The Influence and Interpretation of Surface Parameters for Wetting Transitions in Ternary Mixtures

Starting from a microscopic Hamiltonian defined on a semi-infinite cubic lattice, and employing a mean-field approximation, the surface parameters relevant for wetting in confined ternary mixtures are derived. These are found in terms of the microscopic coupling constants, and yield a physical interpretation of their origins. In comparison with the standard expression for the surface free-energy density, several new terms arising from the derivation are identified. The influence of the surface parameters on a predicted unbinding transition in a mixture of oil, water, and amphiphile demonstrate that existing results are robust to the addition of the extra surface terms.     

Estimating costs of programme services and products using information provided in standard financial statements

OBJECTIVE: To determine whether spectral analysis of unprocessed radiofrequency (RF) signal offers advantages over standard videodensitometric analysis in identifying the morphology of coronary atherosclerotic plaques. METHODS: 97 regions of interest (ROI) were imaged at 30 MHz from postmortem, pressure perfused (80 mm Hg) coronary arteries in saline baths. RF data were digitised at 250 MHz. Two different sizes of ROI were identified from scan converted images, and relative amplitudes of different frequency components were analysed from raw data. Normalised spectra was used to calculate spectral slope (dB/MHz), y-axis intercept (dB), mean power (dB), and maximum power (dB) over a given bandwidth (17-42 MHz). RF images were constructed and compared with comparative histology derived from microscopy and radiological techniques in three dimensions. RESULTS: Mean power was similar from dense fibrotic tissue and heavy calcium, but spectral slope was steeper in heavy calcium (-0.45 (0.1)) than in dense fibrotic tissue (-0.31 (0.1)), and maximum power was higher for heavy calcium (-7.7 (2.0)) than for dense fibrotic tissue (-10.2 (3.9)). Maximum power was significantly higher in heavy calcium (-7.7 (2.0) dB) and dense fibrotic tissue (-10.2 (3.9) dB) than in microcalcification (-13.9 (3.8) dB). Y-axis intercept was higher in microcalcification (-5.8 (1.1) dB) than in moderately fibrotic tissue (-11.9 (2.0) dB). Moderate and dense fibrotic tissue were discriminated with mean power: moderate -20.2 (1.1) dB, dense -14.7 (3.7) dB; and y-axis intercept: moderate -11.9 (2.0) dB, dense -5.5 (5.4) dB. Different densities of fibrosis, loose, moderate, and dense, were discriminated with both y-axis intercept, spectral slope, and mean power. Lipid could be differentiated from other types of plaque tissue on the basis of spectral slope, lipid -0.17 (0.08). Also y-axis intercept from lipid (-17.6 (3.9)) differed significantly from moderately fibrotic tissue, dense fibrotic tissue, microcalcification, and heavy calcium. No significant differences in any of the measured parameters were seen between the results obtained from small and large ROIs. CONCLUSION: Frequency based spectral analysis of unprocessed ultrasound signal may lead to accurate identification of atherosclerotic plaque morphology.     

The effects of sulphur fertilisers on the content of sulpho-amino acids in seeds of cowpea (Vigna unguiculata)

Seed meals of three cowpea (Vigna unguiculata) cultivars, grown in pots containing sulphur-deficient soil supplemented with 0, 0.2, 0.6, 1.8, 5, 15 and 45 parts/10⁶ sulphate-S levels in the soil solution, were examined for total nitrogen, total sulphur and sulpho-amino acid contents. The sulphur content and the ratio of sulphur to nitrogen were found to increase with the increasing level of sulphate-S fertilisation up to ca 5 parts/10⁶. Compared with the control the sulpho-amino acid content in seeds of cowpea TVu 76 increased with S-supplementation up to 5 parts/10⁶ and that of cowpea Sitao Pole increased with S up to 1.8 parts/10⁶. Similar levels (7 and 2 parts/10⁶ respectively) of sulphate-S were required in the soil solution to obtain 95% of the maximum yields of cowpea seeds. The content of sulpho-amino acids in the seeds from 5 parts/10⁶ treatments were similar to those reported for cowpeas grown under field conditions at IITA and elsewhere with adequate levels of soil sulphur for maximum yield.     

Amino acid composition of seed meals of yam bean (Sphenostylis stenocarpa) and lima bean (Phaseolus lunatus)

The amino acid compositions of the seed meals of four varieties of yam bean and one variety of lima bean have been compared with the F.A.O.¹ standard.     

Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry

Naturally selected T-cell receptors (TCRs) are characterised by low binding affinities, typically in the range 1-100 microM. Crystal structures of syngeneic TCRs bound to peptide major histocompatibility complex (pMHC) antigens exhibit a conserved mode of binding characterised by a distinct diagonal binding geometry, with poor shape complementarity (SC) between receptor and ligand. Here, we report the structures of three in vitro affinity enhanced TCRs that recognise the pMHC tumour epitope NY-ESO(157-165) (SLLMWITQC). These crystal structures reveal that the docking mode for the high affinity TCRs is identical to that reported for the parental wild-type TCR, with only subtle changes in the mutated complementarity determining regions (CDRs) that form contacts with pMHC; both CDR2 and CDR3 mutations act synergistically to improve the overall affinity. Comparison of free and bound TCR structures for both wild-type and a CDR3 mutant reveal an induced fit mechanism arising from restructuring of CDR3 loops which allows better peptide binding. Overall, an increased interface area, improved SC and additional H-bonding interactions are observed, accounting for the increase in affinity. Most notably, there is a marked increase in the SC for the central methionine and tryptophan peptide motif over the native TCR.     

The effect of speed-loop bandwidths and line speed on systemnatural frequencies in multispan strip processing systems

Strip processing systems (SPSs) are composed of multiple tension zones. These zones are separated by driven rolls such as bridles, the speed of which is regulated by a closed-loop controller. Given that the typical tension regulator regulates tension by trimming the reference to a closed speed-loop controller, the designer of the tension regulator cannot ignore the effects of closing the speed loop, and line speed, on the SPS natural frequencies. These natural frequencies are typically computed as the eigenvalues of an equivalent translational cascaded spring-mass system. This paper discusses these effects     

Targeting medical students to promote women in surgery

The under-representation of women in surgical subspecialities is a well-aired topic. Most efforts to redress the surgical gender balance have, to date, been directed at opportunities for women in surgical training. We report on a one-day symposium organized by the Royal College of Surgeons of Edinburgh to promote interest in taking up a surgical career, aimed at senior women medical students and newly qualified doctors. Although 130 of the attendees who were surveyed did not change their opinion about the four most off-putting aspects of a surgical career, the symposium succeeded in increasing the appeal of a surgical career in 50%, apparently by the intensive exposure to a large and varied sample of female surgical role models.     

Interfacial Tension and Interface Delocalization Phase Boundary for Strongly Type-I Superconductors

We analytically determine the interface delocalization (or wetting) transition phase boundary in the limit of strongly type-I superconductors. In particular, within Ginzburg–Landau theory we derive an analytic expression for the reduced surface tension, _SC/N, of a type-I superconductor. We find that the truncated expansion (where is the Ginzburg–Landau parameter) is so accurate in the entire type-I regime that derivation of higher-order terms is unnecessary. We further derive an expression for the wall/superconductor interfacial tension which again proves accurate across a broad range of values. These expansions allow us to locate the low- interface delocalization phase boundary accurately, complementing previous numerical results for the wetting phase diagram.