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排序方式: 共有474条查询结果,搜索用时 15 毫秒
1.
Karolina M. Wójciak Dariusz M. Stasiak Joanna Stadnik Karolina Ferysiuk Anna Kononiuk 《International Journal of Food Science & Technology》2019,54(1):75-83
In this study, the influence of sonication time on the biogenic amines formation as a critical point in uncured dry-fermented beef manufacturing was studied. Samples of musculus semimembranosus were sonicated at different times (5 and 10 min) using ultrasound cold bath (4 °C) in acid whey (US 40 kHz and acoustic power 480 W). The effect of sonication on biogenic amine (BA) formation was investigated during 93 days of ripening period. Other parameters (pH value, water activity, microbial counts) that might provide further information on the product under study were also determined. The use of ultrasound during beef marinating in acid whey has a positive effect on retarding histamine (HIS), cadaverine (CAD), tyramine (TYR) and putrescine (PUT) formation. Moreover, the sonication treatment did not inhibit the growth of lactic acid bacteria (LAB) in dry-fermented beef during the whole ripening period. The pathogen bacteria (Staphylococcus aureus, Clostridium sp., Listeria monocytogenes) were not detected in all samples neither after 31 nor after 93 days of ripening period. 相似文献
2.
Jan Korbecki Klaudyna Kojder Patrycja Kapczuk Patrycja Kupnicka Barbara Gawroska-Szklarz Izabela Gutowska Dariusz Chlubek Irena Baranowska-Bosiacka 《International journal of molecular sciences》2021,22(2)
Hypoxia is an integral component of the tumor microenvironment. Either as chronic or cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible factor-1 (HIF-1) and nuclear factor (NF-κB), with cycling hypoxia showing a stronger proinflammatory influence. One of the systems affected by hypoxia is the CXC chemokine system. This paper reviews all available information on hypoxia-induced changes in the expression of all CXC chemokines (CXCL1, CXCL2, CXCL3, CXCL4, CXCL5, CXCL6, CXCL7, CXCL8 (IL-8), CXCL9, CXCL10, CXCL11, CXCL12 (SDF-1), CXCL13, CXCL14, CXCL15, CXCL16, CXCL17) as well as CXC chemokine receptors—CXCR1, CXCR2, CXCR3, CXCR4, CXCR5, CXCR6, CXCR7 and CXCR8. First, we present basic information on the effect of these chemoattractant cytokines on cancer processes. We then discuss the effect of hypoxia-induced changes on CXC chemokine expression on the angiogenesis, lymphangiogenesis and recruitment of various cells to the tumor niche, including myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), regulatory T cells (Tregs) and tumor-infiltrating lymphocytes (TILs). Finally, the review summarizes data on the use of drugs targeting the CXC chemokine system in cancer therapies. 相似文献
3.
Katarzyna Romanowska-Prchnicka Anna Felis-Giemza Marzena Olesiska Piotr Wojdasiewicz Agnieszka Paradowska-Gorycka Dariusz Szukiewicz 《International journal of molecular sciences》2021,22(6)
Tumor necrosis factor-alpha (TNF-α) is a multifunctional Th1 cytokine and one of the most important inflammatory cytokines. In pregnancy, TNF-α influences hormone synthesis, placental architecture, and embryonic development. It was also shown that increased levels of TNF-α are associated with pregnancy loss and preeclampsia. Increased TNF-α levels in complicated pregnancy draw attention to trophoblast biology, especially migratory activity, syncytialisation, and endocrine function. Additionally, elevated TNF-α levels may affect the maternal-fetal relationship by altering the secretory profile of placental immunomodulatory factors, which in turn affects maternal immune cells. There is growing evidence that metabolic/pro-inflammatory cytokines can program early placental functions and growth in the first trimester of pregnancy. Furthermore, early pregnancy placenta has a direct impact on fetal development and maternal immune system diseases that release inflammatory (e.g., TNF-α) and immunomodulatory factors, such as chronic inflammatory rheumatic, gastroenterological, or dermatological diseases, and may result in an abnormal release of cytokines and chemokines in syncytiotrophoblasts. Pregnancy poses a challenge in the treatment of chronic disease in patients who plan to have children. The activity of the disease, the impact of pregnancy on the course of the disease, and the safety of pharmacotherapy, including anti-rheumatic agents, in pregnancy should be considered. 相似文献
4.
Wioletta Rozpdek-Kamiska Grzegorz Galita Natalia Siwecka Steven L. Carroll John Alan Diehl Ewa Kucharska Dariusz Pytel Ireneusz Majsterek 《International journal of molecular sciences》2021,22(9)
Primary open-angle glaucoma (POAG) constitutes the most common type of glaucoma. Emerging evidence suggests that Endoplasmic Reticulum (ER) stress and the protein kinase RNA-like endoplasmic reticulum kinase (PERK)-mediated Unfolded Protein Response (UPR) signaling pathway play a key role in POAG pathogenesis. Thus, the main aim of the study was to evaluate the effectiveness of the PERK inhibitor LDN-0060609 in cellular model of glaucoma using primary human trabecular meshwork (HTM) cells. To evaluate the level of the ER stress marker proteins, Western blotting and TaqMan gene expression assay were used. The cytotoxicity was measured by XTT, LDH assays and Giemsa staining, whereas genotoxicity via comet assay. Changes in cell morphology were assessed by phase-contrast microscopy. Analysis of apoptosis was performed by caspase-3 assay and flow cytometry (FC), whereas cell cycle progression by FC. The results obtained have demonstrated that LDN-0060609 triggered a significant decrease of ER stress marker proteins within HTM cells with induced ER stress conditions. Moreover, LDN-0060609 effectively increased viability, reduced DNA damage, increased proliferation, restored normal morphology, reduced apoptosis and restored normal cell cycle distribution of HTM cells with induced ER stress conditions. Thereby, PERK inhibitors, such as LDN-0060609, may provide an innovative, ground-breaking treatment strategy against POAG. 相似文献
5.
Ewa ya Katarzyna Dziendzikowska Dariusz Kamola Jacek Wilczak Rafa Sapierzyski Joanna Harasym Joanna Gromadzka-Ostrowska 《International journal of molecular sciences》2021,22(9)
Background: The incidence of Crohn’s disease (CD) is increasing worldwide, and it has currently become a serious public health issue in society. The treatment of CD continues throughout a patient’s lifetime, and therefore, it is necessary to develop new, effective treatment methods, including dietotherapy. The present study aimed to determine the effects of consumption of oat beta-glucans with different molar mass on colon inflammation (colitis) in the early stages of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced CD in an animal model. Methods: Sprague–Dawley rats (control and TNBS-induced CD) were divided into three dietary groups and fed for 3 days (reflecting acute inflammation) or 7 days (reflecting remission) with a feed containing 1% low (βGl) or high (βGh) molar mass oat beta-glucan or a feed without this polysaccharide. The level of colon inflammatory markers and the expression of cytokines and their receptor genes were measured by ELISA and RT-PCR methods, respectively. Results: Acute inflammation or remission (3 or 7 days after TNBS administration, respectively) stages of experimentally induced CD were characterized by an increase in the level of inflammatory markers (IL-1, IL-6, IL-10, IL-12, TNF-α, CRP, MPO, COX, and PGE2) and the disruption of some cytokine signaling pathways as well as macro- and microscopic changes of colon tissue. The consumption of oat beta-glucans reduced the level of inflammatory markers and recovered the signaling pathways and histological changes, with stronger effects of βGl after 7 days of colitis. Conclusions: Dietary oat beta-glucans can reduce colitis at the molecular and organ level and accelerate CD remission. 相似文献
6.
Microstructure and Mechanical Properties of the Ductile Al–Ti–Mo–Nb–V Refractory High Entropy Alloys
Cieślak Grzegorz Dąbrowa Juliusz Jawańska Monika Parzuchowska Agnieszka Oleszak Dariusz 《Metallurgical and Materials Transactions A》2022,53(2):653-662
Metallurgical and Materials Transactions A - A number of non-equimolar refractory high entropy alloys (RF HEAs) from the Al–Ti–Mo–Nb–V system are synthesized, with the... 相似文献
7.
The paper addresses the problem of multi-slot just-in-time scheduling. Unlike the existing literature on this subject, it
studies a more general criterion—the minimization of the schedule makespan rather than the minimization of the number of slots
used by schedule. It gives an O(nlog 2
n)-time optimization algorithm for the single machine problem. For arbitrary number of m>1 identical parallel machines it presents an O(nlog n)-time optimization algorithm for the case when the processing time of each job does not exceed its due date. For the general
case on m>1 machines, it proposes a polynomial time constant factor approximation algorithm. 相似文献
8.
We consider deterministic distributed broadcasting on multiple access channels in the framework of adversarial queuing. Packets
are injected dynamically by an adversary that is constrained by the injection rate and the number of packets that may be injected
simultaneously; the latter we call burstiness. A protocol is stable when the number of packets in queues at the stations stays
bounded. The maximum injection rate that a protocol can handle in a stable manner is called the throughput of the protocol.
We consider adversaries of injection rate 1, that is, of one packet per round, to address the question if the maximum throughput
1 can be achieved, and if so then with what quality of service. We develop a protocol that achieves throughput 1 for any number
of stations against leaky-bucket adversaries. The protocol has
O(n2+\textburstiness){\mathcal{O}(n^2+\text{burstiness})} packets queued simultaneously at any time, where n is the number of stations; this upper bound is proved to be best possible. A protocol is called fair when each packet is
eventually broadcast. We show that no protocol can be both stable and fair for a system of at least two stations against leaky-bucket adversaries. We study in detail small systems of exactly
two and three stations against window adversaries to exhibit differences in quality of broadcast among classes of protocols.
A protocol is said to have fair latency if the waiting time of packets is
O(\textburstiness){\mathcal{O}(\text{burstiness})}. For two stations, we show that fair latency can be achieved by a full sensing protocol, while there is no stable acknowledgment
based protocol. For three stations, we show that fair latency can be achieved by a general protocol, while no full sensing
protocol can be stable. Finally, we show that protocols that either are fair or do not have the queue sizes affect the order
of transmissions cannot be stable in systems of at least four stations against window adversaries. 相似文献
9.
Marcin Bienkowski Marek Klonowski Miroslaw Korzeniowski Dariusz R. Kowalski 《Distributed Computing》2016,29(5):341-359
In this paper we consider the mutual exclusion problem on a multiple access channel. Mutual exclusion is one of the fundamental problems in distributed computing. In the classic version of this problem, n processes execute a concurrent program that occasionally triggers some of them to use shared resources, such as memory, communication channel, device, etc. The goal is to design a distributed algorithm to control entries and exits to/from the shared resource (also called a critical section), in such a way that at any time, there is at most one process accessing it. In our considerations, the shared resource is the shared communication channel itself (multiple access channel), and the main challenge arises because the channel is also the only mean of communication between these processes. We consider both the classic and a slightly weaker version of mutual exclusion, called \(\varepsilon \)-mutual-exclusion, where for each period of a process staying in the critical section the probability that there is some other process in the critical section is at most \(\varepsilon \). We show that there are channel settings, where the classic mutual exclusion is not feasible even for randomized algorithms, while the \(\varepsilon \)-mutual-exclusion is. In more relaxed channel settings, we prove an exponential gap between the makespan complexity of the classic mutual exclusion problem and its weaker \(\varepsilon \)-exclusion version. We also show how to guarantee fairness of mutual exclusion algorithms, i.e., that each process that wants to enter the critical section will eventually succeed. 相似文献
10.
We consider deterministic broadcasting in radio networks whose nodes have full topological information about the network. The aim is to design a polynomial algorithm, which, given a graph G with source s, produces a fast broadcast scheme in the radio network represented by G. The problem of finding a fastest broadcast scheme for a given graph is NP-hard, hence it is only possible to get an approximation algorithm. We give a deterministic polynomial algorithm which produces a broadcast scheme of length , for every n-node graph of diameter D, thus improving a result of Gąsieniec et al. (PODC 2005) [17] and solving a problem stated there. Unless the inclusion NP BPTIME( holds, the length of a polynomially constructible deterministic broadcast scheme is optimal.A preliminary version of this paper (with a weaker result) appeared in the Proc. 7th International Workshop on Approximation Algorithms for Combinatorial Optimization Problems (APPROX’2004), August 2004, Harvard University, Cambridge, USA, LNCS 3122, 171–182. Research of the second author supported in part by NSERC discovery grant and by the Research Chair in Distributed Computing of the Université du Québec en Outaouais. Part of this work was done during the second author’s visit at the Max-Planck-Institut für Informatik. 相似文献