Cardiovascular effects produced by R-(+)-8-hydroxy-2-(di-n-propylamino) tetralin in the preoptic area of conscious rats

The effect of ancrod-induced defibrinogenation on thrombosis and bleeding time was determined in anesthetized rats. Functional plasma fibrinogen levels were reduced 42, 71, 94 and 93% by ancrod doses of 5, 10, 20 and 30 U/kg, respectively, while a 2.5 U/kg dose was without significant effect. Ancrod inhibited vena cava thrombosis induced by partial stasis of blood flow combined with mild vascular injury. Thrombus weight was decreased 85 and 93% by the 10 and 20 U/kg doses, but was unaffected at lower doses. In contrast, ancrod doses of up to 30 U/kg did not significantly decrease carotid artery thrombi formed in response to oxidative transmural vessel injury. Ancrod caused a dose-dependent increase in bleeding time measured by puncturing small mesenteric arteries with a hypodermic needle. The bleeding time increase was approximately 38% in response to the 2.5 and 5 U/kg doses, and 182% in response to the 10 U/kg dose. These studies demonstrate that ancrod-induced reductions in plasma fibrinogen more effectively inhibit venous compared to arterial thrombosis, although these activities require doses that also increase bleeding time in small arteries.     

Design of a two‐level controller for an active suspension system

The paper focuses on a control design for a vehicle suspension system in which a balance between different performance demands is achieved. The starting point of the control design is a full–car model which contains nonlinear components, i.e. the dynamics of the dampers and springs and nonlinear actuator dynamics. In order to handle the high complexity of the problem this paper proposes the design of a two‐level controller of an active suspension system. The required control force is computed by applying a high‐level controller, which is designed using a linear parameter varying (LPV) method. For the control design the model is augmented with weighting functions specified by the performance demands and the uncertainty assumptions. The actuator generating the necessary control force is modelled as a nonlinear system for which a low‐level force‐tracking controller is designed. To obtain the low‐level controller a backstepping method is proposed. As an alternative solution a feedback linearization method is also presented. The operation of the controller is illustrated through simulation examples. Copyright © 2011 John Wiley and Sons Asia Pte Ltd and Chinese Automatic Control Society     

Nanoparticles in polymer-matrix composites

Regarding the development of nanoparticles for polymer matrix composites the particle/agglomerate size and particle/agglomerate distribution in the composites, respectively, is often crucial. This is exemplarily shown for, e.g. optical applications with measurements of refractive index and transmittance. Classical blending techniques, where nanoparticles are dispersed in polymers or resins, are compared to a combination of a special gas-phase synthesis method with subsequent in-situ deposition of nanoparticles in high-boiling liquids. The particles/agglomerates were characterized regarding particle size and particle size distribution using transmission electron microscopy and dynamic light scattering. Additionally, important material properties like mechanical properties, relevant for application, or like viscosity, relevant for processing, are determined. It is shown, that with in-situ dispersed nanoparticles synthesized in a microwave plasma process composites with finely dispersed particles/agglomerates are attainable.     

Alphonse de Candolle's early scientometrics(1883, 1885) with references to recent trends in the field (1978–1983)

De Candolle analyzed in 1883 and 1885, respectively two important fields of human cultural evolution: the domestication of crop plants and the emergence of modern science. In hisHistoire de science et des savants depuis deux sciecles, principles were established, science indicators outlined, interactions examined and mathematical methods applied to the study of a selected data set related to scientific development. In order to compare national and international scientific communities twenty standard factors were considered and national participation in international scientific societies was analysed for 14 European countries and the United States.De Candolle was the first to analyse mathematically the number, dynamics and national distribution of scientists in their professional organisations, the specialization and professionalization of scientists and characterized the scientific potential of different countries with the number of international science society members per inhabitant per period (1750–1884). The role ofde Candolle as a forerunner of modern scientometrics and the science of science is revealed in a comparison of his work with recent trends. In the first five volumes of the journalScientometrics 51 papers were identified dealing with topics related to those dealt with byde Candolle.     

Kidney hypoplasia and hypertension

The basis of the examination is a clinical material of 14 years (from 1960 to 1973) of the urological clinic of the Medical University "Semmelweis", consisting of 160 patients with renal hypoplasia. In 116 of these cases a nephrectomy was performed. The average postoperative observation time was 7.8 years. By removal of the hypoplastic kidney the hypertension could be successfully influenced in 72% of the cases and in 16% moderately; in 12% of the patients the high blood pressure remained unchanged also after the intervention. On account of the recognition resulting from the examinations that by the hypoplastic kidney alone no increase of the blood pressure is caused, but the developmental anomaly forms a basis for the development of the hypertension, is emphasized that the early removal of this abnormally developed kidney is by all means indicated.     

Hybridization Networks of mRNA and Branched RNA Hybrids

Messenger RNA (mRNA) is emerging as an attractive biopolymer for therapy and vaccination. To become suitable for vaccination, mRNA is usually converted to a biomaterial, using cationic peptides, polymers or lipids. An alternative form of converting mRNA into a material is demonstrated that uses branched oligoribonucleotide hybrids with the ability to hybridize with one or more regions of the mRNA sequence. Two such hybrids with hexamer arms and adamantane tetraol as branching element were prepared by solution-phase synthesis. When a rabies mRNA was treated with the branched hybrids at 1 M NaCl concentration, biomaterials formed that contained both of the nucleic acids. These results show that branched oligoribonucleotides are an alternative to the often toxic reagents commonly used to formulate mRNA for medical applications.     

Periodic material structures tested by the noise spectroscopy method

The authors discuss the testing of periodic materials and structures via noise spectroscopy as an alternative to frequency sweep spectral analyzers, and the presented procedure employs the various advantages offered by a wide spectrum signal a Generally, noise spectroscopy tests are carried out to verify the behaviour of the response of periodic structures, and the related objective consists in recording the properties of microscopic structures in natural and artificial materials. The aim is to propose and verify a high-precision metrological method utilizable for the investigation of structures and materials in the frequency range between 100 MHz and 10 GHz; this paper therefore characterizes the design of a suitable measuring technique based on noise spectroscopy. In this context, the applied equipment is also shown to complement the underlying theoretical analysis.     

ANN–supported control strategy for a solid oxide fuel cell working on demand for a public utility building

The idea of control strategy of SOFC operating to meet demand of a public utility building was presented. The strategy was formulated with the support of Artificial Neural Network. The network was used to predict the demand for electricity. The calculations were carried out on the example of a building of the Institute of Heat Engineering Warsaw University of Technology. The control strategy is influenced by various factors depending on changes in market conditions and operating characteristics of the cell. We can define different objective functions eg: working for own needs, for maximum profit and maximum service life. The article presents a simulation of SOFC operation for demand profile of the IHE building from the selected time period.