Infrared heated μ-blistering,a new fabrication technology for HARMST

Polymeric replication technologies such as injection moulding or hot-embossing have gained wide acceptance in the microtechnological community, microthermoforming of thin polymer foils, also called μ-blistering, still remains relatively unknown. Although the general potentials of the µ-blistering have already been pointed out, little work has been carried out addressing its capability for high aspect ratio microstructuring. In the scope of this work we therefore demonstrate the feasibility of μ-blistering to obtain aspect ratios for free standing structures of up to 7 within a process cycle time of <4 min. The presented processing technology uniquely combines manufacturing of macro-, micro- and even nanoscopic feature sizes in a single process.     

Integrationsdefizite des IT-Controllings

Zusammenfassung  Der Beitrag basiert auf der Annahme, dass das IT-Controlling in zweifacher Hinsicht unter einem Integrationsdefizit leidet. Dies gilt zum einen für die unbefriedigende Synchronisation der Forschung mit Entwicklungen in der Praxis, zum anderen für die unzureichende Verzahnung mit den Methoden der Wirtschaftsinformatik. Ausgehend von dieser Annahme untersucht der Beitrag die historische Entwicklung des IT-Controllings, um daraus Thesen zum Integrationsstand abzuleiten. Die Untersuchung kommt zu dem Ergebnis, dass Hinweise auf – nach wie vor – ungenutzte Integrationspotenziale vorliegen und identifiziert Potenziale einer weiter gehenden Integration. Aus der Analyse identifizierter Integrationspotenziale werden Anforderungen an eine methodenbezogene Integration abgeleitet und die Realisierung von Integrationspotenzialen an zwei Beispielen illustriert. This article is also available in English via and : Strecker S, Kargl H (2009) Integration Deficits of IT Controlling – Historical Background, Analysis of Integration Potentials and Method Integration. Bus Inf Syst Eng. doi: 10.1007/s12599-009-0053-4.     

A 3D moving grid algorithm for process simulation

A moving grid algorithm is presented for simulation of 3D oxidation processes. The algorithm combines local displacement of mesh points according to material velocity and local mesh cleanup. Several examples are shown that demonstrate the capabolity to simulate both the growth of thin layers of oxide during polysilicon gate reoxidation, as well at stress dependent growth of 3D locos oxides.     

SMART-Reactors: Tailoring Gas Holdup Distribution by Additively Manufactured Lattice Structures

In chemical process engineering, fast gas-liquid reactions often suffer from an inefficient distribution of gas and therefore mixing and mass transfer performance. This study deals with the possibility of influencing the local gas holdup and bubble size distribution in a gas-liquid process using additively manufactured lattice structures (AMLS). The used measuring technique to study bubble size, velocity, and the local gas holdup is a photo-optical needle probe. By using AMLS, a significant radial homogenization of the local gas holdup and the mean bubble size is achieved. Furthermore, it can be demonstrated that the bubble size can be tailored by the geometry of the inserted structure. It is illustrated that the mean bubble velocities are lowered within the lattice resulting in a higher residence time of the dispersed phase with an impact on the mass transfer performance within the AMLS.     

Cloning and functional characterization of a new phosphatidyl-inositol anchored molecule of a metastasizing rat pancreatic tumor

We have described recently a panel of metastasis-associated antigens expressed on a rat pancreatic tumor. One of these molecules, recognized by the monoclonal antibody C4.4 and named accordingly C4.4A, was under physiological conditions expressed only in the gravid uterus and on epithelial of the upper gastrointestinal tract. The cDNA of the antigen has been isolated and cloned. The 1,637 b cDNA codes for a 352 amino acid long glycosylphosphatidyl-inositol (GP) anchored molecule, whose molecular weight varies in different cells between 94-98 kD according to the degree of N- and O-glycosylation. Data base searches have revealed a low degree of homology to the receptor for the plasminogen activator (uPAR). After intrafootpad and intravenous application of C4.4A transfected and mock-transfected tumor cells, an increased number of lung nodules was detected with the former, whereby the individual metastatic nodules amalgamated without any encapsulation of the tumor tissue. Furthermore, C4.4A is involved in adhesion to laminin and, although transfection of a non-metastasizing tumor line with the molecule was not sufficient, constitutively C4.4A-positive tumor cells penetrated through matrigel. This process could be completely prevented by C4.4. Finally, we could demonstrate that uPA, albeit weakly, bound to the C4.4A molecule. In view of the observed influence of C4.4A on metastasis formation and matrix penetration it is tempting to speculate that this newly described metastasis-associated molecule may exert functional activity similar to the uPAR, i.e. via activation of matrix degrading enzymes. By the very restricted expression of the molecule in the adult organism, modulation of C4.4A could well be of therapeutic interest.     

The maximum extent of reaction in gelled systems

Just how far reactions can go after gelation during the cure of telechelic prepolymers has been a debatable point for some time. Utilizing a recently devised method,⁷ the curing reactions of some telechelic prepolymers were followed after the gel point. Extents of reaction above 90% occurred only in systems of average functionality close to two, functionality being the average number of reactive groups per molecule. Among systems of higher functionality, maximum extents of reaction of about 70% were most common. The final extent of reaction was only a few per cent above the extent of reaction at the gel point. The maximum extent of reaction varied with the concentration of reactive species and the relationship was a linear one at each functionality of the system. The data were consistent with P_A²/r = {0.88/[(h ? 1)(j ? 1)]} + 0.10 where P_A is the fraction of prepolymer reactive groups initially present which have reacted, r is the ratio of the initial number of crosslinking groups to prepolymer reactive groups, and h and j are weighted average functionalities of the two reactants. It is suggested that the limiting factor in defining the final extent of reaction in these systems is the accessibility of reactive groups as determined by solid geometry rather than thermodynamics or reaction kinetics. The final extent of cure is regularly dependent on functionality and one cannot regard functionality and maximum extent of reaction as independent variables.     

Mechanical properties and cytotoxicity of 3Y-TZP bioceramics reinforced with Al2O3 particles

The influence of Al₂O₃ addition and sintering parameters on the mechanical properties and cytotoxicity of tetragonal ZrO₂–3 mol% Y₂O₃ ceramics was evaluated. Samples containing 0, 10, 20 and 30 wt.% of Al₂O₃ particles were prepared by cold uniaxial pressing (80 MPa) and sintered in air at 1500, 1550 and 1600 °C for 120 min. The effects of the sintering conditions on the microstructure were analyzed by X-ray diffraction analysis and scanning electron microscopy. Hardness and fracture toughness were determined by the Vickers indentation method and the mechanical resistance by four-point bending tests. As a preliminary biological evaluation, “in vitro” cytotoxicity tests were realized to determine the cytotoxic level of the ZrO₂–Al₂O₃ composites, using the neutral red uptake method with NCTC clones L929 from the American Type Culture Collection (ATCC) bank. Fully dense ceramic materials were obtained with a hardness ranging between 1340 HV and 1585 HV, depending on the amount of Al₂O₃ in the ZrO₂ matrix. On the other hand, no significant influence of the Al₂O₃ addition on fracture toughness was observed, exhibiting values near 8 MPa m^1/2 for all compositions and sintering conditions studied. The non-cytotoxic behavior, the elevated fracture toughness, the good bending strength (σ_f = 690 MPa) and the elevated Weibull's modulus (m = 11) exhibited by the material, show that these ceramic composites are highly suitable biomaterials for dental implant applications.