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排序方式: 共有530条查询结果,搜索用时 15 毫秒
1.
Emilia Piosik Marta Ziegler-Borowska Dorota Cheminiak-Dudkiewicz Tomasz Martyski 《International journal of molecular sciences》2021,22(5)
An adsorption process of magnetite nanoparticles functionalized with aminated chitosan (Fe3O4-AChit) showing application potential in nanomedicine into cell membrane models was studied. The cell membrane models were formed using a Langmuir technique from three selected phospholipids with different polar head-groups as well as length and carbon saturation of alkyl chains. The research presented in this work reveals the existence of membrane model composition-dependent regulation of phospholipid-nanoparticle interactions. The influence of the positively charged Fe3O4-AChit nanoparticles on a Langmuir film stability, phase state, and textures is much greater in the case of these formed by negatively charged 1,2-dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) (DPPG) than those created by zwitterionic 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) and 2-oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine (POPC). The adsorption kinetics recorded during penetration experiments show that this effect is caused by the strongest adsorption of the investigated nanoparticles into the DPPG monolayer driven very likely by the electrostatic attraction. The differences in the adsorption strength of the Fe3O4-AChit nanoparticles into the Langmuir films formed by the phosphatidylcholines were also observed. The nanoparticles adsorbed more easily into more loosely packed POPC monolayer. 相似文献
2.
Dorota Butkiewicz Magorzata Krzeniak Agnieszka Gdowicz-Kosok Monika Giglok Magorzata Marszaek-Zeczak Rafa Suwiski 《International journal of molecular sciences》2021,22(11)
For non-small cell lung cancer (NSCLC), radiotherapy (RT) and platinum-based chemotherapy (CHT) are among the main treatment options. On the other hand, radioresistance and cytotoxic drug resistance are common causes of failure. The epidermal growth factor receptor (EGFR) plays an important role in radioresponse and therapy resistance. We hypothesized that single nucleotide polymorphisms (SNPs) in the EGFR gene might affect individual sensitivity to these treatments, and thus, therapy outcome and prognosis. The association between functional EGFR SNPs and overall (OS), locoregional recurrence-free (LFRS), and metastasis-free (MFS) survival was examined in 436 patients with unresectable NSCLC receiving RT and platinum-based CHTRT. In a multivariate analysis, the rs712830 CC homozygotes showed reduced OS in the whole group (p = 0.039) and in the curative treatment subset (p = 0.047). The rs712829 TT genotype was strongly associated with decreased LRFS (p = 0.006), and the T-C haplotype was a risk factor for locoregional recurrence in our patients (p = 0.003). The rs2227983 GG alone and in combination with rs712829 T was an indicator of unfavorable LRFS (p = 0.028 and 0.002, respectively). Moreover, significant independent effects of these SNPs on OS, LRFS, and MFS were observed. Our results demonstrate that inherited EGFR gene variants may predict clinical outcomes in NSCLC treated with DNA damage-inducing therapy. 相似文献
3.
Dorota Johansson Björn Bergenståhl 《Journal of the American Oil Chemists' Society》1992,69(8):728-733
The influence of water on the interactions between fat and sugar crystals dispersed in triglyceride (vegetable) oils was qualitatively
estimated from sedimentation and rheological experiments. The experiments were performed both with and without food emulsifiers
(monoglycerides and lecithins) present in the oil. The effects of minor natural oil components (nontriglycerides) on the interactions
and on emulsifier adsorption to the crystals were examined by comparing a commercial refined oil and a chromatographically
purified oil. The results show that water generally increases the adhesion between fat and sugar crystals in oils and also
increases the surface activity of the oil-soluble food emulsifiers. Minor oil components give a small increase in the adhesion
between fat and sugar crystals in oils, but do not influence the adsorption of food emulsifiers in any systematic way. 相似文献
4.
Karol MalechaAuthor Vitae Dorota G. PijanowskaAuthor VitaeLeszek J. GolonkaAuthor Vitae Piotr KurekAuthor Vitae 《Sensors and actuators. B, Chemical》2011,155(2):923-929
This article presents design, fabrication and testing of a miniature ceramic-based biosensor which is destined for continuous glucose monitoring. It is fabricated using well known LTCC (low temperature co-fired ceramics) technology. The biosensor consists of a microreaction chamber, three thick-film electrodes and a microdialysis tube. The detection process is based on oxidation of glucose by molecular oxygen in the presence of enzyme - glucose oxidase, GOx. One of the reaction products is a hydrogen peroxide which is detected amperometrically during its oxidation at a working electrode. Computational fluid dynamics (CFD) analysis was used for optimization of the biosensor geometry and considerations of the influence of operating conditions (flow rate) on mass transfer (diffusion) of the glucose within the microreaction chamber. Tests of the developed LTCC-based biosensor indicate its linear response to glucose concentration up to 9 mM with a relatively high sensitivity of about 147 nA/mM. Moreover, the properties of the presented ceramic biosensor are compared with properties of a similar device made in silicon/glass and in Perspex®. 相似文献
5.
6.
Dorota Leszczyńska-Jasion Paweł Łupkowski 《Journal of Logic, Language and Information》2016,25(1):51-76
Our aim is to model the behaviour of a cognitive agent trying to solve a complex problem by dividing it into sub-problems, but failing to solve some of these sub-problems. We use the powerful framework of erotetic search scenarios (ESS) combined with Kleene’s strong three-valued logic. ESS, defined on the grounds of Inferential Erotetic Logic, has appeared to be a useful logical tool for modelling cognitive goal-directed processes. Using the logical tools of ESS and the three-valued logic, we will show how an agent could solve the initial problem despite the fact that the sub-problems remain unsolved. Thus our model not only indicates missing information but also specifies the contexts in which the problem-solving process may end in success despite the lack of information. We will also show that this model of problem solving may find use in an analysis of natural language dialogues. 相似文献
7.
The global vaccination programme against smallpox led to its successful eradication and averted millions of deaths. Monkeypox virus (MPXV) is a close relative of the Variola (smallpox) virus. Due to antigenic similarity, smallpox vaccines cross-protect against MPXV. However, over 70% of people living today were never vaccinated against smallpox. Symptoms of monkeypox (MPX) include fever, head- and muscle ache, lymphadenopathy and a characteristic rash that develops into papules, vesicles and pustules which eventually scab over and heal. MPX is less often fatal (case fatality rates range from <1% to up to 11%) than smallpox (up to 30%). MPXV is endemic in sub-Saharan Africa, infecting wild animals and causing zoonotic outbreaks. Exotic animal trade and international travel, combined with the increasing susceptibility of the human population due to halted vaccination, facilitated the spread of MPXV to new areas. The ongoing outbreak, with >10,000 cases in >50 countries between May and July 2022, shows that MPXV can significantly spread between people and may thus become a serious threat to public health with global consequences. Here, we summarize the current knowledge about this re-emerging virus, discuss available strategies to limit its spread and pathogenicity and evaluate its risk to the human population. 相似文献
8.
Artur Bekaa Wodzimierz Potek Dorota Siwicka-Gieroba Joanna Soek-Pastuszka Romuald Bohatyrewicz Jowita Biernawska Katarzyna Kotfis Magdalena Bielacz Andrzej Jaroszyski Wojciech Dabrowski 《International journal of molecular sciences》2022,23(13)
Brain injury, especially traumatic brain injury (TBI), may induce severe dysfunction of extracerebral organs. Cardiac dysfunction associated with TBI is common and well known as the brain–heart crosstalk, which broadly refers to different cardiac disorders such as cardiac arrhythmias, ischemia, hemodynamic insufficiency, and sudden cardiac death, which corresponds to acute disorders of brain function. TBI-related cardiac dysfunction can both worsen the brain damage and increase the risk of death. TBI-related cardiac disorders have been mainly treated symptomatically. However, the analysis of pathomechanisms of TBI-related cardiac dysfunction has highlighted an important role of melatonin in the prevention and treatment of such disorders. Melatonin is a neurohormone released by the pineal gland. It plays a crucial role in the coordination of the circadian rhythm. Additionally, melatonin possesses strong anti-inflammatory, antioxidative, and antiapoptotic properties and can modulate sympathetic and parasympathetic activities. Melatonin has a protective effect not only on the brain, by attenuating its injury, but on extracranial organs, including the heart. The aim of this study was to analyze the molecular activity of melatonin in terms of TBI-related cardiac disorders. Our article describes the benefits resulting from using melatonin as an adjuvant in protection and treatment of brain injury-induced cardiac dysfunction. 相似文献
9.
Fatemeh Noroozi Tomasz Sapiński Dorota Kamińska Gholamreza Anbarjafari 《International Journal of Speech Technology》2017,20(2):239-246
This paper proposes a new vocal-based emotion recognition method using random forests, where pairs of the features on the whole speech signal, namely, pitch, intensity, the first four formants, the first four formants bandwidths, mean autocorrelation, mean noise-to-harmonics ratio and standard deviation, are used in order to recognize the emotional state of a speaker. The proposed technique adopts random forests to represent the speech signals, along with the decision-trees approach, in order to classify them into different categories. The emotions are broadly categorised into the six groups, which are happiness, fear, sadness, neutral, surprise, and disgust. The Surrey Audio-Visual Expressed Emotion database is used. According to the experimental results using leave-one-out cross-validation, by means of combining the most significant prosodic features, the proposed method has an average recognition rate of \(66.28\%\), and at the highest level, the recognition rate of \(78\%\) has been obtained, which belongs to the happiness voice signals. The proposed method has \(13.78\%\) higher average recognition rate and \(28.1\%\) higher best recognition rate compared to the linear discriminant analysis as well as \(6.58\%\) higher average recognition rate than the deep neural networks results, both of which have been implemented on the same database. 相似文献
10.
Dawid Stawski Priyanka Sahariah Martha Hjálmarsdóttir Dorota Wojciechowska Michał Puchalski Már Másson 《纺织学会志》2017,108(6):1041-1049
The paper presents a method of depositing N,N,N-trimethyl chitosan (TMC) layers onto polypropylene and polylactide nonwovens. A two-step modification procedure is applied: first, grafting the nonwovens with acrylic acid and next layer-by-layer deposition. Turbidimetric measurements confirm the creation of polycomplexes between grafted poly(acrylic acid) and deposited TMC. The created material structure is evaluated using gravimetric analysis, reflectance Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive spectroscopy measurements and pH-metric titration. The modified material exhibits good antibacterial properties against Gram-positive bacteria Staphylococcus aureus. 相似文献