Graphs of linear clique-width at most 3

A graph has linear clique-width at most k if it has a clique-width expression using at most k labels such that every disjoint union operation has an operand which is a single vertex graph. We give the first characterisation of graphs of linear clique-width at most 3, and we give the first polynomial-time recognition algorithm for graphs of linear clique-width at most 3. In addition, we present new characterisations of graphs of linear clique-width at most 2. We also give a layout characterisation of graphs of bounded linear clique-width; a similar characterisation was independently shown by Gurski and by Lozin and Rautenbach.     

Numerical and analytical investigation of collapse loads of laced built-up columns

Built-up columns are often used in steel buildings and bridges providing economical solutions in cases of large spans and/or heavy loads. Two main effects should be taken into account in their design that differentiate them from other structural members. One is the significant influence of shear deformations due to their reduced shear rigidity. The second is the interaction between global and local buckling. These effects are addressed here from both a numerical and an analytical point of view for laced built-up columns. It is concluded that the largest loss of capacity occurs when the local and global Euler critical stresses and the yield stress all coincide. This reduction in capacity becomes more prominent in the presence of imperfections, reaching magnitudes in the order of 50%. Despite the detrimental effects of mode interaction many major design codes do not provide sufficient pertinent guidance. In order to address this issue, a simple analytical method is proposed for calculating the collapse load of laced built-up members taking into account the above effects as well as global imperfections, local out-of straightness and plasticity, which is then verified by means of nonlinear finite element analysis, using either beam or shell elements. The proposed method is found to provide improved accuracy in comparison to EC3 specifications in cases of global elastic failure.     

Fuel from plant cell walls: recent developments in second generation bioethanol research

As bioethanol from sugarcane and wheat falls out of favour due to concerns about food security, research is ongoing into genetically engineering model plants and microorganisms to find the optimum cell wall structure for the ultimate second generation bioethanol crop. Charis Cook and Alessandra Devoto highlight here the progress made to tailor the plant cell wall to improve the accessibility of cellulose by acting on the regulation, the structure or the relative composition of other cell wall components to ultimately improve saccharification efficiency. They also consider possible side effects of cell wall modification and focus on the latest advances made to improve the efficiency of digestion of lignocellulosic materials by cell wall degrading microorganisms.     

Modified aluminophosphate molecular sieves: preparation and characterisation

Crystalline microporous aluminium phosphate has been prepared in a variety of ways. The influence of the preparative conditions affecting the solid state properties of the resultant solids were studied. Quencg cooling of the reaction mixture led to a change of crystal morphology, but not in structure. Incorporation of zinc also affected the crystal morphology, but the pore structure was essentially unaltered for both systems.     

How Far Are We from Prescribing Fasting as Anticancer Medicine?

(1) Background: the present review provides a comprehensive and up-to date overview of the potential exploitation of fasting as an anticancer strategy. The rationale for this concept is that fasting elicits a differential stress response in the setting of unfavorable conditions, empowering the survival of normal cells, while killing cancer cells. (2) Methods: the present narrative review presents the basic aspects of the hormonal, molecular, and cellular response to fasting, focusing on the interrelationship of fasting with oxidative stress. It also presents nonclinical and clinical evidence concerning the implementation of fasting as adjuvant to chemotherapy, highlighting current challenges and future perspectives. (3) Results: there is ample nonclinical evidence indicating that fasting can mitigate the toxicity of chemotherapy and/or increase the efficacy of chemotherapy. The relevant clinical research is encouraging, albeit still in its infancy. The path forward for implementing fasting in oncology is a personalized approach, entailing counteraction of current challenges, including: (i) patient selection; (ii) fasting patterns; (iii) timeline of fasting and refeeding; (iv) validation of biomarkers for assessment of fasting; and (v) establishment of protocols for patients’ monitoring. (4) Conclusion: prescribing fasting as anticancer medicine may not be far away if large randomized clinical trials consolidate its safety and efficacy.     

Stretchable Composite Acoustic Transducer for Wearable Monitoring of Vital Signs

A highly flexible, stretchable, and mechanically robust low‐cost soft composite consisting of silicone polymers and water (or hydrogels) is reported. When combined with conventional acoustic transducers, the materials reported enable high performance real‐time monitoring of heart and respiratory patterns over layers of clothing (or furry skin of animals) without the need for direct contact with the skin. The approach enables an entirely new method of fabrication that involves encapsulation of water and hydrogels with silicones and exploits the ability of sound waves to travel through the body. The system proposed outperforms commercial, metal‐based stethoscopes for the auscultation of the heart when worn over clothing and is less susceptible to motion artefacts. The system both with human and furry animal subjects (i.e., dogs), primarily focusing on monitoring the heart, is tested; however, initial results on monitoring breathing are also presented. This work is especially important because it is the first demonstration of a stretchable sensor that is suitable for use with furry animals and does not require shaving of the animal for data acquisition.     

Decoupling Criteria for Inelastic Irregular Primary/Secondary Structural Systems Subject to Seismic Excitation

The present work deals with the dynamic response of structures that are irregular in height, consisting of two parts, a lower part made of concrete and an upper part made of steel. Irregularity is due to different dynamic responses of the two parts, here expressed by their different damping ratios and inelastic material laws. The seismic design of such structures is not satisfactorily covered by current design codes, especially if a decoupled procedure is chosen for the analysis, where the lower part is excited first and its response is used as excitation for the upper part. The present paper aims at contributing toward better understanding of the interaction between the two parts and at proposing improved decoupling criteria for the seismic analysis of inelastic primary-secondary systems. Toward that goal, each part is modeled as a one-degree-of-freedom system, and the maximum responses of coupled and decoupled inelastic time history analyses are compared over a wide range of dynamic characteristics and strength levels of the two parts. The results are presented in the form of error levels between the two alternative analysis procedures.