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1.
A real-time distributed database system (RTDDBS) must maintain the consistency constraints of objects and must also guarantee the time constraints imposed by each request arriving at the system. Such a time constraint of a request is usually defined as a deadline period, which means that the request must be serviced on or before its time constraint. Servicing these requests may incur I/O costs, control-message transferring costs or data-message transferring costs. As a result, in our work, we first present a mathematical model that considers all these costs. Using this cost model, our objective is to service all the requests on or before their respective deadline periods and minimize the total servicing cost. To this end, from theoretical standpoint, we design a dynamic object replication algorithm, referred to as Real-time distributed dynamic Window Mechanism (RDDWM), that adapts to the random patterns of read-write requests. Using competitive analysis, from practical perspective, we study the performance of RDDWM algorithm under two different extreme conditions, i.e., when the deadline period of each request is sufficiently long and when the deadline period of each request is very short. Several illustrative examples are provided for the ease of understanding. Recommended by: Ashfaq Khokhar  相似文献   
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Context: Skin cancer represents the most growing types of cancer in human and ultraviolet radiation can be cited as one of the prime factor for its occurrence. Current therapy of skin cancer suffers from numerous side effects; for effective therapy, topical application of formulation of paclitaxel (PTX) can be considered as a novel approach.

Objective: The present study is an attempt to prepare formulation of solid lipid nanoparticles (SLN) of PTX for the effective treatment of various form of skin carcinoma.

Methods: The SLN were prepared by high-speed homogenization and ultrasonication method. The prepared SLN were characterized. The optimized PTX SLN were loaded in carbopol gel. The prepared gels were evaluated for its gelling properties and finally studied for in vivo anti-cancer efficacy and histopathological study.

Results: The particle size distribution was found to be in the range of 78.82–587.8?nm. The product yield (%) was found between 60% and 66% and showed a highest entrapment efficiency of 68.3%. The in vitro release of the drug from SLN dispersion was found to be biphasic with the initial burst effect, followed by slow release. SLN-loaded gel were subjected to permeability study and the results show steady-state flux (Jss), permeability coefficient (Kp), and enhancement ratio were significantly increased in SLN-loaded gel formulation as compared with PTX-loaded gel. The histopathological study clearly reveals the efficacy of the SLN-F3 3G in the treatment of skin cancer.

Conclusion: The experimental formulations show controlled release of PTX and thus expected to show reduce dose-related side effects.  相似文献   
4.
Fault-tolerant scheduling is an imperative step for large-scale computational Grid systems, as often geographically distributed nodes co-operate to execute a task. By and large, primary-backup approach is a common methodology used for fault tolerance wherein each task has a primary and a backup on two different processors. In this paper, we address the problem of how to schedule DAGs in Grids with communication delays so that service failures can be avoided in the presence of processors faults. The challenge is, that as tasks in a DAG have dependence on each other, a task must be scheduled to make sure that it will succeed when any of its predecessors fails due to a processor failure. We first propose a communication model and determine when communications between a backup and backups of its successors are necessary. Then we determine when a backup can start and its eligible processors so as to guarantee that every DAG can complete upon any processor failure. We develop two algorithms to schedule backups, which minimize response time and replication cost, respectively. We also develop a suboptimal algorithm which targets minimizing replication cost while not affecting response time. We conduct extensive simulation experiments to quantify the performance of the proposed algorithms.  相似文献   
5.
The problem of minimizing the access time of a requested multimedia (MM) document on a network based environment is addressed. A generalized version of this problem is formulated and retrieval strategies that minimize the access time of the user-requested MM document from a pool of MM servers are proposed. To this end, we design single-installment and multi-installment MM document retrieval strategies, through which the minimization of access time can be carried out. The main idea is to utilize more than one MM server in downloading the requested document. Each server assumes the responsibility of uploading a predetermined portion of the entire document in a particular order. Single- and multi-installment strategies differ in the number of disjoint document pieces each server sends to the client. We first introduce a directed flow graph (DFG) model to represent the retrieval process and generate a set of recursive equations using this DFG. Then, we derive closed-form solutions for the portions of the MM document downloaded from the various servers and the corresponding access time. We present rigorous analysis for these two strategies and show their performance under MPEG-I and MPEG-II video streams playback rates. Their behavior under different network bandwidths is also examined, revealing in-depth information about their expected performance. We also show that in the case of a multi-installment strategy, the access time can be completely controlled by fine tuning the number of installments. Since the number of installments is software tunable, the adaptive nature of the strategies to different channel bandwidths is also demonstrated. Important trade-off studies with respect to the number of servers involved in the retrieval process and the number of installments are presented. In the case of a heterogeneous network employing a single-installment strategy, we prove that the access time is independent of the server sequence used. Illustrative examples are provided for ease of understanding.  相似文献   
6.
Induction motors, both three and single phase, are used extensively for adjustable-speed drives' applications. These machines are structurally very robust and are a primary source of motive power and speed control where DC machines cannot be used. For closed-loop control of these machines, sensorless speed estimation is usually preferred. Among the current estimation techniques available for speed-sensorless induction motor drives, speed measurement based on rotor-slot-related harmonic detection in machine line current happens to be a prominent one. While these harmonics can be strong in certain kinds of machines, some other machines may exhibit very weak rotor slot harmonics that can be obscured by noise. Skewing, slot shapes and types, structural unbalances, etc., also have a prominent effect on the detectability of these harmonics. This paper attempts to investigate this problem based on the interaction of pole pairs, number of rotor bars, and stator winding. Although the analysis and experimental results have been mainly provided for three-phase squirrel-cage induction motors, single-phase and slip-ring induction motors have also been addressed. Further, it has been shown that eccentricity-related fault detection could also be easily accommodated with this kind of speed detection technique at no or negligible extra cost when certain motors are selected.  相似文献   
7.
Bunsen reaction is an important step of sulfur–iodine cycle for hydrogen production from thermochemical splitting of water. Polyiodide species generated during the separation process need to be identified for complete understanding of the mechanism involved. Speciation of these polyiodide species formed during Bunsen reaction can lead to better understanding of kinetics of the process. HIx species formed have been analyzed using UV–visible and Raman spectroscopic techniques. Peak corresponding to HI3 species have been ascertained and their conversion to higher HI5, HI7 …… species has been observed.  相似文献   
8.
Co-Zn ferrite nano-powder was synthesized using the Microwave- Hydrothermal (M-H) method. The powder was characterized using X-ray diffraction (XRD), Transmission Electron Microscopy (TEM), and Fourier Transform Infrared spectroscopy (FT-IR). The densification of nanoferrites was done using two methods: a) conventional and b) microwave sintering. Electrical and magnetic properties of the sintered samples were measured at room temperature. Electrical properties such as dielectric constant (?'), dissipation factor (D), initial permeability (μi) and quality factor (Q) were measured over a wide frequency range (10 kHz to 1 MHz). The Curie temperature has been determined from the permeability versus temperature plots. It was found that the enhanced electrical and magnetic properties were observed for microwave sintered samples.  相似文献   
9.
The article addresses the problem of reasoning under time constraints with incomplete, vague, and uncertain information. It is based on the idea of Variable Precision Logic (VPL), introduced by Michalski and Winston, which deals with both the problem of reasoning with incomplete information subject to time constraints and the problem of reasoning efficiently with exceptions. It offers mechanisms for handling trade-offs between the precision of inferences and the computational efficiency of deriving them. As an extension of Censored Production Rules (CPRs) that exhibit variable precision in which certainty varies while specificity stays constant, a Hierarchical Censored Production Rules (HCPRs) system of Knowledge Representation proposed by Bharadwaj and Jain exhibits both variable certainty as well as variable specificity. Fuzzy Censored Production Rules (FCPRs) are obtained by augmenting ordinary fuzzy conditional statement: “if X is A then Y is B” (or A(x)B(y) for short) with an exception condition and are written in the form: “if X is A then Y is B unless Z is C” (or A(x) ⇒ B(y) ∥ C(z)). Such rules are employed in situations in which the fuzzy conditional statement “if X is A then Y is B” holds frequently and the exception condition “Z is C” holds rarely. Thus, using a rule of this type we are free to ignore the exception condition, when the resources needed to establish its presence are tight or there simply is no information available as to whether it holds or does not hold. Thus if … then part of the FCPR expresses important information while the unless part acts only as a switch that changes the polarity of “Y is B” to “Y is not B” when the assertion “Z is C” holds. Our aim is to show how an ordinary fuzzy production rule on suitable modifications and augmentation with relevant information becomes a Fuzzy Hierarchical Censored Production Rules (FHCPRs), which in turn enables to resolve many of the problems associated with usual fuzzy production rules system. Examples are given to demonstrate the behavior of the proposed schemes. © 1996 John Wiley & Sons, Inc.  相似文献   
10.
The problem of employing multiple servers to serve a pool of clients on a network based multimedia service is addressed. We have designed and practically implemented a prototype system employing multiple servers to render a long duration movie to the customers. We have employed a multiple server retrieval strategy proposed in the literature [39] to realize this system. In the system, server coordination, client behavior and service facilities are completely controlled by an Agent based approach in which we have used the recent Jini technology. Several issues, ranging from data retrieval from individual server, behavior of the underlying network infrastructure, to client management and resource (client buffers) management, are considered in this implementation. We describe in detail our experiences in this complete design process of every module in the software architecture, its purpose, and working style. Further, the system is shown to be robust amidst unpredictable failures, i.e., in the event of server crashes. The load balancing capability is built-in as a safe guard measure to assure a continuous presentation. We present a comprehensive discussion on the software architecture to realize this working system and present our experiences. A system comprising a series of Pentium III PCs on a fast Ethernet network is built as a test-bed. Through this prototype, a wider scope of research challenges ahead are highlighted as possible extensions. Bharadwaj Veeravalli Member, IEEE & IEEE-CS, received his BSc in Physics, from Madurai-Kamaraj Uiversity, India in 1987, Master's in Electrical Communication Engineering from Indian Institute of Science, Bangalore, India in 1991 and PhD from Department of Aerospace Engineering, Indian Institute of Science, Bangalore, India in 1994. He did his post-doctoral research in the Department of Computer Science, Concordia University, Montreal, Canada, in 1996. He is currently with the Department of Electrical and Computer Engineering, Computer and Information Engineering (CIE) division, at The National University of Singapore, Singapore, as a tenured Associate Professor. His main stream research interests include, Multiprocessor systems, Cluster/Grid computing, Scheduling in parallel and distributed systems, Bioinformatics & Computational Biology, and Multimedia computing. He is one of the earliest researchers in the field of divisible load theory. He has published over 75 papers in high-quality International Journals and Conferences. He had secured several externally funded projects. He has co-authored three research monographs in the areas of Parallel and Distributed Systems, Distributed Databases, and Multimedia systems, in the years 1996, 2003, and 2005, respectively. He had guest edited a special issue on Cluster/Grid Computing for IJCA, USA journal in 2004. He has been recently invited to contribute to Multimedia Encyclopedia, Kluwer Academic Publishers, 2005. He is currently serving the Editorial Board of IEEE Transactions on Computers, IEEE Transactions on SMC-A and International Journal of Computers & Applications, USA, as an Associate Editor. He had served as a program committee member and as a session chair in several International Conferences. Long Chen received the B.E. degree in Electrical Engineering and M.E. degree in Electrical Engineering from the Northwestern Polytechnic University, P. R. China, in 1998 and 2001, respectively, and the M.E. degree in Computer Engineering from the National University of Singapore, Singapore, in 2004. He is currently a Ph.D. candidate at the Department of Electrical and Computer Engineering, the University of Delaware, United States. His research interests include multimedia systems, distributed system, network security, and computer architecture.  相似文献   
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