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排序方式: 共有388条查询结果,搜索用时 15 毫秒
1.
Theodoros Eleftheriadis Georgios Pissas Marta Crespo Evdokia Nikolaou Vassilios Liakopoulos Ioannis Stefanidis 《International journal of molecular sciences》2021,22(4)
Direct allorecognition is the earliest and most potent immune response against a kidney allograft. Currently, it is thought that passenger donor professional antigen-presenting cells (APCs) are responsible. Further, many studies support that graft ischemia-reperfusion injury increases the probability of acute rejection. We evaluated the possible role of primary human proximal renal tubular epithelial cells (RPTECs) in direct allorecognition by CD4+ T-cells and the effect of anoxia-reoxygenation. In cell culture, we detected that RPTECs express all the required molecules for CD4+ T-cell activation (HLA-DR, CD80, and ICAM-1). Anoxia-reoxygenation decreased HLA-DR and CD80 but increased ICAM-1. Following this, RPTECs were co-cultured with alloreactive CD4+ T-cells. In T-cells, zeta chain phosphorylation and c-Myc increased, indicating activation of T-cell receptor and co-stimulation signal transduction pathways, respectively. T-cell proliferation assessed with bromodeoxyuridine assay and with the marker Ki-67 increased. Previous culture of RPTECs under anoxia raised all the above parameters in T-cells. FOXP3 remained unaffected in all cases, signifying that proliferating T-cells were not differentiated towards a regulatory phenotype. Our results support that direct allorecognition may be mediated by RPTECs even in the absence of donor-derived professional APCs. Also, ischemia-reperfusion injury of the graft may enhance the above capacity of RPTECs, increasing the possibility of acute rejection. 相似文献
2.
Crespo Juan-José Sánchez José L. Alfaro-Cortés Francisco J. Flich José Duato José 《The Journal of supercomputing》2021,77(11):12826-12856
The Journal of Supercomputing - Deadlock-free dynamic network reconfiguration process is usually studied from the routing algorithm restrictions and resource reservation perspective. The dynamic... 相似文献
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Gillespie J.K. Fitch R.C. Sewell J. Dettmer R. Via G.D. Crespo A. Jenkins T.J. Luo B. Mehandru R. Kim J. Ren F. Gila B.P. Onstine A.H. Abernathy C.R. Pearton S.J. 《Electron Device Letters, IEEE》2002,23(9):505-507
The low temperature (100°C) deposition of Sc2O3 or MgO layers is found to significantly increase the output power of AlGaN/GaN HEMTs. At 4 GHz, there was a better than 3 dB increase in output power of 0.5×100 μm2 HEMTs for both types of oxide passivation layers. Both Sc2 O3 and MgO produced larger output power increases at 4 GHz than conventional plasma-enhanced chemical vapor deposited (PECVD) SiNx passivation which typically showed ⩽2 dB increase on the same types of devices. The HEMT gain also in general remained linear over a wider input power range with the Sc2O3 or MgO passivation. These films appear promising for reducing the effects of surface states on the DC and RF performance of AlGaN/GaN HEMTs 相似文献
7.
Modelling students' behaviours has reached a status that can only be overcome by improving the ability of predicting the results on teamwork. Indeed, teamwork is an important piece on the learning process, but understanding their mechanisms and predicting the results achieved is far from being solved by traditional classifiers. In this paper, we address the problem of predicting teamwork results, and propose a recommender system that suggests new teams, in the context of a given curricular unit. Any student, who is looking for a team, may use the system; in particular, he may ask for the best team to join, either considering all available colleagues or just the set of his previous teammates. Our system makes use of social network analysis and classification methods as the algorithmic core of the decision‐making process. System evaluation is presented through a set of experimental results, which report the performance of social network analysis and classification algorithms over real datasets. 相似文献
8.
Dynamic memory allocation has been used for decades. However, it has seldom been used in real-time systems since the worst
case of spatial and temporal requirements for allocation and deallocation operations is either unbounded or bounded but with
a very large bound.
In this paper, a new allocator called TLSF (Two Level Segregated Fit) is presented. TLSF is designed and implemented to accommodate
real-time constraints. The proposed allocator exhibits time-bounded behaviour, O(1), and maintains a very good execution time. This paper describes in detail the data structures and functions provided by
TLSF. We also compare TLSF with a representative set of allocators regarding their temporal cost and fragmentation.
Although the paper is mainly focused on timing analysis, a brief study and comparative analysis of fragmentation incurred
by the allocators has been also included in order to provide a global view of the behaviour of the allocators.
The temporal and spatial results showed that TLSF is also a fast allocator and produces a fragmentation close to that caused
by the best existing allocators.
相似文献
Alfons Crespo (Corresponding author)Email: |
9.
This paper studies connectivity aspects that arise in image operators that process connected components. The focus is on morphological
image analysis (i.e., on increasing image operators) and, in particular, on a robustness property satisfied by certain morphological
filters that is denominated the strong property. The behavior of alternated compositions of openings and closings is investigated
under certain assumptions, particularly connectedness and a connected component preserving condition. It is shown that these
conditions cannot in general guarantee the strong property of certain connected alternated filters because of issues related
to the locality of the filters. As treated in the paper, there have been a series of misunderstandings in the literature concerning
this topic, and it is important to clarify them. The root cause of those problems is discussed, and a solution is indicated.
The class of connected openings and closings used to build connected alternated filters should therefore be defined to avoid
such situations, since the strong property of alternated filters should be a distinctive characteristic of this class.
相似文献
Victor MaojoEmail: |
10.
Rodríguez J Fernández S Palacios SL Crespo RD Fernández JM Guinea A Virgós JM Olivares J 《Applied optics》1995,34(27):6172-6179
We present a theoretical method that makes it possible to analyze three-dimensional (3-D) integrated optical waveguides with arbitrary refractive-index profiles. With this method it is easy to obtain effective indexes, propagation constants, and coupling-switching properties of planar and channel optical waveguides. This theoretical approach involves one's modeling the original optical waveguide by means of an equivalent optical waveguide whose effective index is evaluated by the application of a technique that we call the asymptotic effective-index method. The numerical values show good convergence and accuracy for effective indexes, propagation constants, and coupling-switching characteristics. Theoretical and experimental results are given. 相似文献