Deep autoencoders for feature learning with embeddings for recommendations: a novel recommender system solution

Neural Computing and Applications - We propose “Deep Autoencoders for Feature Learning in Recommender Systems,” a novel discriminative model based on the incorporation of features from...     

Modified determination of 2-thiobarbituric acid value in fats and oils

Several methods for the determination of TBA-value were compared with a new direct modification (omitting the previous distillation), using 1-butanol as the sole solvent. The absorbance is measured at 530 nm after heating to 95 degrees C for 120 min, and cooling. The effect of variables was tested by the Youdens ruggedness test (reaction time, temperature, cooling, concentration of sample, thiobarbituric acid, water, heavy metals, antioxidants, chelating agents, bubbling with oxygen or nitrogen). The Lambert-Beers law is valid in the absorbance range between 0.05 and 0.8. The repeatability is better than that of the Dzikowskis procedure and comparable with those of more complicated distillation methods. The standard deviation is in a linear relation with the absorbance (range 0.1-1.0). The method was found satisfactory for evaluating lard, cooking fat, soybean, sunflower, and rapeseed oils in the stage of beginning rancidity.     

Analysis of the validity of vaginal-cervical cytologic examination in 162 pre- and post-menopausal patients

The authors examine 162 cervico-vaginal smears of women in peri-menopause presenting cellular alterations (ASCUS). These patients were treated with a local topic therapy as the persistence of these alterations in 23 cases (14.2%) second level analyses were performed: gynecological visit, colposcopy and biopsy. In addition to inflammatory aspects 2 in situ carcinomas and 2 moderate dysplasias were recorded. We believe therefore that cytology could be a valid aid also in pre-menopausal women in the cervico-vaginal pathology.     

Registration techniques for using imperfect and partially calibrated devices in planar multi-projector displays

Multi-projector displays today are automatically registered, both geometrically and photometrically, using cameras. Existing registration techniques assume pre-calibrated projectors and cameras that are devoid of imperfections such as lens distortion. In practice, however, these devices are usually imperfect and uncalibrated. Registration of each of these devices is often more challenging than the multi-projector display registration itself. To make tiled projection-based displays accessible to a layman user we should allow the use of uncalibrated inexpensive devices that are prone to imperfections. In this paper, we make two important advances in this direction. First, we present a new geometric registration technique that can achieve geometric alignment {\em in the presence of severe projector lens distortion} using a relatively inexpensive low-resolution camera. This is achieved via a closed-form model that relates the projectors to cameras, in planar multi-projector displays, using rational Bezier patches. This enables us to geometrically calibrate a 3000 x 2500 resolution planar multi-projector display made of 3 x 3 array of nine severely distorted projectors using a low resolution (640 x 480) VGA camera. Second, we present a photometric self-calibration technique for a projector-camera pair. This allows us to photometrically calibrate the same display made of nine projectors using a photometrically uncalibrated camera. To the best of our knowledge, this is the first work that allows geometrically imperfect projectors and photometrically uncalibrated cameras in calibrating multi-projector displays.     

Spray drying of drug-swellable dispersant suspensions for preparation of fast-dissolving,high drug-loaded,surfactant-free nanocomposites

Bioavailability of a poorly soluble drug can be improved by preparing a drug nanosuspension and subsequently drying it into nanocomposite microparticles (NCMPs). Unfortunately, drug nanoparticles aggregate during milling and drying, causing incomplete recovery and slow dissolution. The aim of this study is to investigate the impact of various classes of dispersants on drug dissolution from drug NCMPs, with the ultimate goal of enhancing the bioavailability of poorly water-soluble drugs via high drug nanoparticle loaded, surfactant-free NCMPs. Precursor suspensions of griseofulvin (GF, model drug) nanoparticles in the presence of various dispersants were prepared via wet stirred media milling and spray dried to form the NCMPs. Hydroxypropyl cellulose (HPC, polymer) alone and with sodium dodecyl sulfate (SDS, surfactant) was used as a base-line stabilizer/dispersant during milling. Two swellable crosslinked polymers, croscarmellose sodium (CCS) and sodium starch glycolate (SSG), and a conventional soluble matrix former, Mannitol, were used in addition to HPC. Besides being used as-received, CCS was also wet co-milled with GF for two different durations to examine the impact of CCS particle size. Laser diffraction, scanning electron microscopy, powder X-ray diffraction (XRD), UV spectroscopy, NCMP redispersion and dissolution tests were used for characterization. The results show that incorporation of CCS/SSG, preferably wet-milled to a wide particle size distribution, into the spray-dried NCMPs resulted in fast release and dispersion of drug nanoparticle clusters. The swellable dispersants were superior to Mannitol in dissolution enhancement, and could achieve fast release comparable to SDS, demonstrating the feasibility of spray drying to prepare high drug-loaded, surfactant-free nanocomposites.     

Expression of human aldehyde dehydrogenase-3 associated with hepatocellular carcinoma: promoter regions and nuclear protein factors related to the expression

Studies in our laboratory have shown that as early as day 8.5 of development, mouse yolk sac cells can generate T cells when placed in a thymic microenvironment. At this stage, yolk sac cells can also differentiate into myeloid cells in vitro. B cell differentiation in vitro was achieved with day 9 yolk sac by providing a bone marrow stromal feeder layer. We have now established endothelial cell lines and clones from yolk sacs of day 8-12 mouse embryos. These vary in their ability to support stem cell maintenance and differentiation. Our principal work has been carried out with day 12 cloned endothelial cell lines. One clone supported the > 100 fold expansion of yolk sac hematopoietic stem cells that subsequently could generate B cells, T cells and myeloid cells both in vitro and in vivo. Preliminary experiments with endothelial cells from younger embryos are also described.     

An impulsive dynamical systems framework for reset control systems

Impulsive dynamical systems is a well-established area of dynamical systems theory, and it is used in this work to analyse several basic properties of reset control systems: existence and uniqueness of solutions, and continuous dependence on the initial condition (well-posedness). The work scope is about reset control systems with a linear and time-invariant base system, and a zero-crossing resetting law. A necessary and sufficient condition for existence and uniqueness of solutions, based on the well-posedness of reset instants, is developed. As a result, it is shown that reset control systems (with strictly proper plants) do not have Zeno solutions. It is also shown that full reset and partial reset (with a special structure) always produce well-posed reset instants. Moreover, a definition of continuous dependence on the initial condition is developed, and also a sufficient condition for reset control systems to satisfy that property. Finally, this property is used to analyse sensitivity of reset control systems to sensor noise. This work also includes a number of illustrative examples motivating the key concepts and main results.