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Cover Picture: Discovery of MK‐8970: An Acetal Carbonate Prodrug of Raltegravir with Enhanced Colonic Absorption (ChemMedChem 2/2015) 下载免费PDF全文
Dr. Abbas M. Walji Dr. Rosa I. Sanchez Dr. Sophie‐Dorothee Clas Dr. Rebecca Nofsinger Dr. Manuel de Lera Ruiz Dr. Jing Li Dr. Amrithraj Bennet Christopher John Dr. David Jonathan Bennett Dr. John M. Sanders Christina N. Di Marco Somang Hope Kim Dr. Jaume Balsells Scott S. Ceglia Dr. Qun Dang Kimberly Manser Becky Nissley Dr. John S. Wai Dr. Michael Hafey Junying Wang Gene Chessen Dr. Allen Templeton Dr. John Higgins Dr. Ronald Smith Dr. Yunhui Wu Dr. Jay Grobler Dr. Paul J. Coleman 《ChemMedChem》2015,10(2):213-213
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Dorothee Reinmüller 《Refocus》2002,3(3):28
The large number of households that need catering for in market based approaches to rural energy supply in developing countries makes different demands on all involved players: an extensive infrastructure for reaching the rural customer needs to be established, extensive investments have to be realised, financial sustainability must be assured, and the business must even show profit. Thus, for successful market and infrastructure development it is a major necessity to understand the mechanisms involved. Dorothee Reinmüller, International Solar Energy Society (ISES), Germany and Rana Adib, Fraunhofer Institute for Solar Energy Systems ISE, Germany describe a new guide to assist governments, business, and financing organisations in providing energy to rural areas using renewables. 相似文献
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Fofana I. Wasserberg V. Borsi H. Gockenbach E. Farzaneh M. 《Dielectrics and Electrical Insulation, IEEE Transactions on》2006,13(3):593-600
In this paper, premature damage to some static inverter loading resistor modules is analyzed. Furthermore, investigations were carried out to determine the origins and causes of this serious damage occurring on the resistor modules in service. Investigations were preformed on the insulating liquid samples as well as new resistor modules. From the results obtained, it seems that the origin of the damage is from a long-standing, free-burning arc between two resistor windings, following mechanical breakdown. 相似文献
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Dorothee Arens Werner Grosch 《Zeitschrift für Lebensmitteluntersuchung und -Forschung A》1974,156(5):292-299
Summary Ground ripe and freeze-dried half-ripe peas were aerobically incubated with linoleic acid (pH 6.5, 15°C, 20 min). The following reaction products were isolated and identified: oxodiene-, epoxyhydroxy-, mono, di-, and trihydroxy fatty acids. These compounds were also produced when linoleic acid was incubated with a purified lipoxygenase isoenzyme (isolated from peas). By decreasing the lipoxygenase concentration, relative to the substrate, the number of reaction products also decreases: di- and tri-hydroxy acids no longer appear. Fewer mono- and epoxyhydroxy acids compared with hydroperoxides are formed at decreasing enzyme concentrations. However in all the experiments these two compounds were the main products of lipoxygenase catalysis. The hydroperoxides are not the precursors of the monohydroxy and epoxy acids.
Dedicated to Professor Dr. S. W. Souci on his 70th birthday.
We are grateful to the Deutsche Forschungsgemeinschaft Bonn-Bad Godesberg for supporting this work. 相似文献
Nicht-flüchtige Reaktionsprodukte aus Linolsäure. Vergleich einer Erbsenmehlsuspension mit einer gereinigten Erbsen-Lipoxygenase
Zusammenfassung Gemahlene reife und gefriergetrocknete halbreife Erbsen wurden aerob mit Linolsäure incubiert (pH 6,5; 15°C; 20 min). Als Reaktionsprodukte wurden isoliert und identifiziert: Ketodien-, Epoxyhydroxy-, Mono-, Di- und Trihydroxyfettsäuren. Diese Verbindungen entstehen auch, wenn Linolsäure mit einem gereinigten Lipoxygenase-Isoenzym (isoliert aus Erbsen) incubiert wird. Bei relativ zum Substrat abnehmender Lipoxygenasekonzentration sinkt die Zahl der Reaktionsprodukte: Di- und Trihydroxysäuren treten nicht mehr auf. Relativ zu den Hydroperoxyden werden bei sinkender Enzymkonzentration weniger Mono- und Epoxyhydroxysäuren gebildet. In allen Versuchen waren diese beiden Verbindungen aber die Hauptprodukte der Lipoxygenase-Katalyse. Die Hydroperoxyde sind nicht die Vorläufer der Monohydroxy- und Expoxysiiuren.
Dedicated to Professor Dr. S. W. Souci on his 70th birthday.
We are grateful to the Deutsche Forschungsgemeinschaft Bonn-Bad Godesberg for supporting this work. 相似文献
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Singlewalled carbon nanotube/polyvinylalcohol composite nanofibers were electro-spun onto a silicon surface pre-patterned with trenches. These nanofibers were prepared with different loadings of SWCNTs and had radii between 20 and 40 nm. Individual fiber sections were pinned across the trenches and laterally loaded by an AFM tip to yield mechanical response curves. A simple model was exploited to extract the tensile mechanical properties from the lateral force-displacement data. Depending on the fiber composition, the tensile modulus was found to be between 3 and 85 GPa. In addition we have prepared fibers with tensile strength of up to 2.6 GPa. Such optimised fibers break at strains of ∼4% and exhibit toughness of up to 27 MJ/m3. 相似文献
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Cynthia L. Miltenburg Todd F. Duffield Dorothee Bienzle Elizabeth L. Scholtz Stephen J. LeBlanc 《Journal of dairy science》2018,101(10):9505-9509
Low total blood calcium concentration after calving has been demonstrated to be a risk factor for reduced neutrophil function. The objective of this study was to evaluate whether administration of an injectable calcium supplement product soon after calving increased neutrophil oxidative burst or phagocytosis capacity. Cows (n = 27) from 4 farms were blocked by parity and randomly assigned to receive either calcium gluconate (35% wt/vol) in combination with calcium glucoheptonate (10% wt/vol; Theracalcium, Vétoquinol Canada Inc., Lavaltrie, Quebec, Canada) or a placebo within 12 h after calving and again 24 h later. Each dose of 120 mL was injected subcutaneously over 2 sites. Total serum calcium concentration, neutrophil oxidative burst, and neutrophil phagocytosis capacity were measured from coccygeal blood samples before (time 0) and 72 h after first treatment. There was no difference between treatment groups in lactation number, total calcium concentration, oxidative burst, or phagocytosis at time of enrollment. There was no effect of treatment on oxidative burst or phagocytosis by neutrophils. This preliminary study does not support an effect of supplemental calcium to improve neutrophil oxidative burst or phagocytosis capacity of low-parity parturient cows. 相似文献
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Analysis of Transcriptional Regulation of the Human miR-17-92 Cluster; Evidence for Involvement of Pim-1 总被引:1,自引:0,他引:1