportation cost. According to Brenier’s theorem, for quadratic distance transportation costs, the optimal mass transport map is the gradient of a convex function. The graph of the convex function is a convex polyhedron with prescribed normal and areas. The existence and the uniqueness of such a polyhedron have been proved by the Minkowski-Alexandrov theorem in convex geometry. This work gives an explicit method to construct such a polyhedron based on the variational principle, and formulates the solution to the optimal transport map as the unique optimum of a convex energy. In practice, the energy optimization can be carried out using Newton’s method, and each iteration constructs a power Voronoi diagram dynamically. We tested the proposal algorithms on 3D surfaces scanned from real life. Experimental results demonstrate the efficiency and efficacy of the proposed variational approach for the optimal transport map. 相似文献
7.
There are still many challenging problems in facial gender recognition which is mainly due to the complex variances of face appearance. Although there has been tremendous research effort to develop robust gender recognition over the past decade, none has explicitly exploited the domain knowledge of the difference in appearance between male and female. Moustache contributes substantially to the facial appearance difference between male and female and could be a good feature to be incorporated into facial gender recognition. Little work on moustache segmentation has been reported in the literature. In this paper, a novel real-time moustache detection method is proposed which combines face feature extraction, image decolorization and texture detection. Image decolorization, which converts a color image to grayscale, aims to enhance the color contrast while preserving the grayscale. On the other hand, moustache appearance is normally grayscale surrounded by the skin color face tissue. Hence, it is a fast and efficient way to segment the moustache by using the decolorization technology. In order to make the algorithm robust to the variances of illumination and head pose, an adaptive decolorization segmentation has been proposed in which both the segmentation threshold selection and the moustache region following are guided by some special regions defined by their geometric relationship with the salient facial features. Furthermore, a texture-based moustache classifier is developed to compensate the decolorization-based segmentation which could detect the darker skin or shadow around the mouth caused by the small lines or skin thicker from where he/she smiles as moustache. The face is verified as the face containing a moustache only when it satisfies: (1) a larger moustache region can be found by applying the decolorization segmentation; (2) the segmented moustache region is detected as moustache by the texture moustache detector. The experimental results on color FERET database showed that the proposed approach can achieve 89 % moustache face detection rate with 0.1 % false acceptance rate. By incorporating the moustache detector into a facial gender recognition system, the gender recognition accuracy on a large database has been improved from 91 to 93.5 %. 相似文献
8.
S. J. Liao D. Y. Chang H. J. Chen L. S. Tsou J. R. Ho H. T. Yau W. H. Hsieh James T. Wang Y. C. Su 《Polymer Engineering and Science》2004,44(5):917-928
Optimal process conditions of thin‐wall injection molding of a cellular phone cover were investigated with the consideration of interaction effects between process parameters. L27 experimental tests based on Taguchi's method were performed, and then Cyclone Scanner, PolyCAD and PolyWorks were used to measure the shrinkage and warpage of the thin‐wall injected parts to determine the optimal process conditions. Based on the results of the analysis of variables and the F‐test, interaction effects for each observed factor were determined. The results indicated that the packing pressure was the most important process parameter affecting the shrinkage and warpage of the thin‐wall part. The optimal process conditions were different for the shrinkage and the warpage. This was because during the injection process, the mechanisms affecting shrinkage or warpage were different. Compared with the results obtained with simplified thin‐wall parts in the literature, it was found that the geometry of a real commercial part did affect the optimal process conditions and the order of influence of process parameters. The optimal process conditions determined by Taguchi's method for reducing the shrinkage and warpage were verified experimentally in this work. Polym. Eng. Sci. 44:917–928, 2004. © 2004 Society of Plastics Engineers. 相似文献
9.
Mihai Burcea Wing-Kai Hon Hsiang-Hsuan Liu Prudence W. H. Wong David K. Y. Yau 《Journal of Scheduling》2016,19(6):687-699
We study an offline scheduling problem arising in demand response management in a smart grid. Consumers send in power requests with a flexible set of timeslots during which their requests can be served. For example, a consumer may request the dishwasher to operate for 1 h during the periods 8am to 11am or 2pm to 4pm. The grid controller, upon receiving power requests, schedules each request within the specified duration. The electricity cost is measured by a convex function of the load in each timeslot. The objective of the problem is to schedule all requests with the minimum total electricity cost. As a first attempt, we consider a special case in which the power requirement and the duration a for which a request needs service are both unit-size. For this problem, we present a polynomial time offline algorithm that gives an optimal solution and shows that the time complexity can be further improved if the given set of timeslots forms a contiguous interval. 相似文献
10.
Password-authenticated key exchange (PAKE) protocols allow parties to share secret keys in an authentic manner based on an easily memorizable password. Recently, Lu and Cao proposed a three-party password-authenticated key exchange protocol, so called S-3PAKE, based on ideas of the Abdalla and Pointcheval two-party SPAKE extended to three parties. S-3PAKE can be seen to have a structure alternative to that of another three-party PAKE protocol (3PAKE) by Abdalla and Pointcheval. Furthermore, a simple improvement to S-3PAKE was proposed very recently by Chung and Ku to resist the kind of attacks that applied to earlier versions of 3PAKE. In this paper, we show that S-3PAKE falls to unknown key-share attacks by any other client, and undetectable online dictionary attacks by any adversary. The latter attack equally applies to the recently improved S-3PAKE. Indeed, the provable security approach should be taken when designing PAKEs; and furthermore our results highlight that extra cautions still be exercised when defining models and constructing proofs in this direction. 相似文献