Effects of the Anti-Tumorigenic Agent AT101 on Human Glioblastoma Cells in the Microenvironmental Glioma Stem Cell Niche

Glioblastoma (GBM) is a barely treatable disease due to its profound chemoresistance. A distinct inter- and intratumoral heterogeneity reflected by specialized microenvironmental niches and different tumor cell subpopulations allows GBMs to evade therapy regimens. Thus, there is an urgent need to develop alternative treatment strategies. A promising candidate for the treatment of GBMs is AT101, the R(-) enantiomer of gossypol. The present study evaluates the effects of AT101, alone or in combination with temozolomide (TMZ), in a microenvironmental glioma stem cell niche model of two GBM cell lines (U251MG and U87MG). AT101 was found to induce strong cytotoxic effects on U251MG and U87MG stem-like cells in comparison to the respective native cells. Moreover, a higher sensitivity against treatment with AT101 was observed upon incubation of native cells with a stem-like cell-conditioned medium. This higher sensitivity was reflected by a specific inhibitory influence on the p-p42/44 signaling pathway. Further, the expression of CXCR7 and the interleukin-6 receptor was significantly regulated upon these stimulatory conditions. Since tumor stem-like cells are known to mediate the development of tumor recurrences and were observed to strongly respond to the AT101 treatment, this might represent a promising approach to prevent the development of GBM recurrences.     

基于i860的存储器子系统设计

微处理机系统中的存储器子系统设计对整个系统性能的高低有重要的影响，尤其当微处理器的主频越来越高时。本文结合实际例子，给出了一个基于ｉ８６０处理器（４０ＭＨｚ）的主存设计方案，讨论了实际中需仔细考虑的因素。该设计可为其它高性能ＲＩＳＣ系统设计提供参考。     

流场拟合法在缩微环境中的研究

流场拟合法是由何继善院士提出的物理探测技术。以流场拟合法为理论基础研制的管涌渗漏检测仪在堤坝检测及抗洪抢险中发挥了重要作用，本文提出了一种在缩微环境中模拟管涌渗漏，对流场拟合法进行模拟测试并获得了明显的结果。为管涌仪器的性能检测、校验、标定提供了便捷的测试方法，并为该仪器在生产过程中统一性能和企业标准的制订提供了理论依据。     

Comprehensive meta-analysis of integrity test validities: Findings and implications for personnel selection and theories of job performance.

Conducted a comprehensive meta-analysis based on 665 validity coefficients across 576,460 data points to investigate whether integrity test validities are generalizable and to estimate differences in validity due to potential moderating influences. Results indicate that integrity test validities are substantial for predicting job performance and counterproductive behaviors on the job, such as theft, disciplinary problems, and absenteeism. The estimated mean operational predictive validity of integrity test for predicting supervisory ratings of job performance is .41. Results from predictive validity studies conducted on applicants and using external criterion measures (i.e., excluding self-reports) indicate that integrity tests predict the broad criterion of organizationally disruptive behaviors better than they predict employee theft alone. Despite the influence of moderators, integrity test validities are positive across situations and settings. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Information cut for clustering using a gradient descent approach

We introduce a new graph cut for clustering which we call the Information Cut. It is derived using Parzen windowing to estimate an information theoretic distance measure between probability density functions. We propose to optimize the Information Cut using a gradient descent-based approach. Our algorithm has several advantages compared to many other graph-based methods in terms of determining an appropriate affinity measure, computational complexity, memory requirements and coping with different data scales. We show that our method may produce clustering and image segmentation results comparable or better than the state-of-the art graph-based methods.     

Language learners' digital literacies: Focus on students' information literacy and reading practices online

The widespread use of technology and the Internet have changed many of language learners' everyday practices, including literacies. While there have been many studies with the focus on language learners' digital literacies, few, however, have explored language learners' digital information literacy and online reading practices with the use of social bookmarking tools, especially in a community college setting. We address this gap by investigating community-college language learners' digital literacies when social bookmarking with the focus on digital information and online reading practices from an ecological perspective. In this qualitative multiple-case study, the focal participants were five English learners, students in an English as a Second Language writing course in a community college in the northeastern United States. Data collection included interviews, observations, and researchers' e-journals. Thorough within- and cross-case analysis of data shows that language learners searched for digital texts and evaluated them based on relevance, reliability, interest, language, and importance for them and their learning community in the social bookmarking tool. The participants struggled with the number of results in search engines, keywords, and evaluation of digital texts for relevance and reliability. We show the need for more instruction, support, and guidance of language learners' digital information literacy practices as well as the benefits of providing students with opportunities to read digital texts. Our suggestions for future research include investigating the role of multimodality and other factors that influence language learners' evaluation practices when they look for and read information online.     

基于U-Net的多尺度融合视网膜血管分割算法

针对眼底血管图像具有形状多样、分叉较多、曲度复杂的特点,提出了一种多尺度融合视网膜血管分割算法.该算法基于U-Net模型进行改进,首先在编码和解码部分使用短跳跃连接模块将网络浅层和深层的特征信息进行融合,通过增加浅层特征的权重,更多地保留了血管的边缘和细微结构信息.其次在编码部分采用空洞卷积构建空洞空间金字塔池化模块代替传统卷积块,来扩大算法的感受野,从而在不增加网络参数的同时进行多尺度特征融合,提取更丰富的空间信息.通过在DRIVE数据集上进行验证,实验结果表明:本算法的准确率和AUC值分别达到0.9572、0.9811,与U-Net等其他基于深度学习的算法相比分割效果更优,从而验证本算法在视网膜血管分割中更加有效.     

A combo technology of autotrophic and heterotrophic denitrification processes for groundwater treatment

In this study,a sequential process (heterotrophic up-flow column and completely mixed membrane bioreactors) was proposed combining advantages of the both processes.The system was operated for 249 days with simulated and real groundwater for nitrate removal at concentrations varying from 25 to 145 mg·L-1 NO3-N.The contribution of heterotrophic process to total nitrate removal in the system was controlled by dozing the ethanol considering the nitrate concentration.By this way,sulfur based autotrophic denitrification rate was decreased and the effluent sulfate concentrations were controlled.The alkalinity requirement in the autotrophic process was produced in the heterotrophic reactor,and the system was operated without alkalinity supplementation.Throughout the study,the chemical oxygen demand in the heterotrophic reactor effluent was (23.7 ± 22) mg·L-1 and it was further decreased to(7.5 ± 7.2) mg·L-1 in the system effluent,corresponding to a 70％ reduction.In the last period of the study,the real groundwater containing 145 mg·L-1 NO3-N was completely removed.Membrane was operated without chemical washing in the first 114 days.Between days 115-249 weekly chemical washing was required.