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排序方式: 共有1086条查询结果,搜索用时 15 毫秒
1.
Marco Bocchetti Maria Grazia Ferraro Filippo Ricciardiello Alessandro Ottaiano Amalia Luce Alessia Maria Cossu Marianna Scrima Wing-Yan Leung Marianna Abate Paola Stiuso Michele Caraglia Silvia Zappavigna Tung On Yau 《International journal of molecular sciences》2021,22(8)
Colorectal cancer (CRC) is the third most deadly cancer worldwide, and inflammatory bowel disease (IBD) is one of the critical factors in CRC carcinogenesis. IBD is responsible for an unphysiological and sustained chronic inflammation environment favoring the transformation. MicroRNAs (miRNAs) belong to a class of highly conserved short single-stranded segments (18–25 nucleotides) non-coding RNA and have been extensively discussed in both CRC and IBD. However, the role of miRNAs in the development of colitis-associated CRC (CAC) is less clear. The aim of this review is to summarize the major upregulated (miR-18a, miR-19a, miR-21, miR-31, miR-155 and miR-214) and downregulated (miR-124, miR-193a-3p and miR-139-5p) miRNAs in CAC, and their roles in genes’ expression modulation in chronic colonic-inflammation-induced carcinogenesis, including programmed cell-death pathways. These miRNAs dysregulation could be applied for early CAC diagnosis, to predict therapy efficacy and for precision treatment. 相似文献
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The notion of pseudorandomness is the theoretical foundation on which to consider the soundness of a basic structure used in some block ciphers. We examine the pseudorandomness of the block cipher KASUMI, which will be used in the next‐generation cellular phones. First, we prove that the four‐round unbalanced MISTY‐type transformation is pseudorandom in order to illustrate the pseudorandomness of the inside round function FI of KASUMI under an adaptive distinguisher model. Second, we show that the three‐round KASUMI‐like structure is not pseudorandom but the four‐round KASUMI‐like structure is pseudorandom under a non‐adaptive distinguisher model. 相似文献
4.
The PBD-Closure of Constant-Composition Codes 总被引:3,自引:0,他引:3
Yeow Meng Chee Ling A.C.H. San Ling Hao Shen 《IEEE transactions on information theory / Professional Technical Group on Information Theory》2007,53(8):2685-2692
We show an interesting pairwise balanced design (PBD)-closure result for the set of lengths of constant-composition codes whose distance and size meet certain conditions. A consequence of this PBD-closure result is that the size of optimal constant-composition codes can be determined for infinite families of parameter sets from just a single example of an optimal code. As an application, the sizes of several infinite families of optimal constant-composition codes are derived. In particular, the problem of determining the size of optimal constant-composition codes having distance four and weight three is solved for all lengths sufficiently large. This problem was previously unresolved for odd lengths, except for lengths seven and eleven. 相似文献
5.
用Nardini-Brebbia边界元法计算了动载荷下的应力强度因子,与解析解及有限元解相比较,效果较好。最后对计算结果进行了分析讨论。 相似文献
6.
Spatial bound whale optimization algorithm: an efficient high-dimensional feature selection approach
Too Jingwei Mafarja Majdi Mirjalili Seyedali 《Neural computing & applications》2021,33(23):16229-16250
Neural Computing and Applications - Selecting a subset of candidate features is one of the important steps in the data mining process. The ultimate goal of feature selection is to select an optimal... 相似文献
7.
Chee -Keng Yap 《Algorithmica》1988,3(1-4):279-288
We give a parallel method for triangulating a simple polygon by two (parallel) calls to the trapezoidal map computation. The method is simpler and more elegant than previous methods. Along the way we obtain an interesting partition of one-sided monotone polygons. Using the best-known trapezoidal map algorithm, ours run in timeO(logn) usingO(n) CREW PRAM processors. 相似文献
8.
Kin Kit Fong Inn Shi Tan Henry Chee Yew Foo Man Kee Lam Adrian Chiong Yuh Tiong Steven Lim 《中国化学工程学报》2021,33(5):297-305
The rising production of produced water from oilfields had been proven to bring detrimental environmental effects. In this study, an efficient, recyclable, and environmental-friendly reduced graphene oxide immobilized κ-Carrageenan hydrogel composite(κCa GO) was fabricated as an alternative sorbent for crude oil-in-water demulsification. Polyethyleneimine(PEI) was employed to form a stable hydrogel composite. The conditions for the immobilization of graphene oxide(GO) on PEI-modified κ-Carrageenan(κC) beads were optimized appropriately. An immobilization yield of 77% was attained at 2% PEI, 2 h immobilization activation time, and p H6.5. Moreover, the synthesized κCa GO is capable of demulsification with an average demulsification efficiency of 70%. It was found that the demulsification efficiency increases with salinity and κCa GO dosage, and it deteriorates under alkaline condition. These phenomena can be attributed to the interfacial interactions between κCa GO and the emulsion. Furthermore, the κCa GO can be recycled to use for up to six cycles without significant leaching and degradation. As such, the synthesized κCa GO could be further developed as a potential sorbent substitute for the separation of crude oil from produced water. 相似文献
9.
A simple method was developed for estimating the particle diffusivity or mixing coefficient in a liquid-solids fluidized bed from the variance (dispersion) of the number of particles in a given section of the bed during relaxation in the bed expansion. This variance was estimated from the pressure drop history above the location of the pressure sensor recorded continuously after the stepwise disturbance in the velocity of the fluidizing medium. The method has been verified by comparing the particle diffusivities obtained by the present method with the available data obtained by other methods. 相似文献
10.
The applicability of multivariate statistics to the analysis of mixing processes and mixtures of multicomponent solid particles in a drum mixer has been successfully demonstrated. The applications include (1) test of sampling techniques, (2) test of the completely random state, (3) test of the completely segregated state, and (4) definition of a mixing index for a multicomponent mixture. 相似文献