Outstanding Low-Temperature Performance of Structure-Controlled Graphene Anode Based on Surface-Controlled Charge Storage Mechanism

The energy and power performance of lithium (Li)-ion batteries is significantly reduced at low-temperature conditions, which is mainly due to the slow diffusion of Li-ions in graphite anode. Here, it is demonstrated that the effective utilization of the surface-controlled charge storage mechanism through the transition from layered graphite to 3D crumpled graphene (CG) dramatically improves the Li-ion charge storage kinetics and structural stability at low-temperature conditions. The structure-controlled CG anode prepared via a one-step aerosol drying process shows a remarkable rate-capability by delivering ≈206 mAh g^–1 at a high current density of 10 A g^–1 at room temperature. At an extremely low temperature of −40 °C, CG anode still exhibits a high capacity of ≈154 mAh g^–1 at 0.01 A g^–1 with excellent rate-capability and cycling stability. A combination of electrochemical studies and density functional theory (DFT) reveals that the superior performance of CG anode stems from the dominant surface-controlled charge storage mechanism at various defect sites. This study establishes the effective utilization of the surface-controlled charge storage mechanism through structure-controlled graphene as a promising strategy to improve the charge storage kinetics and stability under low-temperature conditions.     

Borderline personality features moderate the effect of a fear induction on impulsivity.

This study examined the effects of laboratory-induced fear on impulsivity among participants who were high (n = 28) or low (n = 44) in borderline personality (BP) features. Participants were randomly assigned to complete a laboratory measure of impulsivity (passive avoidance learning task) following either a neutral mood induction or a fear induction. BP features moderated the association of the emotion condition (fear vs. neutral) with impulsivity: High-BP participants, but not low-BP participants, committed a greater number of impulsive responses in the fear condition compared with the neutral condition. Findings indicated that impulsivity among persons with BP features may not be a trait-like deficit, but rather, depends on emotional context. These findings suggest that future research should examine impulsivity under differing emotional conditions, and that clinical interventions to reduce impulsivity among persons with BP features should focus on responses to emotional contexts. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Coffee with jelly or unbuttered toast: Commissions and omissions are dissociable aspects of everyday action impairment in Alzheimer's disease.

Relative to our understanding of the memory and language deficits associated with Alzheimer's disease (AD), little is known about problems with everyday action performance (i.e., meal preparation, grooming). The resource theory proposes that everyday action problems are best explained by a unitary deficit in general cognitive resources. However, recent research suggests that omission and commission errors may reflect dissociable aspects of action impairment, with only omissions associated with resource limitations. This study examined everyday action performance in 70 participants with AD who also underwent a neuropsychological evaluation. First, correlation and principal component analyses were performed to examine the construct(s) that might explain everyday action impairment. Second, relations between everyday task component(s) and neuropsychological tests were examined by using correlation and regression analyses. Third, differences in everyday action error patterns were examined among participants of comparable overall impairment levels. Results showed omission and commission errors were uncorrelated and distinct components of everyday action performance, predicted by different neuropsychological tests, and differentially distributed even among participants with comparable overall impairment. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Dynamically multiplexed ion mobility time-of-flight mass spectrometry

Ion mobility spectrometry-time-of-flight mass spectrometry (IMS-TOFMS) has been increasingly used in analysis of complex biological samples. A major challenge is to transform IMS-TOFMS to a high-sensitivity, high-throughput platform, for example, for proteomics applications. In this work, we have developed and integrated three advanced technologies, including efficient ion accumulation in an ion funnel trap prior to IMS separation, multiplexing (MP) of ion packet introduction into the IMS drift tube, and signal detection with an analog-to-digital converter, into the IMS-TOFMS system for the high-throughput analysis of highly complex proteolytic digests of, for example, blood plasma. To better address variable sample complexity, we have developed and rigorously evaluated a novel dynamic MP approach that ensures correlation of the analyzer performance with an ion source function and provides the improved dynamic range and sensitivity throughout the experiment. The MP IMS-TOFMS instrument has been shown to reliably detect peptides at a concentration of 1 nM in the presence of a highly complex matrix, as well as to provide a 3 orders of magnitude dynamic range and a mass measurement accuracy of better than 5 ppm. When matched against human blood plasma database, the detected IMS-TOF features were found to yield approximately 700 unique peptide identifications at a false discovery rate (FDR) of approximately 7.5%. Accounting for IMS information gave rise to a projected FDR of approximately 4%. Signal reproducibility was found to be greater than 80%, while the variations in the number of unique peptide identifications were <15%. A single sample analysis was completed in 15 min that constitutes almost 1 order of magnitude improvement compared to a more conventional LC-MS approach.     

Loss of trabeculae by mechano-biological means may explain rapid bone loss in osteoporosis.

Osteoporosis is characterized by rapid and irreversible loss of trabecular bone tissue leading to increased bone fragility. In this study, we hypothesize two causes for rapid loss of bone trabeculae; firstly, the perforation of trabeculae is caused by osteoclasts resorbing a cavity so deep that it cannot be refilled and, secondly, the increases in bone tissue elastic modulus lead to increased propensity for trabecular perforation. These hypotheses were tested using an algorithm that was based on two premises: (i) bone remodelling is a turnover process that repairs damaged bone tissue by resorbing and returning it to a homeostatic strain level and (ii) osteoblast attachment is under biochemical control. It was found that a mechano-biological algorithm based on these premises can simulate the remodelling cycle in a trabecular strut where damaged bone is resorbed to form a pit that is subsequently refilled with new bone. Furthermore, the simulation predicts that there is a depth of resorption cavity deeper than which refilling of the resorption pits is impossible and perforation inevitably occurs. However, perforation does not occur by a single fracture event but by continual removal of microdamage after it forms beneath the resorption pit. The simulation also predicts that perforations would occur more easily in trabeculae that are more highly mineralized (stiffer). Since both increased osteoclast activation rates and increased mineralization have been measured in osteoporotic bone, either or both may contribute to the rapid loss of trabecular bone mass observed in osteoporotic patients.     

The Behavioral Deficit Observed Following Noncontingent Shock in Spinalized Rats Is Prevented by the Protein Synthesis Inhibitor Cycloheximide.

Spinalized rats that receive shock when 1 hind limb is extended (contingent shock) exhibit an increase in flexion duration, a simple form of instrumental learning. Rats that receive shock independent of leg position (noncontingent shock) do not exhibit an increase in flexion duration and fail to learn when tested with contingent shock 24 hr later. It appears that noncontingent shock induces an intraspinal modification that inhibits the capacity to learn. The authors propose that the mechanisms that underlie this effect depend on de novo protein synthesis. To evaluate this hypothesis, the authors gave spinalized rats the protein synthesis inhibitor Cycloheximide (CXM) or saline intrathecally prior to, or immediately after, noncontingent shock exposure. Twenty-four hours later, rats were tested with contingent shock. Rats that received the vehicle and noncontingent shock failed to learn. CXM-treated shocked rats learned normally, suggesting that the learning deficit depends on protein synthesis within the spinal cord. (PsycINFO Database Record (c) 2010 APA, all rights reserved)