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1.
Lung surfactant replacement has been tested clinically in recent years. In this study the outcome of 31 premature infants with moderate to severe neonatal respiratory distress syndrome (RDS) treated with surfactant was compared to that of 74 prematures with RDS treated conventionally by positive pressure ventilation and supportive care. The groups were well matched for gestational age, birthweight, sex, and Apgar scores at 1 and 5 min. Surfactant treatment resulted in a significant decrease in mortality--from 36.6% in the untreated group to 12.9% in the surfactant-treated group (P < 0.04). This improvement in survival was seen also in prematures with a birthweight < 1,000 g; in the untreated group mortality was 57.6% compared to 23.5% in the treated group (P < 0.05). The incidence of pneumothorax was lower in the treated group--42% vs. 13% (P < 0.01). Surfactant treatment resulted in a trend of more survivors without bronchopulmonary dysplasia or intraventricular hemorrhage, even though surfactant therapy did not change the incidence of either. 相似文献
2.
Among all basic on-line load balancing problems, the only unresolved problem was load balancing of temporary tasks on unrelated machines. This open problem existed for almost a decade, see [12]. We resolve this problem by providing an inapproximability result. In addition, a newer open question is to identify the dependency of the competitive ratio on the durations of jobs in the case where durations are known. We resolve this problem by characterizing this dependency. Finally, we provide a PTAS for the off-line problem with a fixed number of machines and show a 2 -inapproximability result for the general case. 相似文献
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We provide combinatorial algorithms for the unsplittable flow problem (UFP) that either match
or improve the previously best results. In the UFP we are given a (possibly directed) capacitated graph with n vertices and
m edges, and a set of terminal pairs each with its own demand and profit. The objective is to connect a subset of the terminal
pairs each by a single flow path subject to the capacity constraints such that the total profit of the connected pairs is
maximized.We consider three variants of the problem. First is the classical UFP in which the maximum demand is at most the
minimum edge capacity. It was previously known to have an O(√m) approximation algorithm; the algorithm is based on the randomized
rounding technique and its analysis makes use of the Chernoff bound and the FKG inequality.We provide a combinatorial algorithm
that achieves the same approximation ratio and whose analysis is considerably simpler. Second is the extended UFP in which
some demands might be higher than edge capacities. Our algorithm for this case improves the best known approximation ratio.
We also give a lower bound that shows that the extended UFP is provably harder than the classical UFP. Finally, we consider
the bounded UFP in which the maximum demand is at most 1/K times the minimum edge capacity for some K > 1. Here we provide
combinatorial algorithms that match the currently best known algorithms. All of our algorithms are strongly polynomial and
some can even be used in the online setting. 相似文献
5.
The void coefficients in tight water lattices with enriched plutonium fuel were calculated. It was found that for the same fuel, the void coefficient is negative when the moderator is light water and positive when the moderator is heavy water. The explanation to this presumed anomally is given. 相似文献
6.
Creep properties of specimens taken from the core of AZ91D magnesium alloy ingots (9 pct Al, 1 pct Zn) were examined in the
temperature range of 120 °C to 180 °C and stress range of 40 to 115 MPa. Solution-treated and aged creep specimens were also
tested. The creep rates observed were about three orders of magnitude lower than those of pure magnesium, and elongations
to fracture were seen to be at least twice those of pure magnesium. A minimum creep rate was reached after approximately 2/3
of the creep life of the specimens (except for the aged specimens, in which the minimum creep rate appears at the beginning
of the test). A qualitative model for the creep process in proposed on the basis of the creep tests and optical, scanning
electron, and transmission electron microscopy. This model proposes that dislocation motion on additional slip systems is
the primary creep mechanism and that cracking acts as a stress relief mechanism. Structural instability dictates the amount
of hardening and, hence, creep resistance. 相似文献
7.
Hartl Tamara L.; Zeiss Robert A.; Marino Catherine M.; Zeiss Antonette M.; Regev Lisa G.; Leontis Carrie 《Canadian Metallurgical Quarterly》2007,38(6):674
Sexually inappropriate behaviors in clinical settings are relatively common occurrences that may negatively affect the therapeutic process. For example, more than half of female psychologists have reported at least 1 incident in which a client responded in a sexually inappropriate manner. Thus, it is important for clinicians to understand inappropriate behaviors and respond in a manner that is both personally satisfying and helpful to the client. A framework for conceptualizing these behaviors is proposed, as well as components for, and examples of, therapeutic responses. Recommendations are provided for preventive measures to decrease the likelihood of inappropriate behaviors and for systemic approaches to benefit professional training in regards to these issues. Our aim is to stimulate further discussion of sexually inappropriate behaviors specifically by facilitating psychotherapists' ability to address clients' within-session sexual behavior, facilitating speculation of the antecedents of and motivations behind such behaviors, and facilitating discussion of such behaviors within supervision and, more broadly, within training programs. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
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Danielle Regev Sharon Etzion Hen Haddad Jacob Gopas Aviv Goldbart 《International journal of molecular sciences》2022,23(18)
Cardiovascular morbidity is the leading cause of death of obstructive sleep apnea (OSA) syndrome patients. Nocturnal airway obstruction is associated with intermittent hypoxia (IH). In our previous work with cell lines, incubation with sera from OSA patients induced changes in cell morphology, NF-κB activation and decreased viability. A decrease in beating rate, contraction amplitude and a reduction in intracellular calcium signaling was also observed in human cardiomyocytes differentiated from human embryonic stem cells (hESC-CMs). We expanded these observations using a new controlled IH in vitro system on beating hESC-CMs. The Oxy-Cycler system was programed to generate IH cycles. Following IH, we detected the activation of Hif-1α as an indicator of hypoxia and nuclear NF-κB p65 and p50 subunits, representing pro-inflammatory activity. We also detected the secretion of inflammatory cytokines, such as MIF, PAI-1, MCP-1 and CXCL1, and demonstrated a decrease in beating rate of hESC-CMs following IH. IH induces the co-activation of inflammatory features together with cardiomyocyte alterations which are consistent with myocardial damage in OSA. This study provides an innovative approach for in vitro studies of OSA cardiovascular morbidity and supports the search for new pharmacological agents and molecular targets to improve diagnosis and treatment of patients. 相似文献