Microfluidic device for continuous magnetophoretic separation of white blood cells

This paper presents a microfluidic device for magnetophoretic separation of red blood cells from blood under continuous flow. The separation method consists of continuous flow of a blood sample (diluted in PBS) through a microfluidic channel which presents on the bottom “dots” of ferromagnetic layer. By applying a magnetic field perpendicular on the flowing direction, the ferromagnetic “dots” generate a gradient of magnetic field which amplifies the magnetic force. As a result, the red blood cells are captured on the bottom of the microfluidic channel while the rest of the blood is collected at the outlet. Experimental results show that an average of 95% of red blood cells is trapped in the device.     

A PC-Based Simulator/Controller/Monitor Software for a Generic 6-DOF Manipulator

General form application is a very important issue in industrial design. Prototyping a design helps in determining system parameters, ranges and in structuring better systems. Robotics is one of the industrial design fields in which prototyping is crucial for improved functionality. Developing an environment that enables optimal and flexible design using reconfigurable links, joints, actuators and sensors is essential for using robots in the education and industrial fields. We propose a PC-based software package to control, monitor, and simulate a generic 6-DOF (six degrees of freedom) robot including a spherical wrist. This package may be used as a black box for the design implementations or as a white (detailed) box for learning about the basics of robotics and simulation technology.     

Malware clustering using suffix trees

Clustering is an important problem in malware research, as the number of malicious samples that appear every day makes manual analysis impractical. Although these samples belong to a limited number of malware families, it is difficult to categorize them automatically as obfuscation is involved. By extracting relevant features we can apply clustering algorithms, then only analyze a couple of representatives from each cluster. However, classic clustering algorithms that compute the similarity between each pair of samples are slow when a large collection is involved. In this paper, the features will be strings of operation codes extracted from the binary code of each sample. With a modified suffix tree data structure we can find long enough substrings that correspond to portions of a program’s code. These substrings must be filtered against a database of known substrings so that common library code will be ignored. The items that have common substrings above a certain threshold will be grouped into the same cluster. Our algorithm was tested with data extracted from real-world malware and constructed quality clusters.     

Osteonecrosis of the Jaws in Patients with Hereditary Thrombophilia/Hypofibrinolysis—From Pathophysiology to Therapeutic Implications

Osteonecrosis of the jaws (ONJ) usually has a clear etiology. Local infection or trauma, radiotherapy and drugs that disrupt the vascular supply or bone turnover in the jaws are its major contributors. The thrombotic occlusion of the bone’s venous outflow that occurs in individuals with hereditary thrombophilia and/or hypofibrinolysis has a less known impact on jaw health and healing capability. Our research provides the most comprehensive, up-to-date and systematized information on the prevalence and significance of hereditary thrombophilia and/or hypofibrinolysis states in ONJ. We found that hereditary prothrombotic abnormalities are common in patients with ONJ refractory to conventional medical and dental treatments. Thrombophilia traits usually coexist with hypofibrinolysis traits. We also found that frequently acquired prothrombotic abnormalities coexist with hereditary ones and enhance their negative effect on the bone. Therefore, we recommend a personalized therapeutic approach that addresses, in particular, the modifiable risk factors of ONJ. Patients will have clear benefits, as they will be relieved of persistent pain and repeated dental procedures.     

Cell therapy using an array of ultrathin hollow microneedles

Microsystem Technologies - Cell transplantation traditionally employs needles to inject donor cells into tissues to treat certain diseases. However, it is difficult for the current method to...     

Using contexts and R-R interval estimation in lossless ECG compression

The paper presents a new lossless ECG compression scheme. The short-term predictor and the coder use conditioning on a small number of contexts. The long-term prediction is based on an algorithm for R-R interval estimation. Several QRS detection algorithms are investigated to select a low complexity and reliable detection algorithm. The coding of prediction residuals uses primarily the Golomb-Rice (GR) codes, but, to improve the coding results, escape codes GR-ESC are used in some contexts for a limited number of samples. Experimental results indicate the good overall performance of the lossless ECG compression algorithms (reducing the storage needs from 12 to about 3-4 bits per sample). The scheme consistently outperforms other waveform or general purpose coding algorithms.     

A dielectrophoretic chip packaged at wafer level

The paper presents a dielectrophoretic chip, fully enclosed, with bulk silicon electrodes fabricated using wafer-to-wafer bonding techniques and packaged at the wafer level. The silicon electrodes, which are bonded to two glass dies, define in the same time the walls of the microfluidic channel. The device is fabricated from a silicon wafer that is bonded (at wafer level) anodically and using SU8 photoresist between two glass wafers. The first glass die includes drilled holes for inlet/outlet connections while the second glass die assure the electrical connections, through via holes and a metallization layer, between the silicon electrodes and a printing circuit board.     

Defect-free wet etching through pyrex glass using Cr/Au mask

This paper reports the highest etch depth of annealed Pyrex glass achieved by wet etching in highly concentrated HF solution, using a low stress chromium–gold with assistance of photoresist as masking layer. The strategies to achieve that are: increasing the etch rate of glass and simultaneously increasing the resistance of Cr/Au mask in the etchant. By annealing the Pyrex glass and using a highly concentrated HF acid, a high etch rate can be obtained. Furthermore, a method to achieve a good resistance of the Cr/Au masking layer in the etching solution is to control the residual stress and to increase the thickness of Au deposition up to 1 μm. In addition, the presence of a hard baked photoresist can improve the etching performance. As a result, a 500-μm thick Pyrex glass wafer was etched through.

     

On the connection between the exponential stability of C0-semigroups and the admissibility of a certain Sobolev space

Let T be a strongly continuous semigroup on a Banach space X and A its infinitesimal generator. We will prove that T is exponentially stable, if and only if, there exist p[1,∞) such that the space is admissible to the system Σ(A,I,I), defined below (i.e for all f belonging to the Sobolev space the convolution T*f lies in .