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1.
The paper presents an improved e-learner model that supports monitoring of user behavior related to information security. The model is built upon standardized IMS specification, according to literature research and survey conducted among e-learners. It is positioned as key part of an extended LTSA architecture in which the learner data is used to improve learner security position by continuous delivery of important information and adapting security mechanisms. The implementation is considered in Moodle LMS. 相似文献
2.
Barbara Sita Mihaela Bobi-Rasonja Goran Mrak Sara Trnski Magdalena Krbot Skori Darko Orekovi Vinka Knezovi
eljka Petelin Gade Zdravko Petanjek Goran imi Danijela Kolenc Nataa Jovanov Miloevi 《International journal of molecular sciences》2022,23(15)
The extracellular matrix (ECM) is an important regulator of excitability and synaptic plasticity, especially in its highly condensed form, the perineuronal nets (PNN). In patients with drug-resistant mesial temporal lobe epilepsy (MTLE), hippocampal sclerosis type 1 (HS1) is the most common histopathological finding. This study aimed to evaluate the ECM profile of HS1 in surgically treated drug-resistant patients with MTLE in correlation to clinical findings. Hippocampal sections were immunohistochemically stained for aggrecan, neurocan, versican, chondroitin-sulfate (CS56), fibronectin, Wisteria floribunda agglutinin (WFA), a nuclear neuronal marker (NeuN), parvalbumin (PV), and glial-fibrillary-acidic-protein (GFAP). In HS1, besides the reduced number of neurons and astrogliosis, we found a significantly changed expression pattern of versican, neurocan, aggrecan, WFA-specific glycosylation, and a reduced number of PNNs. Patients with a lower number of epileptic episodes had a less intense diffuse WFA staining in Cornu Ammonis (CA) fields. Our findings suggest that PNN reduction, changed ECM protein, and glycosylation expression pattern in HS1 might be involved in the pathogenesis and persistence of drug-resistant MTLE by contributing to the increase of CA pyramidal neurons’ excitability. This research corroborates the validity of ECM molecules and their modulators as a potential target for the development of new therapeutic approaches to drug-resistant epilepsy. 相似文献
3.
Višnja Katalinić Sonja Smole Možina Danijela Skroza Ivana Generalić Helena Abramovič Mladen Miloš Ivica Ljubenkov Saša Piskernik Ivan Pezo Petra Terpinc Mladen Boban 《Food chemistry》2010
The aim of the present study was to determine polyphenolic composition, related antioxidative and antimicrobial properties of grape skin extracts from 14 grape varieties (seven white and seven red grape) grown in Dalmatia (Croatia). The content of total phenols, flavonoids, catechins, flavanols and individual polyphenols ((+)-catechin, (−)-epicatechin, epicatechin gallate, procyanidin B1 and procyanidin B2, quercetin glucoside, resveratrol monomers, piceid and astringin) was variety dependent. Antioxidant properties were determined as DPPH radical-scavenging ability (IC50), ferric reducing/antioxidant power (FRAP), Fe2+-chelating activity (IC50), and using β-carotene bleaching assay. The high antioxidant capacity of all extracts, both red and white, has been observed and related to the relative amounts of polyphenolic compounds with good antioxidant properties. The antimicrobial activity was screened by broth microdilution test using Gram-positive (Staphylococcus aureus, Bacillus cereus) and Gram-negative bacteria (Escherichia coli O157:H7, Salmonella Infantis, Campylobacter coli). It was confirmed against all tested organisms. Minimum inhibitory concentrations (MICs), were found in the range 0.014–0.59 mg of gallic acid equivalents (GAE)/ml, with lower MICs of white cultivars, especially against Campylobacter and Salmonella. 相似文献
4.
Ivana Tomaz Luna Maslov Domagoj Stupić Darko Preiner Danijela Ašperger Jasminka Karoglan Kontić 《分离科学与技术》2016,51(2):255-268
Grape skin contains large amounts of different flavonoids so it can be used for their recovery. Optimization of enzyme-assisted extraction of flavonoids was conducted using oenological enzyme preparations with respect to enzyme dosage, temperature, extraction time, pH, and enzyme preparation. Optimal conditions were obtained using enzyme preparation Lallzyme EX-V, at the temperature of 45°C, time of 3 h, pH 2.0, and enzyme dosage of 10.52 mg/g. The new optimized extraction method is less expensive, simple, accurate, and selective for the recovery of simple flavonoids. It is based on an environmentally-friendly extraction solvent which may provide a valuable alternative to conventional methods. 相似文献
5.
Danijela?D.?MaksinEmail author Radmila?V.?Hercigonja Magdalena??.?Lazarevi? Marija?J.??uni? Aleksandra?B.?Nastasovi? 《Polymer Bulletin》2012,68(2):507-528
Technetium-99 comprises a significant health risk, since edible plants can bioaccumulate and convert it to more lipophilic
species that cannot be excreted through urine. Batch kinetics of pertechnetate removal from aqueous solutions by two samples
of crosslinked poly(glycidyl methacrylate-co-ethylene glycol dimethacrylate) functionalized with diethylene triamine (PGME-deta) was investigated at the optimum pH value
of 3.0, and the initial solution activity of 325 MBq dm−3. PGME-deta was characterized by elemental analysis, mercury intrusion porosimetry, and scanning electron microscopy. Five
kinetic models (pseudo-first, pseudo-second order, Elovich, Bangham, and intraparticle diffusion) were used to determine the
best-fit equation for pertechnetate sorption. After 24 h, PGME-deta samples sorbed more than 98% of pertechnetate present,
with maximum sorption capacity of 25.5 MBq g−1, showing good potential for remediation of slightly contaminated groundwater. 相似文献
6.
Dr. Robert Kuhnert Dr. Lydia Kuhnert Dr. Menyhárt-B. Sárosi Sven George Dr. Dijana Draca Dr. Svetlana Paskas Dr. Bettina Hofmann Prof. Dr. Dieter Steinhilber Prof. Dr. Walther Honscha Prof. Dr. Sanja Mijatović Prof. Dr. Danijela Maksimović-Ivanić Prof. Dr. Evamarie Hey-Hawkins 《ChemMedChem》2022,17(1):e202100588
12-Lipoxygenase is crucial for tumour angiogenesis. 5,6,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one (baicalein) is a suitable inhibitor for this enzyme but is rapidly metabolised in vivo. Thus, an improvement of the metabolic stability is necessary to enhance the therapeutic efficiency. An emerging approach to enhance metabolic stability of carbon-based pharmaceuticals is the use of metabolically stable, non-toxic boron clusters, such as dicarba-closo-dodecaborane(12)s (carboranes) as phenyl mimetics. Therefore, the unsubstituted phenyl ring of baicalein was replaced by meta-carborane, resulting in borcalein, the carborane analogue of baicalein. This substitution resulted in a decreased inhibitory activity toward 12-lipoxygenase, but led to increased toxicity in melanoma (A375, B16, B16F10) and colon cancer cell lines (SW480, HCT116, CT26CL25) with decreased tumour selectivity in comparison to baicalein. Surprisingly, borcalein displays a different mechanism of cytotoxicity with increased intracellular production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and nitric oxide (NO). 相似文献
7.
Zoran Mandinic Marijana Curcic Momir Carevic Danijela Djukic-Cosic 《The Science of the total environment》2010,408(17):3507-3512
In this study we determined the fluoride content in drinking water and hair of 12-year-old schoolchildren from different Serbian municipalities, i.e. Valjevo, Veliko Gradiste, Kacarevo and Vranjska Banja. The analyses were performed using composite fluoride ion-selective electrode. Average fluoride levels were 0.10, 0.15, 0.79 and 11 ppm in well water, 0.07, 0.10, 0.17 and 0.15 ppm in tap water, 19.3, 21.5, 25.4, and 32.5 ppm in hair samples, in Valjevo, Veliko Gradiste, Kacarevo and Vranjska Banja, respectively. Correlation analysis indicated statistically significant positive relationship between fluoride in wells water and fluoride in hair, for all municipalities: correlation coefficients were 0.54 (p < 0.05), 0.89, 0.97 and 0.99 (p < 0.001), in Vranjska Banja, Valjevo, Veliko Gradiste, and Kacarevo, respectively. Positive correlation was obtained also between fluoride in tap water and hair samples in all regions under the study, with statistical significance only in Valjevo municipality, p < 0.05. Dental examination of schoolchildren confirmed dental fluorosis only in the region of Vranjska Banja. Moreover, in endemic fluorotic region of Vranjska Banja, positive and statistically significant correlations were confirmed between fluoride in well water and dental fluorosis level (r = 0.61; p < 0.01) and additionally between fluoride in hair and dental fluorosis level (0.62; p < 0.01). The primary findings from this study have shown that fluoride content in hair is highly correlated with fluoride content in drinking water and dental fluorosis level, indicating that hair may be regarded as biomaterial of high informative potential in evaluating prolonged exposure to fluorides and to individuate children at risk of fluorosis regardless of the phase of teeth eruption. 相似文献
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Verica Dragovic-Uzelac Branka LevajVlatka Mrkic Danijela BursacMarija Boras 《Food chemistry》2007,102(3):966-975
During the ripening of three apricot cultivars (“Keckemetska ruza”, “Madjarska najbolja” and “Velika rana”) grown in two different geographical region of Croatia the changes of polyphenols and carotenoids were determined by using high-performance liquid chromatography (HPLC) with UV–Vis photo diode array detection. The content of individual polyphenols during ripening was quite similar, whereas their amount differed significantly. Immature fruits showed the highest level of polyphenols, which decreased at semi-mature fruits and did not change remarkably in commercial mature fruits. Among polyphenols, flavan-3-ols, chlorogenic acid and quercetin-3-rutinoside were dominant in all ripening stages of all apricot cultivars. The quantity of polyphenols during apricot fruits ripening depended on cultivars, while the region of cultivation did not have remarkable influence on polyphenols amount. During ripening carotenoids increased significantly especially β-carotene which represented 70–85% of the total carotenoid content. Besides β-carotene, in all apricot cultivars γ-carotene was found. α-Carotene, zeaxantin and lutein were found in cv. “Madjarska najbolja” and in cv. “Velika rana” α-carotene and lutein were determined. The region of cultivation and the cultivar were important factors, which influenced the carotenoid amount of apricot fruits, and this content was higher in cultivars grown in Mediterranean region. 相似文献
10.
Anticancer Potential of (Pentamethylcyclopentadienyl)chloridoiridium(III) Complexes Bearing κP and κP,κS‐Coordinated Ph2PCH2CH2CH2S(O)xPh (x=0–2) Ligands 下载免费PDF全文
Gerd Ludwig Ivan Ranđelović Dr. Danijela Maksimović‐Ivanić Dr. Sanja Mijatović Mirna Z. Bulatović Dr. Djordje Miljković Prof. Marcus Korb Prof. Dr. Heinrich Lang Prof. Dr. Dirk Steinborn Prof. Dr. Goran N. Kaluđerović 《ChemMedChem》2014,9(7):1586-1593
Iridium(III) complexes of the type [Ir(η5‐C5Me5)Cl2{Ph2PCH2CH2CH2S(O)xPh‐κP}] (x=0–2; 1 – 3 ) and [Ir(η5‐C5Me5)Cl{Ph2PCH2CH2CH2S(O)xPh‐κP,κS}][PF6] (x=0–1; 4 and 5 ) with 3‐(diphenylphosphino)propyl phenyl sulfide, sulfoxide, and sulfone ligands Ph2PCH2CH2CH2S(O)xPh were designed, synthesized, and characterized fully, including X‐ray diffraction analyses for complexes 3 and 4 . In vitro studies against human thyroid carcinoma (8505C), submandibular carcinoma (A253), breast adenocarcinoma (MCF‐7), colon adenocarcinoma (SW480), and melanoma (518A2) cell lines provided evidence for the high biological potential of the neutral and cationic iridium(III) complexes. Neutral iridium(III) complex 5 proved to be the most active, with IC50 values up to about 0.1 μM , representing activities of up to one order of magnitude higher than cisplatin. Using 8505C cells, apoptosis was shown to be the main mechanism through which complex 5 exerts its tumoricidal action. The described iridium(III) complexes represent potential leads in the search for novel metal‐based anticancer agents. 相似文献