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排序方式: 共有75条查询结果,搜索用时 15 毫秒
1.
Rodica Balasa Smaranda Maier Adina Hutanu Septimiu Voidazan Sebastian Andone Mirela Oiaga Doina Manu 《International journal of molecular sciences》2022,23(18)
Cladribine (CLD) treats multiple sclerosis (MS) by selectively and transiently depleting B and T cells with a secondary long-term reconstruction of the immune system. This study provides evidence of CLD’s immunomodulatory role in peripheral blood mononuclear cells (PBMCs) harvested from 40 patients with untreated relapsing-remitting MS (RRMS) exposed to CLD. We quantified cytokine secretion from PBMCs isolated by density gradient centrifugation with Ficoll–Paque using xMAP technology on a FlexMap 3D analyzer with a highly sensitive multiplex immunoassay kit. The PBMC secretory profile was evaluated with and without CLD exposure. PBMCs isolated from patients with RRMS for ≤12 months had significantly higher IL-4 but significantly lower IFN-γ and TNF-α secretion after CLD exposure. PBMCs isolated from patients with RRMS for >12 months had altered inflammatory ratios toward an anti-inflammatory profile and increased IL-4 but decreased TNF-α secretion after CLD exposure. CLD induced nonsignificant changes in IL-17 secretion in both RRMS groups. Our findings reaffirm CLD’s immunomodulatory effect that induces an anti-inflammatory phenotype. 相似文献
2.
Structure–property relationship of sodium deoxycholate based poly(ester ether)urethane ionomers for biomedical applications
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Daniela Filip Doina Macocinschi Stelian Vlad Gabriela Lisa Mariana Cristea Mirela F. Zaltariov 《应用聚合物科学杂志》2016,133(4)
New sodium deoxycholate based poly(ester ether)urethane ionomers were prepared for the development of biomedical materials. A structure–property relationship in the tested biomaterials was established by cross‐examination of the dynamic mechanical and dielectric properties, attenuated total reflection–Fourier transform infrared investigation, thermogravimetric analysis, and surface morphology characterization. A stronger ionic interaction and solvation capacity of the ions and a higher ionic conductivity were manifested in the case of poly(ethylene oxide)‐rich segments than for poly(propylene oxide)‐rich segments in these polyurethane ionomers. The molecular and ionic interactions of the bile‐salt moiety with different polyether cosoft segments influenced chain packing and conformation, supramolecular organization, and the resulting surface morphological microstructures of the polyurethane biomembranes. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133, 42921. 相似文献
3.
Flaviu Tma Rodica Blaa Doina Manu Gabriel Gyorki Rare Chinezu Corina Tma Adrian Blaa 《International journal of molecular sciences》2022,23(3)
Brain metastases represent more than 50% of all cerebral tumors encountered in clinical practice. Recently, there has been increased interest in the study of extracellular vesicles, and the knowledge about exosomes is constantly expanding. Exosomes are drivers for organotropic metastatic spread, playing important roles in the brain metastatic process by increasing the permeability of the blood–brain barrier and preparing the premetastatic niche. The promising results of the latest experimental studies raise the possibility of one day using exosomes for liquid biopsies or as drug carriers, contributing to early diagnosis and improving the efficacy of chemotherapy in patients with brain metastases. In this review, we attempted to summarize the latest knowledge about the role of exosomes in the brain metastatic process and future research directions for the use of exosomes in patients suffering from brain metastatic disease. 相似文献
4.
This article presents a new classification algorithm, called CLEF, which induces a -machine by constructing its own features based on the training data. The features can be viewed as defining subsets of the instance space, and they allow CLEF to create useful non-linear functions over the input variables. The algorithm is guaranteed to find a classifier that separates the training instances, if such a separation is possible. We compare CLEF empirically to several other classification algorithms, including a well-known decision tree inducer, an artificial neural network inducer, and a support vector machine inducer. Our results show that the CLEF-induced -machines and support vector machines have similar accuracy on the suite tested, and that both are significantly more accurate than the other classifiers produced. We argue that the classifiers produced by CLEF are easy to interpret, and hence may be preferred over support vector machines in certain circumstances. 相似文献
5.
Cristofor I. Simionescu Victor Bulacovschi Doina Macocinschi Gheorghe Stoica Ioan I. Neguiescu 《Polymer Bulletin》1988,19(1):59-63
Summary Suspension type PVC was reacted with sodium phenoxide in presence of different quaternary ammonium halides in THF or THF/water mixtures. The competition elimination vs. substitution of chlorine atoms depends on the homogeneity of the system, i.e. the more homogeneous the reaction mixture the less substituted the polymer.Dedicated to the 60th anniversary of Prof. Otto Vogl 相似文献
6.
Daniel MARECI Romeu CHELARIU Adrian CAILEAN Florin BRINZA Georgiana BOLAT Doina Margareta GORDIN 《中国有色金属学会会刊》2015,(1):345-353
比较了未再结晶和再结晶Ti12Mo5Ta合金、未再结晶Ti12Mo合金和工业用纯钛(cp-Ti)在0.9%生理盐水(pH 2.3)中37°C下的电化学行为。从阳极极化曲线中得到了极低的钝化电流密度(10-6 A/cm2),这表明所有样品在酸性0.9%NaCl溶液中具有高的耐蚀性能。采用扫描电子显微镜(SEM)观察样品的表面形貌,发现所有样品表面受到了相同的腐蚀,而且经阳极动电位极化测试后的样品表面没有出现点蚀、裂纹或其它缺陷。使用等效电路模拟电化学阻抗谱(EIS)数据,以表征样品表面且更好地理解Mo和Ta的添加对cp-Ti及再结晶的影响。EIS结果证实,在开路电位下,所有样品在0.9%NaCl溶液(pH 2.3)中产生钝化(极化电阻约为105Ω·cm2)。在37°C时,样品在0.9%NaCl溶液中(pH 2.3)的耐蚀性顺序为:再结晶Ti12Mo5Ta未再结晶Ti12Mo5Ta未再结晶Ti12Mocp-Ti。 相似文献
7.
Mona Cioroiu Doina Tarcau Simona Cucu-Man Maria Luca 《The Science of the total environment》2010,408(13):2639-3002
Assessment of organochlorine pesticides (OCPs) in human body is important for human health because they have weak estrogenic or antiestrogenic effects and are considered endocrine disrupters. We used colostrum of women as indicator for levels of OCPs in human body for mothers with normal and preterm labor from eastern part of Romania. Sixty- three samples of colostrum were extracted by solid-phase extraction. Analyses were carried out using gas chromatography coupled to mass spectrometry (GC-MS). OCPs have been detected in all samples, with p,p’-dichlorodiphenyldichloroethylene (p,p’-DDE) and γ-hexachlorocyclohexane (γ-HCH) being at the highest concentrations. Of the organochlorines measured in clostrum samples from women in preterm labor, median levels of DDTs (470 ng/g) and HCHs (99 ng/g) were higher than for the same compounds from women in normal labor (median of DDTs = 268 ng/g and median of HCHs = 96 ng/g). Normal labor had higher median concentrations of HCB (19.5 ng/g) versus preterm labor (14 ng/g). Statistical data show high Spearman correlation coefficients between various OCPs. We found a good correlation between α-, γ-, β- and δ- HCH isomers (p < 0.001) for both normal and preterm labor. The most abundant target compound was p,p’-DDE (median value 96 ng/g, and 137 ng/g for mother with normal and preterm labor, respectively) in all colostrum samples. The estimated daily intakes of HCHs by infants exceeded corresponding Health Canada guidelines. 相似文献
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9.
A chelating fibrous polymer with metal complexing ability was prepared by partial conversion of the nitrile groups of melana (an acrylonitrile‐based synthetic fiber) into amidoxime groups ? C(NH2) = NOH using a solution of 3% hydroxylamine in methanol by refluxing at 80°C. The molar ratio of NH2OH/CN and the reaction time were adjusted to values of 0.9 and 2 h, respectively. The amidoximated polyacrylonitrile fiber with a 2.89 meq/g ion‐exchange capacity functions as an efficient chelating adsorbent for palladium ions. The pH dependence, the contact time, and the temperature of palladium ion retention from a model solution on amidoximated acrylic fiber were studied. The fibrous chelating adsorbent exhibited high affinity for palladium ions in acidic solution (pH = 2–6) at high temperature (50–60°C). The values of parameters qm and KL (from the Langmuir equation) determined at different temperatures of adsorption and the thermodynamic quantities ΔG, ΔH, and ΔS were calculated. The adsorbed palladium ions can be quantitatively desorbed by elution with a 0.3% hydrochloric solution of thiourea. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 92: 3730–3735, 2004 相似文献
10.
New β-cyclodextrin-based side-chain azo amphiphilic polyurethanes were prepared. Aggregation behaviour was studied by employing steady-state fluorescence and UV–Vis spectroscopy techniques and, determination of the hydrodynamic diameter of micellar aggregates in N,N-dimethyl formamide and N,N-dimethyl formamide/ethanol mixture solutions was done. An apparent polarity evidenced by increasing I 1/I 3 ratio with the increasing concentration of polyurethanes except the polyurethanes with stronger intra- and intermolecular hydrogen bonding of hard segments was obtained. Pyrene resides predominantly in the interfacial region in micellar aggregates that is sensitive to polarity changes due to solvent penetration. Apparent critical micelle concentration due to the presence of β-cyclodextrin was determined by steady-state fluorescence and UV–Vis spectroscopy techniques which ranged between 10?2 and 10?1 g/L. Binding constants from both spectroscopy techniques were determined. The values of hydrodynamic diameter for the amphiphilic poly(ether urethane)s show that their aggregation behaviour is different in function of chemical composition, type and content of hard segment and hydrophobe/hydrophile ratio. 相似文献