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1.
Motrenko Anastasia Simchuk Egor Khairullin Renat Inyakin Andrey Kashirin Daniil Strijov Vadim 《Multimedia Tools and Applications》2022,81(4):4877-4895
Multimedia Tools and Applications - The paper addresses the problem of human activity recognition based on the data from wearable sensors. Human activity recognition depends on a wide context of... 相似文献
2.
Pavel A. Sakharov Egor A. Smolin Dmitry N. Lyabin Sultan C. Agalarov 《International journal of molecular sciences》2021,22(7)
The methylation of adenosine in the N6 position (m6A) is a widely used modification of eukaryotic mRNAs. Its importance for the regulation of mRNA translation was put forward recently, essentially due to the ability of methylated mRNA to be translated in conditions of inhibited cap-dependent translation initiation, e.g., under stress. However, the peculiarities of translation initiation on m6A-modified mRNAs are not fully known. In this study, we used toeprinting and translation in a cell-free system to confirm that m6A-modified mRNAs can be translated in conditions of suppressed cap-dependent translation. We show for the first time that m6A-modified mRNAs display not only decreased elongation, but also a lower efficiency of translation initiation. Additionally, we report relative resistance of m6A-mRNA translation initiation in the absence of ATP and inhibited eIF4A activity. Our novel findings indicate that the scanning of m6A-modified leader sequences is performed by a noncanonical mechanism. 相似文献
3.
Maria S. Parshina Alexander N. Tarasenkov Rinat R. Aysin Nadezhda A. Tebeneva Michail I. Buzin Egor S. Afanasyev Olga A. Serenko Aziz M. Muzafarov 《应用聚合物科学杂志》2021,138(36):50918
In this work, the curing of «ED-20» epoxy resin with partially siloxy-substituted aluminum, iron, and zirconium siloxanes that we obtained previously was studied. The initial content of a metallosiloxane in the compositions was 5–50 wt% with respect to the resin. In all the cases, thermal curing was used to obtain a series of samples in the form of solid homogeneous materials. The fact of the epoxy ring opening in the resin was confirmed by IR spectroscopy. The catalytic properties of the metal atom in a metallosiloxane were found to affect the curing process. The samples demonstrate rather a high resistance to thermooxidative destruction, and in most cases, their glass transition temperatures are lower than those obtained upon standard curing of «ED-20» resin with triethylenetetramine. Partially siloxy-substituted metalloalkoxysiloxanes can be efficient agents for curing and formation of a hybrid material based on epoxy resins. 相似文献
4.
The purpose of this paper is to study the consequences of the composite nature of concrete. A plausible energy balance equation is postulated and the Green-Rivlin invariance principle is applied to it to derive the linear and angular momentum balance laws. General constitutive equations are discussed with the aid of thermodynamic potentials and Coleman's method. The distribution of the applied stresses between mortar and aggregate is also studied in detail, showing for instance that substantial tensile lateral stresses may appear in mortar under uniaxial compressive loading. These results are used to derive a criterion for the onset of inelasticity in concrete. 相似文献
5.
Bulushev Dmitri A. Chuvilin Andrey L. Sobolev Vladimir I. Pirutko Larisa V. Fedoseeva Yuliya V. Lobiak Egor V. Modin Evgenii Okotrub Alexander V. Bulusheva Lyubov G. 《Topics in Catalysis》2019,62(5-6):508-517
Topics in Catalysis - Formic acid and methanol are considered as liquid organic hydrogen carriers and could be produced sustainably from biomass or by CO2 hydrogenation using catalysts. The choice... 相似文献
6.
Elena G. Varlamova Mikhail V. Goltyaev Valentina N. Maltseva Egor A. Turovsky Ruslan M. Sarimov Alexander V. Simakin Sergey V. Gudkov 《International journal of molecular sciences》2021,22(15)
In recent decades, studies on the functional features of Se nanoparticles (SeNP) have gained great popularity due to their high biocompatibility, stability, and pronounced selectivity. A large number of works prove the anticarcinogenic effect of SeNP. In this work, the molecular mechanisms regulating the cytotoxic effects of SeNP, obtained by laser ablation, were studied by the example of four human cancer cell lines: A-172 (glioblastoma), Caco-2, (colorectal adenocarcinoma), DU-145 (prostate carcinoma), MCF-7 (breast adenocarcinoma). It was found that SeNP had different concentration-dependent effects on cancer cells of the four studied human lines. SeNP at concentrations of less than 1 μg/mL had no cytotoxic effect on the studied cancer cells, with the exception of the A-172 cell line, for which 0.5 μg/mL SeNP was the minimum concentration affecting its metabolic activity. It was shown that SeNP concentration-dependently caused cancer cell apoptosis, but not necrosis. In addition, it was found that SeNP enhanced the expression of pro-apoptotic genes in almost all cancer cell lines, with the exception of Caco-2 and activated various pathways of adaptive and pro-apoptotic signaling pathways of UPR. Different effects of SeNP on the expression of ER-resident selenoproteins and selenium-containing glutathione peroxidases and thioredoxin reductases, depending on the cell line, were established. In addition, SeNP triggered Ca2+ signals in all investigated cancer cell lines. Different sensitivity of cancer cell lines to SeNP can determine the induction of the process of apoptosis in them through regulation of the Ca2+ signaling system, mechanisms of ER stress, and activation of various expression patterns of genes encoding pro-apoptotic proteins. 相似文献
7.
Jiayi Yang David Tang Jinping Ao Tushar Ghosh Taylor V. Neumann Dongguang Zhang Egor Piskarev Tingting Yu Vi Khanh Truong Kai Xie Ying‐Chih Lai Yang Li Michael D. Dickey 《Advanced functional materials》2020,30(36)
Soft, capacitive tactile (pressure) sensors are important for applications including human–machine interfaces, soft robots, and electronic skins. Such capacitors consist of two electrodes separated by a soft dielectric. Pressing the capacitor brings the electrodes closer together and thereby increases capacitance. Thus, sensitivity to a given force is maximized by using dielectric materials that are soft and have a high dielectric constant, yet such properties are often in conflict with each other. Here, a liquid metal elastomer foam (LMEF) is introduced that is extremely soft (elastic modulus 7.8 kPa), highly compressible (70% strain), and has a high permittivity. Compressing the LMEF displaces the air in the foam structure, increasing the permittivity over a large range (5.6–11.7). This is called “positive piezopermittivity.” Interestingly, it is discovered that the permittivity of such materials decreases (“negative piezopermittivity”) when compressed to large strain due to the geometric deformation of the liquid metal droplets. This mechanism is theoretically confirmed via electromagnetic theory, and finite element simulation. Using these materials, a soft tactile sensor with high sensitivity, high initial capacitance, and large capacitance change is demonstrated. In addition, a tactile sensor powered wirelessly (from 3 m away) with high power conversion efficiency (84%) is demonstrated. 相似文献
8.
Two large bolted steel moment-resisting connections were studied by experiments. These connections were single-sided beam-to-column assemblies that are representative of exterior beam-to-column connections, and they were composed of W36×150 Grade 50 beams and W14×283 Grade 50 columns. T-stubs were cut from W40×264 sections of Grade 50 steel. The T-stub stems were welded to the beams and prestressed by bolts to the beam flanges in the shop. Final beam-to-column assembly required no additional welding: the T-stub flanges were bolted to the column and the column shear tab was bolted to the beam web. The specimens had two symmetrically located T-stubs with different stem geometry: Specimen 1 had rectangular-shaped stems, whereas Specimen 2 had U-shaped stems. During the cyclic testing the beam deformation was minimal controlled by active participation of the T-stub flanges: a separation between T-stub flanges and the column flanges was observed. This separation was caused by bending plastic deformation in the T-stub flanges and plastic deformation in the high-strength bolts. This phenomenon allowed energy dissipation and prevented severe buckling of the beam flanges and beam web. 相似文献
9.
Egor P. Popov 《Engineering Structures》1983,5(1):3-9
Recent research developments on eccentrically braced steel frames for seismic design are reviewed. The emphasis is placed on the design of links, which are short sections of beams between columns and braces, and similar elements at eccentric joints. The review includes some highlights of the latest experiments with one-third scale models employing different eccentric bracing schemes, an updated classification of links, and special design requirements for different types of links. Some results are given on recent cyclic tests of full-size links. 相似文献
10.
Olga A. Averina Oleg A. Permyakov Olga O. Grigorieva Alexey S. Starshin Alexander M. Mazur Egor B. Prokhortchouk Olga A. Dontsova Petr V. Sergiev 《International journal of molecular sciences》2021,22(19)
Genome editing is an indispensable tool for functional genomics. The caveat of the genome-editing pipeline is a prevalence of error-prone non-homologous end joining over homologous recombination, while only the latter is suitable to introduce particularly desired genetic variants. To overcome this problem, a toolbox of genome engineering was appended by a variety of improved instruments. In this work, we compared the efficiency of a number of recently suggested improved systems for genome editing applied to the same genome regions on a murine zygote model via microinjection. As a result, we observed that homologous recombination utilizing an ssDNA template following sgRNA directed Cas9 cleavage is still the method of choice for the creation of animals with precise genome alterations. 相似文献